Comparação da ocorrência de complicações tromboembólicas e hemorrágicas em pacientes portadores de prótese valvares cardíacas mecânicas com um e dois folhetos na posição mitral

Introdução: Pacientes portadores de próteses valvares cardíacas mecânicas devem medicados continuamente com anticoagulantes orais para evitar acidentes tromboembólicos. Estes pacientes são avaliados continuamente para o controle da anticoagulação oral. Objetivo: Comparar a ocorrência de complicações tromboembólicas e hemorrágicas em portadores de próteses valvares cardíacas mecânicas de um (mono) e de dois (bi) folhetos na posição mitral em terapêutica anticoagulante. Métodos: Foram estudados, no intervalo de 10 anos, 117 pacientes portadores de prótese na posição mitral, sendo 48 com próteses de folheto único e 69 de folheto duplo. Avaliou-se a ocorrência de complicações tromboembólicas e hemorrágicas de grau maior e menor de acordo com a gravidade. Os resultados estão apresentados sob forma de estudo atuarial e de frequência linearizada de ocorrência de eventos. Resultados: As curvas atuariais mostraram que, ao longo do tempo, os pacientes portadores de próteses valvares monofolheto estiveram menos livres de complicações tromboembólicas que os pacientes com próteses bifolheto, enquanto que, estes últimos (bifolheto) estiveram menos livres de acidentes hemorrágicos. As frequências linearizadas de ocorrência para tromboembolismo foram maiores nos pacientes com próteses monofolheto. Nos episódios hemorrágicos as taxas foram maiores para os portadores de próteses bifolheto. Conclusão: Os portadores de próteses valvares cardíacas monofolheto mostraram-se mais propensos à ocorrência de acidentes tromboembólicos graves em relação aos com próteses bi folheto. Os pacientes com prótese bifolheto apresentaram maior sangramento que os pacientes com prótese monofolheto, no entanto, esta diferença se restringiu aos sangramentos de pouca gravidade.

Internal Combustion Engine's Throttle Control as a Motivational Theme for Teaching Microprocessors Systems Lab Classes

The increased fuel economy and driveability of modern internal combustion engine vehicles (ICEVs) are the result of the application of advanced digital electronics to control the operation of the internal combustion engine (ICE). Microprocessors (and micro controllers) play a key role in the engine control, by precisely controlling the amount of both air and fuel admitted into the cylinders. Air intake is controlled by utilizing a throttle valve equipped with a motor and gear mechanism as actuator, and a sensor enabling the measurement of the angular position of the blades. This paperwork presents a lab setup that allows students to control the throttle position using a microcontroller that runs a program developed by them. A commercial throttle body has been employed, whereas a power amplifier and a microcontroller board have been hand assembled to complete the experimental setup. This setup, while based in a high-tech, microprocessor-based solution for a real-world, engine operation optimization problem, has the potential to engage students around a hands-on multidisciplinary lab activity and ignite their interest in learning fundamental and advanced topics of microprocessors systems.

Patient with a Starr-Edwards Prosthesis in the Aortic Position for 40 Years

Herein is reported the case of a patient who presented initially with aortic insufficiency and a fistula between the sinus of Valsalva and right atrium when aged 31 years. Closure of the fistula and replacement of the aortic valve with a Starr-Edwards A-9 caged-ball prosthesis was performed in 1972, since when the valve has survived for 40 years without dysfunction. This is one of the longest follow ups of the Starr-Edwards prosthesis reported, and highlights the possibility of acceptable valve performance over long periods of time.

Left ventricular sphericity index predicts systolic dysfunction in rats with experimental aortic regurgitation

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Functional Morphology of the Crop and Proventriculus of Sitophilus zeamais (Coleoptera: Curculionidae)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Influência da dieta hiperlipídica ricas em ácidos graxos saturados sobre o metabolismo, estrutura e função cardíaca de ratos com estenose aórtica supravalvar

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Double-lumen catheter in the right jugular vein induces two sub-endothelial abscesses in an unusual place, the transition between the superior vena cava and the right atrium: a case report

Endocarditis is a type of infection that is common in internal medicine wards and in haemodialysis clinics. The location that is most affected are the heart valves. Herein, we report a case of an uncommon abscess, a sub-endothelial abscess between the transition of the superior vena cava and the right atrium. There were several emboli to the lung and foot, and the agent was related to Staphylococcus aureus and a double-lumen catheter. Usually, this type of abscess is located in valves, either the tricuspid valve if related to catheters or injection drug use or the mitral valve if related to other causes. An exhaustive review was made, but we found no information about the location of this abscess and the rarity of the event motivating the report of infection.

