Algoritmos multi-objetivos para la optimización de una secuencia de matrices generadoras en computación cuántica topológica

Quantum Computing is a relatively modern field which simulates quantum computation conditions. Moreover, it can be used to estimate which quasiparticles would endure better in a quantum environment. Topological Quantum Computing (TQC) is an approximation for reducing the quantum decoherence problem1, which is responsible for error appearance in the representation of information. This project tackles specific instances of TQC problems using MOEAs (Multi-objective Optimization Evolutionary Algorithms). A MOEA is a type of algorithm which will optimize two or more objectives of a problem simultaneously, using a population based approach. We have implemented MOEAs that use probabilistic procedures found in EDAs (Estimation of Distribution Algorithms), since in general, EDAs have found better solutions than ordinary EAs (Evolutionary Algorithms), even though they are more costly. Both, EDAs and MOEAs are population-based algorithms. The objective of this project was to use a multi-objective approach in order to find good solutions for several instances of a TQC problem. In particular, the objectives considered in the project were the error approximation and the length of a solution. The tool we used to solve the instances of the problem was the multi-objective framework PISA. Because PISA has not too much documentation available, we had to go through a process of reverse-engineering of the framework to understand its modules and the way they communicate with each other. Once its functioning was understood, we began working on a module dedicated to the braid problem. Finally, we submitted this module to an exhaustive experimentation phase and collected results.

Contributions on distance-based algorithms, multi-classifier construction and pairwise classification

179 p.

Prediction of Multi-Target Networks of Neuroprotective Compounds with Entropy Indices and Synthesis, Assay, and Theoretical Study of New Asymmetric 1,2-Rasagiline Carbamates

In a multi-target complex network, the links (L-ij) represent the interactions between the drug (d(i)) and the target (t(j)), characterized by different experimental measures (K-i, K-m, IC50, etc.) obtained in pharmacological assays under diverse boundary conditions (c(j)). In this work, we handle Shannon entropy measures for developing a model encompassing a multi-target network of neuroprotective/neurotoxic compounds reported in the CHEMBL database. The model predicts correctly >8300 experimental outcomes with Accuracy, Specificity, and Sensitivity above 80%-90% on training and external validation series. Indeed, the model can calculate different outcomes for >30 experimental measures in >400 different experimental protocolsin relation with >150 molecular and cellular targets on 11 different organisms (including human). Hereafter, we reported by the first time the synthesis, characterization, and experimental assays of a new series of chiral 1,2-rasagiline carbamate derivatives not reported in previous works. The experimental tests included: (1) assay in absence of neurotoxic agents; (2) in the presence of glutamate; and (3) in the presence of H2O2. Lastly, we used the new Assessing Links with Moving Averages (ALMA)-entropy model to predict possible outcomes for the new compounds in a high number of pharmacological tests not carried out experimentally.

Le système monétaire international comme facteur d'instabilité: une ébauche de réforme

371 p.