High-precision U-Pb and 40Ar/39Ar dating of an Alpine ophiolite (Gets nappe, French Alps)

Coarse-grained gabbros from two different localities in the Gets nappe (Upper Prealps) have been dated by U-Pb and Ar-40/Ar-39 isotopic analyses. Zircons from both gabbros gave identical concordant U-Pb ages of 166 +/- 1 Ma (Fig. 4). Amphibole from one of them gave an Ar-40/Ar-39 plateau age of 165.9 +/- 2.2 Ma (Fig. 5). This concordance implies that 166 +/- 1 Ma is the age of magmatic crystallization of these gabbros. The Gets wildflysch with its mafic and ultramafic lenses is an ophiolitic melange, that we infer to come from a proximal part of the accretionary prism at the foot of the active SE margin of the Piemont ocean. In this position we can expect to find remnants of the oldest parts of the Piemont oceanic crust. These are the first high-precision dates using modern techniques from an Alpine ophiolite and are in excellent agreement with the following: 1) The few, somewhat younger, reliable ages on ophiolites from the probable continuation of the Piemont basin into the Apennines and Corsica; 2) Recent data on the age of the first supra-ophiolitic sediments (Late Bathonian to Early Callovian radiolarites); 3) The structural and stratigraphic evolution of the Brianconnais (s.s.) domain, the future NW margin of the Piemont ocean. We note a remarkable coincidence, in Late Bajocian time, between: (A) the end of tensile fracturing in the Brianconnais continental crust; (B) the beginning of its subsidence; (C) the age of the Gets ophiolites. This coincidence is consistent with an ocean opening mechanism based on a combination of subhorizontal extension and thermally driven vertical movements of the lithosphere.

A comparative long-memory Analysis between Spanish, Mexican and U.S. interest rates

Evidence exists that many natural facts are described better as a fractal. Although fractals are very useful for describing nature, it is also appropiate to review the concept of random fractal in finance. Due to the extraordinary importance of Brownian motion in physics, chemistry or biology, we will consider the generalization that supposes fractional Brownian motion introduced by Mandelbrot.The main goal of this work is to analyse the existence of long range dependence in instantaneous forward rates of different financial markets. Concretelly, we perform an empirical analysis on the Spanish, Mexican and U.S. interbanking interest rate. We work with three time series of daily data corresponding to 1 day operations from 28th March 1996 to 21st May 2002. From among all the existing tests on this matter we apply the methodology proposed in Taqqu, Teverovsky and Willinger (1995).

Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial.

BACKGROUND: Cilengitide is a selective αvβ3 and αvβ5 integrin inhibitor. Data from phase 2 trials suggest that it has antitumour activity as a single agent in recurrent glioblastoma and in combination with standard temozolomide chemoradiotherapy in newly diagnosed glioblastoma (particularly in tumours with methylated MGMT promoter). We aimed to assess cilengitide combined with temozolomide chemoradiotherapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter. METHODS: In this multicentre, open-label, phase 3 study, we investigated the efficacy of cilengitide in patients from 146 study sites in 25 countries. Eligible patients (newly diagnosed, histologically proven supratentorial glioblastoma, methylated MGMT promoter, and age ≥18 years) were stratified for prognostic Radiation Therapy Oncology Group recursive partitioning analysis class and geographic region and centrally randomised in a 1:1 ratio with interactive voice response system to receive temozolomide chemoradiotherapy with cilengitide 2000 mg intravenously twice weekly (cilengitide group) or temozolomide chemoradiotherapy alone (control group). Patients and investigators were unmasked to treatment allocation. Maintenance temozolomide was given for up to six cycles, and cilengitide was given for up to 18 months or until disease progression or unacceptable toxic effects. The primary endpoint was overall survival. We analysed survival outcomes by intention to treat. This study is registered with ClinicalTrials.gov, number NCT00689221. FINDINGS: Overall, 3471 patients were screened. Of these patients, 3060 had tumour MGMT status tested; 926 patients had a methylated MGMT promoter, and 545 were randomly assigned to the cilengitide (n=272) or control groups (n=273) between Oct 31, 2008, and May 12, 2011. Median overall survival was 26·3 months (95% CI 23·8-28·8) in the cilengitide group and 26·3 months (23·9-34·7) in the control group (hazard ratio 1·02, 95% CI 0·81-1·29, p=0·86). None of the predefined clinical subgroups showed a benefit from cilengitide. We noted no overall additional toxic effects with cilengitide treatment. The most commonly reported adverse events of grade 3 or worse in the safety population were lymphopenia (31 [12%] in the cilengitide group vs 26 [10%] in the control group), thrombocytopenia (28 [11%] vs 46 [18%]), neutropenia (19 [7%] vs 24 [9%]), leucopenia (18 [7%] vs 20 [8%]), and convulsion (14 [5%] vs 15 [6%]). INTERPRETATION: The addition of cilengitide to temozolomide chemoradiotherapy did not improve outcomes; cilengitide will not be further developed as an anticancer drug. Nevertheless, integrins remain a potential treatment target for glioblastoma. FUNDING: Merck KGaA, Darmstadt, Germany.

Panorama de la Compagnie générale transatlantique peint par Th Poilpot. Dioaramas ... Exposition universelle 1889, quai d'Orsay... : [affiche] / [non signée]

Référence bibliographique : Broido 502

[Illustrations de Sur les routes du monde. Récits pour la jeunesse.] / Madame André Barnaud-Ellenberger, dess. ; Th. Burnier, aut. du texte

Comprend : [Fig. p.9 : navire.] A toutes voiles. [Cote : 16 ° G 987/Microfilm R 122011] ; [Fig. p.15 : poissons volants.] [Cote : 16 ° G 987/Microfilm R 122011] ; [Fig. p.19 : côtes de l'Afrique.] [Cote : 16 ° G 987/Microfilm R 122011] ; [Fig. p.24 : le pont d'un navire dans la tempête.] Tempêtes et guerres. [Cote : 16 ° G 987/Microfilm R 122011] ; [Fig. p.28 : navire dans une tempête.] [Cote : 16 ° G 987/Microfilm R 122011] ; [Fig. p.41 : un train en Afrique.] [Cote : 16 ° G 987/Microfilm R 122011] ; [pl. p.47 : girafes se blessant sur les fils des poteaux électriques.] [Cote : 16 ° G 987/Microfilm R 122011] ; [pl. en reg. p.55 : convoi tiré par des boeufs au zambèze, dans la région de Buluwayo.] En wagon à boeufs. [Cote : 16 ° G 987/Microfilm R 122011] ; [Fig. p.57 : pièce de l'attelage des convois à boeufs du Zambèze.] [Cote : 16 ° G 987/Microfilm R 122011] ; [Fig. p.71 : une pirogue sur le fleuve zambèze.] En pirogue. [Cote : 16 ° G 987/Microfilm R 122011] ; [Fig. p.73 : les variétés d'oiseaux du Zambèze.] [Cote : 16 ° G 987/Microfilm R 122011] ; [Fig. p.75 : crocodiles du Zambèze.] [Cote : 16 ° G 987/Microfilm R 122011] ; [Fig. p.79 : campement sur les bords du Zambèze.] [Cote : 16 ° G 987/Microfilm R 122011] ; [Fig. p.86 : un pagayeur Africain.] [Cote : 16 ° G 987/Microfilm R 122011] ; [Fig. p.90 : missionnaire en Afrique.] [Cote : 16 ° G 987/Microfilm R 122011]