Modelagem e otimização por metodologia de superfícies de resposta: um estudo em arames de aço SAE 9254 para molas automobilísticas

Pós-graduação em Engenharia Mecânica - FEG

Pressure distribution on the frontal disk for turbulent flows in a radial diffuser

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Parasitoid-host interaction: sensory structures involved in the parasitism behavior of Bracon vulgaris (Hymenoptera: Braconidae)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Echocardiographic and radiographic aspects of tetralogy of Fallot in a Border Collie: case report

Tetralogy of Fallot is a complex cardiac malformation characterized by four anatomical defects: pulmonary valve stenosis, right ventricular hypertrophy, interventricular septal defect and aortic dextroposition. Imaging techniques are useful in the diagnosis of this disease, such as radiography for screening and Doppler echocardiography for a definitive diagnosis. Our objective is to report the radiographic and Doppler echocardiographic aspects of a tetralogy of Fallot case in a 10 month-old Border Collie dog.

Estudo e modelagem 3D de um cabeçote para um motor monocilíndrico, 400cc, 4 T

The cylinder head contains the combustion chamber for the air-fuel mixture and the intake and exhaust valves, the valve guide and the valve seat. The cylinder head also is a support for the camshaft and valve rocker. The holes where the spark plugs are connected are designed to fit the better place in the combustion chamber. The cylinder heads often are manufactured using materials such as aluminum and cast iron. The cooling fins located in the outside of the cylinder head are designed for a good heat transfer and therefore their dimensions and positioning are important. This work aims the calculation for a cylinder head to be installed in a 400 cc displacement, gasoline powered, four stroke, single cylinder engine. According to the displacement it will be analyzed the combustion chamber, the intake and exhaust valves, as well as the camshaft and rocker arms. This also a work to help to accomplish the design of a single cylinder engine, where the alternatives parts, cylinder block and crankcase are all already machined and assembled in this campus

Mensuração do volume atrial esquerdo pelo método biplanar de Simpson em cães portadores da doença mixomatosa da válvula mitral

Pós-graduação em Medicina Veterinária - FCAV

Lactato sanguíneo em cães com insuficiência cardíaca congestiva decorrente de degeneração valvular mitral

Pós-graduação em Medicina Veterinária - FCAV

Como estará a ingestão de sódio após uma sobrecarga de volume combinada ao tratamento com paroxetina?

Aortic regurgitation (AR) is still common in developing countries as secondary of rheumatic fever, and its incidence have increased in senile degenerative form. The AR develops severe myocardial hypertrophy. A common comorbidity associated with cardiovascular disease is depression. Among the most prescribed antidepressants in the world are the serotonin selective reuptake inhibitors (SSRIs). Central serotonergic pathways are involved with the inhibition of sodium intake and can be modify the excretion of this íon. Therefore, we investigated whether treatment with an antidepressants SSRI, the paroxetine, for four weeks can modfy the behavior of water and NaCl 0,3M intake, excretion of sodium and morphofunctional parameters of rats with AR induce. Wistar rats (280 - 300g) underwent surgery for AR (n=15) or control surgery (n=14). The AR was induced by retrograde puncture of valve leaflets. The animals were divided into 4 groups: AR + paroxetine (n=8), AR + control (n=7), control + paroxetine (n=7), control + control (n=7). From the 4th to the 8th week after inductuin of AR was administered paroxetine (10mg/kg pc) daily and subcutaneously. In the 4th and 8th week after induction of AR echocardiograms were performed to collect data morphofunctional. During the 4 weeks of treatment were analyzed intake of water and saline daily and once a week urine samples were collected for analysis by flame photometer of excretion of sodium and potassium. In the 10th week the animals were submitted to a challenge protocol hidromineral by combining furosemide (10 mg / kg bw) associated with the low dose of Captopril (5 mg / kg bw). During the challenged urine samples were collected for analysis by flame photometer of excretion of sodium and potassium at the time zero and after 2 hours of treatment. As a result we found that treatment with paroxetine in rats with AR determined an improvement in fractional shortening (shortening fraction: 52.7 ± 2.2% vs. RA ...