Sonic hedgehog signaling regulates mode of cell division of early cerebral cortex progenitors and increases

The morphogen Sonic Hedgehog (SHH) plays a critical role in the development of different tissues. In the central nervous system, SHH is well known to contribute to the patterning of the spinal cord and separation of the brain hemispheres. In addition, it has recently been shown that SHH signaling also contributes to the patterning of the telencephalon and establishment of adult neurogenic niches. In this work, we investigated whether SHH signaling influences the behavior of neural progenitors isolated from the dorsal telencephalon, which generate excitatory neurons and macroglial cells in vitro. We observed that SHH increases proliferation of cortical progenitors and generation of astrocytes, whereas blocking SHH signaling with cyclopamine has opposite effects. In both cases, generation of neurons did not seem to be affected. However, cell survival was broadly affected by blockade of SHH signaling. SHH effects were related to three different cell phenomena: mode of cell division, cell cycle length and cell growth. Together, our data in vitro demonstrate that SHH signaling controls cell behaviors that are important for proliferation of cerebral cortex progenitors, as well as differentiation and survival of neurons and astroglial cells.

Simulación de un enlace óptico WDM (Wavelength Division Multiplexing) utilizando POFs (Polymer Optical Fiber) en el espectro de luz visible

En este proyecto se analizaron las características y el modo de operación de las fibras ópticas plásticas en un enlace óptico WDM (Wavelenght Division Multiplexing) operando en el espectro visible. Se estudiaron los componentes activos y pasivos necesarios para el enlace, como son las fuentes LED, multiplexores, filtros y acopladores. Se analizaron los efectos no lineales que se pueden presentar en la fibra óptica, y que son importantes de considerar al transmitir señales WDM. Para respaldar el análisis se simuló en MATLAB un enlace óptico en el dominio de la frecuencia utilizando fuentes LED que emiten en el espectro visible, junto con multiplexores WDM, filtros de absorción, acopladores y como medio de transmisión la Fibra Óptica Plástica (POF -Plastic Optical Fiber).

Annual report of the Division of Apprenticeship.

Report year ends June 30.

DETERMINANTS OF THE ADOPTION OF INTEGRATED SOIL FERTILITY MANAGEMENT TECHNOLOGIES IN MBALE DIVISION, KENYA

The agro-climatic conditions in western Kenya present the region as a food surplus area yet people are still reliant on food imports, with the region registering high poverty levels. Depletion of soil fertility and the resulting decline in agricultural productivity in Mbale division has led to many attempts to develop and popularize Integrated Soil Fertility Management (ISFM) technologies that could restore soil fertility. These technologies bridge the gap between high external inputs and extreme forms of traditional low external input agriculture. Some of the ISFM components used by farmers are organic and inorganic inputs and improved seeds. However, the adoption of these technologies is low. The study aimed to examine the factors that influence the adoption of ISFM technologies by smallholder farmers in Mbale division, Kenya. The study was conducted in 9 sub-locations in Mbale division. Purposive sampling was used in selecting the 80 farmers to get the data based on a farm-household survey. Self-administered questionnaires were used to collect data on the determinants of the adoption of ISFM technologies from the sampled farmers in the study area. The study sought to answer the research question: What factors influence the uptake of ISFM technologies by farmers in Mbale division? The hypothesis tested was that the adoption of ISFM technologies is not influenced by age, education, extension services, labour, off-farm income and farm size. Data was analyzed using descriptive statistics. Cross tabulation was used for examining the relationship between categorical (nominal or ordinal) variables, and the bivariate correlations procedure was used to compute the pair wise associations between scale or ordinal variables. Probit regression was used to predict the socio-economic factors influencing the adoption of ISFM technologies among smallholder farmers. Results of the study indicated that education of household head, membership in social groups, age of the household head, off-farm income and farm size were the variables that significantly influenced the adoption of ISFM technologies. The findings show that there is need for a more pro-poor focused approach to achieve sustainable soil fertility management among smallholder farmers. The findings will help farmers, extension officers, researchers and donors in identifying region-specific entry points that can help in developing innovative ISFM technologies.

Developpement et industralisation de l'economie portugaise dans le contexte de la division internationale du travail.

Doutoramento em Economia.

Digit recurence division under HUB format

Half-Unit-Biased format is based on shifting the representation line of the binary numbers by half Unit in the Last Place. The main feature of this format is that the round to nearest is carried out by a simple truncation, preventing any carry propagation and saving time and area. Algorithms and architectures have been defined for addition/substraction and multiplication operations under this format. Nevertheless, the division operation has not been confronted yet. In this paper we deal with the floating-point division under HUB format, studying the architecture for the digit recurrence method, including the on-the-fly conversion of the signed digit quotient.

An efficient mapreduce-based parallel clustering algorithm for distributed traffic subarea division

Traffic subarea division is vital for traffic system management and traffic network analysis in intelligent transportation systems (ITSs). Since existing methods may not be suitable for big traffic data processing, this paper presents a MapReduce-based Parallel Three-Phase K -Means (Par3PKM) algorithm for solving traffic subarea division problem on a widely adopted Hadoop distributed computing platform. Specifically, we first modify the distance metric and initialization strategy of K -Means and then employ a MapReduce paradigm to redesign the optimized K -Means algorithm for parallel clustering of large-scale taxi trajectories. Moreover, we propose a boundary identifying method to connect the borders of clustering results for each cluster. Finally, we divide traffic subarea of Beijing based on real-world trajectory data sets generated by 12,000 taxis in a period of one month using the proposed approach. