Anàlisi agronòmica i ambiental dels cultius cerealístics de secà de la plana de Lleida

Al llarg d’aquest estudi es descriuen les tècniques de cultiu i alguns elements de les explotacions agràries de les diferents ZEPA d’hàbitat estèpic. El document inclou a l’apartat 4, les recomanacions tecnològiques per a la millora de la gestió agronòmica de cadascun dels pais estudiats que son vàlides per als secans cerealistes de la plana de Lleida, així com de moltes zones cerealistes de la Vall de l’Ebre i d’altres indrets amb condicions mediterrànies. En general s’observa que aquestes zones cerealistes presenten característiques de clima i sòl que condicionen la productivitat agrícola de manera important. El principal factor limitant és l’aigua disponible per als cultius, que ve condicionada per les pluges irregulars intera-anuals i també intra-anuals, i per l’eficiència en l’absorció i ús per part dels conreus. El sòl al seu torn, condiciona generalment la capacitat d’emmagatzematge d’aigua i en alguns casos introdueix algunes limitacions com la salinitat o alcalinitat. A aquests condicionants cal afegir la dimensió de les explotacions, l’estructura de la propietat i altres característiques socials, culturals i econòmiques que limiten la renda agrària. Aquesta marginalitat econòmica i social es veu resolta en algunes ocasions pel complement de la renda mitjançant l’activitat agrícola en regadiu i d’activitats ramaderes intensives. Les àrees d’estudi estan dotades d’una alta tecnificació agrícola, fins i tot amb excés de mecanització, i on les pràctiques de cultiu estan arrelades de forma tradicional. Tanmateix, encara hi ha un espai molt important per a la millora i optimització tecnològica. Aquesta és essencial i necessària pel que fa a la millora econòmica de la renda reduint els costos de cultiu i també per a una recuperació mediambiental del sistema agrícola, més enllà de l’interès per la protecció de les aus i d’altres elements de la biodiversitat o el paisatge. Actualment, algu- nes de les pràctiques agrícoles habituals afavoreixen l’erosió del sòl i la reducció de la matèria orgànica del mateix. El manteniment del sòl i de la seva qualitat són elements importants en la sostenibilitat d’aquestes àrees i en la productivitat a diferents nivells. Així mateix, el control de la fertilització és necessari per evitar problemes de contaminació per nitrats del sòl i de l’aigua, els quals es comencen ja a detectar en algunes de les ZEPA. Davant de la necessitat i exigència actual de promoure sistemes productius sostenibles ambientalment i agronòmica, el present estudi aporta algunes observacions i planteja recomanacions i propostes per tal d’assolir aquest objectiu.

Projecte de gestió conjunta de dos ramats de boví de carn a Borredà (Berguedà)

Disseny de dues explotacions de boví de carn, que actuaran com a una única explotació a nivell sanitari i a nivell de maneig. Es farà un estudi de viabilitat de diferents alternatives a nivell de maneig, tant del bestiar com dels camps, de comercialització, de races, d’alimentació i d’estructures productives. Així mateix i com a complement a l’activitat prevista, es projecta la construcció d’un cobert amb cornadís per alimentar les vaques. Les dues explotacions estan registrades a les finques “El Coll” i “Subirà”, confrontants dins el terme municipal de Borredà (Berguedà). A més d’ambdues finques, la ramaderia consta de més finques situades en municipis de la mateixa comarca, de comarques veïnes i d’una finca de regadiu a Salt (Gironès)

Characterization of human pancreatic orthotopic tumor xenografts suitable for drug screening

Background Efforts to identify novel therapeutic options for human pancreatic ductal adenocarcinoma (PDAC) have failed to result in a clear improvement in patient survival to date. Pancreatic cancer requires efficient therapies that must be designed and assayed in preclinical models with improved predictor ability. Among the available preclinical models, the orthotopic approach fits with this expectation, but its use is still occasional. Methods An in vivo platform of 11 orthotopic tumor xenografts has been generated by direct implantation of fresh surgical material. In addition, a frozen tumorgraft bank has been created, ensuring future model recovery and tumor tissue availability. Results Tissue microarray studies allow showing a high degree of original histology preservation and maintenance of protein expression patterns through passages. The models display stable growth kinetics and characteristic metastatic behavior. Moreover, the molecular diversity may facilitate the identification of tumor subtypes and comparison of drug responses that complement or confirm information obtained with other preclinical models. Conclusions This panel represents a useful preclinical tool for testing new agents and treatment protocols and for further exploration of the biological basis of drug responses.

Characterization of human pancreatic orthotopic tumor xenografts suitable for drug screening

Background Efforts to identify novel therapeutic options for human pancreatic ductal adenocarcinoma (PDAC) have failed to result in a clear improvement in patient survival to date. Pancreatic cancer requires efficient therapies that must be designed and assayed in preclinical models with improved predictor ability. Among the available preclinical models, the orthotopic approach fits with this expectation, but its use is still occasional. Methods An in vivo platform of 11 orthotopic tumor xenografts has been generated by direct implantation of fresh surgical material. In addition, a frozen tumorgraft bank has been created, ensuring future model recovery and tumor tissue availability. Results Tissue microarray studies allow showing a high degree of original histology preservation and maintenance of protein expression patterns through passages. The models display stable growth kinetics and characteristic metastatic behavior. Moreover, the molecular diversity may facilitate the identification of tumor subtypes and comparison of drug responses that complement or confirm information obtained with other preclinical models. Conclusions This panel represents a useful preclinical tool for testing new agents and treatment protocols and for further exploration of the biological basis of drug responses.

Implementació de programari de pràctiques d'introducció a la química quàntica i d'introducció a la programació en live CDs utilitzables pels alumnes fora de les aules

L'objectiu d'aquest projecte és desenvolupar live CDs per tal de facilitar als alumnes de les assignatures obligatòries del Departament de Química Física que inclouen pràctiques amb ordinadors el treball fora de les aules, com a complement del realitzar durant les sessions de pràctiques.

The Development of an Internal Testing Process for a Bluetooth Product

BlueGiga Technologies on uusi Bluetooth -teknologiaa soveltava pk-yritys. Yrityksen tuotekehitysprosessia täydentämään tarvittiin testausprosessi. Testausprosessin luominen oli haastavaa, koska Bluetooth -teknologia on uutta ja yritys on vielä nuori. Lisäksi se integroi kovo- ja ohjelmistokomponentteja tuotteissaan. Testaus aloitettiin evaluoimalla standardinmukaista tapaa dokumentoida testit. Tämän jälkeen tutkittiin BlueGigan ohjelmistokehitysprosessin suhdetta olemassa oleviin ohjelmistokehitysprosesseihin. Samanaikaisesti perehdyttiin Bluetooth -kvalifikaation testaukselle asettamiin vaatimuksiin. Tämän seurauksena TTCN:ää kokeiltiin helppolukuisen testitapauksen määrittelyssä. Käyttötapauksiin perustuvan testauksen sopivuutta Wireless Remote Access Platform:in (WRAP) testaamiseen arvioitiin kokeilemalla sitä Man-to-Machine -käyttötapauksen testaamisessa. Yllämainittujen tehtävien aikana kerätyn tiedon ja hankittujen kokemusten pohjalta laadittiin testausprosessi, joka kattaa yksikkö-, integraatio- ja järjestelmätason testauksen. Painopiste on järjestelmätason testauksessa. Prosessi määrittelee myös vastuuhenkilön tai -henkilöt eri testaustasoille.

Microbial diagnosis of bloodstream infection: towards molecular diagnosis directly from blood.

When a bloodstream infection (BSI) is suspected, most of the laboratory results-biochemical and haematologic-are available within the first hours after hospital admission of the patient. This is not the case for diagnostic microbiology, which generally takes a longer time because blood culture, which is to date the reference standard for the documentation of the BSI microbial agents, relies on bacterial or fungal growth. The microbial diagnosis of BSI directly from blood has been proposed to speed the determination of the etiological agent but was limited by the very low number of circulating microbes during these paucibacterial infections. Thanks to recent advances in molecular biology, including the improvement of nucleic acid extraction and amplification, several PCR-based methods for the diagnosis of BSI directly from whole blood have emerged. In the present review, we discuss the advantages and limitations of these new molecular approaches, which at best complement the culture-based diagnosis of BSI.

