Mice lacking alpha-tocopherol transfer protein gene have severe alpha-tocopherol deficiency in multiple regions of the central nervous system

Ataxia with vitamin E deficiency is caused by mutations in a-tocopherol transfer protein (a-TTP) gene and it can be experimentally generated in mice by a-TTP gene inactivation (a-TTP-KO). This study compared a-tocopherol (a-T) concentrations of five brain regions and of four peripheral organs from 5 months old, male and female, wild-type (WT) and a-TTP-KO mice. All brain regions of female WT mice contained significantly higher a-T than those from WT males. a-T concentration in the cerebellum was significantly lower than that in other brain regions of WT mice. These sex and regional differences in brain a-T concentrations do not appear to be determined by a-TTP expression which was undetectable in all brain regions. All the brain regions of a-TTP-KO mice were severely depleted in a-T. The concentration of another endogenous antioxidant, total glutathione, was unaffected by gender but was decreased slightly but significantly in most brain regions of a-TTP-KO mice. The results show that both gender and the hepatic a-TTP, but not brain a-TTP gene expression are important in determining a-T concentrations within the brain. Interestingly, functional abnormality (ataxia) develops only very late in a-TTP-KO mice in spite of the severe a-tocopherol deficiency in the brain starting at an early age.

Mechanically tunable multiband compact quadrifilar helix antenna with dual mode operation

We show that by introducing a gap at the center of the helical sections (where the current is minimum) of a lambda/2 quadrifilar helix antenna (QHA) and varying the axial length and radial gap between the overlapping volutes, the antenna gives a 28% impedance bandwidth which is nine times the bandwidth of a conventional QHA. A 16% bandwidth with a front to back ratio of >= 14 dB is achievable with 5-14% reduction in the size of the QHA. The structure can yield a monopole radiation pattern suitable for terrestrial applications or a hemispherical pattern suitable for satellite use. The simulation results are validated by measurements at L-band.

Dual-mode compact structure comprising of side-fed bifilar and quadrifilar helix antenna

A side-fed bifilar helix antenna can be integrated with a quadrifilar helix antenna in a piggy back configuration in order to achieve a dual-mode radiating structure. The overall length of the structure is 0.44 lambda at the resonant frequency (1.54 GHz) of the space mode antenna and 0.39 lambda at the resonant frequency (1.34 GHz) of the terrestrial mode antenna. The computed results are validated by experimental data.

Effect of helix turn angle on the performance of a half wavelength quadrifilar antenna

The impedance and radiation pattern parameters of a lambda/2 quadrifilar helix antenna (QHA) with turn angles in the range 0 degrees to 235 degrees are analyzed. It is shown that by selecting the helix turn angle to satisfy the minimum bandwidth and beamwidth requirements, an improved electrical performance and a reduction in the physical size of the antenna is obtained. This is demonstrated by comparing the performance of a conventional half turn QHA with structures having a smaller pitch length. The computed results are validated by experimental data at L-band.

Side-fed bifilar helix antenna

A side-fed bifilar is shown to generate a similar radiation pattern as a dipole antenna, but the structure has a significantly reduced axial length. Simulated and measured results show that the helix turn angle can be used to control the ratio of the orthogonal linear field components and the input impedance.

Compact quadrifilar helix antenna

Introduction: The quadrifilar helix antenna (QHA) is used widely for terrestrial [1] and space communication systems [2], where it is necessary to generate a circularly polarised cardioid-shaped radiation pattern with a high front-to-back ratio and low cross-polarisation. The radiating structure comprises four helical conductors which are excited in phase quadrature at the feed point, which is usually located at the centre of the top radials. The physical size of the quadrifilar antenna can be reduced by dielectric loading [3] or by meandering the printed linear elements [4]. However, in the former arrangement dielectric absorption reduces the radiation efficiency of the antenna, and the latter technique is not suitable for constructing free standing wire structures, which are normally used for spacecraft payloads in the VHF and UHF bands [2]. This Letter shows that a significant reduction in the axial length of a 1/2 turn half-wavelength QHA can be achieved by modifying the geometry of the helices in the region around the midpoint where a current null exists. Simulated and experimental results at L band are used to show that a size reduction of up to 15% is possible without significantly degrading the pattern shape and the bandwidth.

Bandwidth limitation of two-port fed and self-phased quadrifilar helix antennas

The bandwidth of a resonant quadrifilar helix antenna (QHA) is shown to be strongly dependent on the design of the feed network. In this paper, we compare the impedance and radiation-pattern performance of two QHAs driven by different feed arrangements. A qualitative explanation for the difference in the behaviour of the antenna is given by observing the amplitude and phase distribution of the current in the helices. (c) 2005 Wiley Periodicals, Inc.