Goya's artwork imaging with Terahertz waves

In this paper we use a Terahertz (THz) time-domain system to image and analyze the structure of an artwork attributed to the Spanish artist Goya painted in 1771. The THz images show features that cannot be seen with optical inspection and complement data obtained with X-ray imaging that provide evidence of its authenticity, which is validated by other independent studies. For instance, a feature with a strong resemblance with one of Goya"s known signatures is seen in the THz images. In particular, this paper demonstrates the potential of THz imaging as a complementary technique along with X-ray for the verification and authentication of artwork pieces through the detection of features that remain hidden to optical inspection.

In vitro assays and clinical trials in red blood cell aging: Lost in translation.

The age of erythrocyte concentrates (EC) in transfusion medicine and the adverse outcomes when transfusing long-term-stored EC are highly controversial issues. Whereas the definition of a short-term-stored EC or a long-term-stored EC is unclear in clinical trials, data based on in vitro storage assays can help defining a limit in addition of the expiration date. The present review merges together these data in order to highlight an EC age cut-off and points out potential misleading consideration. The analysis of in vitro data highlights the presence of reversible and irreversible storage lesions and demonstrates that red blood cells (RBC) exhibit two limits during storage: one around 2 weeks and another one around 4 weeks of storage. Of particular importance, the first lesions to appear, i.e. the reversible ones, are per se reversible once transfused, whereas the irreversible lesions are not. In clinical trials, the EC age cut-off for short-term storage is in general fewer than 14 days (11 ± 4 days) and more disperse for long-term-stored EC (17 ± 13 days), regardless the clinical outcomes. Taking together, EC age cut-off in clinical trials does not totally fall into line of in vitro aging data, whereas it is the key criteria in clinical studies. Long-term-stored EC considered in clinical trials are not probably old enough to answer the question: "Does transfusion of long-term-stored EC (older than 4 weeks) result in worse clinical outcomes?" Depending on ethical concerns and clinical practices, older EC than currently assayed in clinical trials should have to be considered. These two worlds trying to understand the aging of erythrocytes and the impact on patients do not seem to speak the same language.

Metsäsektorin kehityksen vaikutus raaka-ainetarpeeseen ja rakenteeseen

Tutkimuksen tavoitteena on selvittää kuinka raakapuumarkkinat muodostuvat ja mitkä tekijät vaikuttavat raakapuun tarjontaan ja hankintaan. Lisäksi tarkastellaan onko tuontipuu korvaava vai täydentävä raaka-aine ja millainen rooli valtiovallalla on luodessaan yrityksille toimintaympäristöä. Työ on voimakkaasti teoreettispainotteinen. Teorian tarkoituksena on esittää se tieteellinen perusta, jolle raakapuumarkkinat sijoittuvat. Lisäksi on hyväksikäytetty aiemmin tehtyjä tutkimuksia, joiden tarkoituksena on valaista asiaa hieman käytännönläheisemmin. Työn tuloksena saadaan vastaukset tutkimuksen tavoitteisiin. Tulosten perusteella on ilmeistä, että keskeisin tarjontaan vaikuttava tekijä on puun hinta ja etenkin siihen liittyvät hintaodotukset. Kysyntään on puolestaan vaikuttanut teollisuuden kapasiteetin kehitys, tuotteiden menekki ja tuontipuun saatavuus. Tuotu koivukuitu on pikemminkin täydentänyt kuin korvannut kotimaan koivukuitua teollisuuden puun hankinnassa. Tuotu mäntykuitu toimii korvaavana tuotteena, mutta kuusikuidun kohdalla kotimaan hinnalla ei ole vaikutusta tuonnin määrään, ainoastaan tuontipuun omalla hinnalla näyttää olevan vaikutus tuontimäärään.

Toiminnanohjauksen kehittäminen toteutusaikataulun avulla

Tässä työssä tarkastellaan projektiin liittyvää toiminnanohjausta. Tutkimusongelmana on, kuinka toiminnanohjausta voitaisiin kehittää aikataulutuksen avulla. Työn yhtenä tavoitteena on luoda kokonaiskuva aikataulutuksen nykytilanteesta. Toisena tavoitteena on kartoittaa ajankohtaiset ongelmat. Kolmantena tavoitteena on luoda malli aikataulun laatimiselle kalanterin valmistuksessa.Kirjallisuustutkimuksen perusteella luotiin kuva projektiliiketoiminnasta ja projektinhallintaan sisältyvästä aikataulunhallinnasta. Haastattelututkimuksen perusteella luotiin kokonaiskuva projektin aikataulutuksesta ja siihen liittyvistä ongelmista. Tutkimusta täydennettiin analysoimalla erään projektin suunniteltua aikataulua ja toteutunutta aikataulua. Toiminnanohjauksen aikataulutustehtävä on muuttumassa yhä tarkeämmäksi toimittaessa resurssien äärirajoilla. Ajankohtaisia kysymyksiä ovat: toteutusaikataulun laatimistekniikka, projektin osittaminen, optimi suunnittelujärjestys ja kriittinen polku.Tutkimuksen perusteella kehitettiin toteutusaikataulun suunnittelun malli ja malliaikataulu. Mallin keskeiset osat ovat: projektin osittaminen tehtäviin, tärkeimpien tehtävien määrittäminen tarkempaa ohjausta varten, tehtävien välisten riippuvuuksien määrittäminen, tehtävien limitysmahdollisuuksien ja ajallisen keston arviointi, aikataulun esittäminen janakaaviona ja ulkoisten tekijöiden, kuten hankinnan asettamien vaatimusten huomioiminen malliaikataulussa. Malliaikataulua tullaan soveltamaan seuraavaan sopivaan toimitusprojektiin.

Postmortem diagnosis of diabetes mellitus and its complications.

Diabetes mellitus has become a major cause of death worldwide and diabetic ketoacidosis is the most common cause of death in children and adolescents with type 1 diabetes. Acute complications of diabetes mellitus as causes of death may be difficult to diagnose due to missing characteristic macroscopic and microscopic findings. Biochemical analyses, including vitreous glucose, blood (or alternative specimen) beta-hydroxybutyrate, and blood glycated hemoglobin determination, may complement postmortem investigations and provide useful information for determining the cause of death even in corpses with advanced decompositional changes. In this article, we performed a review of the literature pertaining to the diagnostic performance of classical and novel biochemical parameters that may be used in the forensic casework to identify disorders in glucose metabolism. We also present a review focusing on the usefulness of traditional and alternative specimens that can be sampled and subsequently analyzed to diagnose acute complications of diabetes mellitus as causes of death.

Local Salmonella immunostimulation recruits vaccine-specific CD8 T cells and increases regression of bladder tumor.

NlmCategory="UNASSIGNED">The efficacy of antitumoral responses can be increased using combinatorial vaccine strategies. We recently showed that vaccination could be optimized by local administration of diverse molecular or bacterial agents to target and augment antitumoral CD8 T cells in the genital mucosa (GM) and increase regression of cervical cancer in an animal model. Non muscle-invasive bladder cancer is another disease that is easily amenable to local therapies. In contrast to data obtained in the GM, in this study we show that intravesical (IVES) instillation of synthetic toll-like receptor (TLR) agonists only modestly induced recruitment of CD8 T cells to the bladder. However, IVES administration of Ty21a, a live bacterial vaccine against typhoid fever, was much more effective and increased the number of total and vaccine-specific CD8 T cells in the bladder approximately 10 fold. Comparison of chemokines induced in the bladder by either CpG (a TLR-9 agonist) or Ty21a highlighted the preferential increase in complement component 5a, CXCL5, CXCL2, CCL8, and CCL5 by Ty21a, suggesting their involvement in the attraction of T cells to the bladder. IVES treatment with Ty21a after vaccination also significantly increased tumor regression compared to vaccination alone, resulting in 90% survival in an orthotopic murine model of bladder cancer expressing a prototype tumor antigen. Our data demonstrate that combining vaccination with local immunostimulation may be an effective treatment strategy for different types of cancer and also highlight the great potential of the Ty21a vaccine, which is routinely used worldwide, in such combinatorial therapies.

Belleza y elocuencia, o la rendición por los sentidos (Lucianus, Scyth. 11)

In Lucian Scythian (§11), all previous editors have corrected the word ¢p£xetai as it appears in the manuscripts to p£xetai. We aim to justify the restoration of the original text because, obviously, it is possible in terms of form, and, besides, it seems more appropriate to the context. The verb ¢p£gomai implies the notion of being moved from one place to another, while p£gomai expresses only the notion of simple attraction which does not involve actual movement. This notion of true surrendering through the senses seems to match the idea developed here by Lucian; loci paralleli in Lucian himself and other Attic authors help us to confirm this interpretation.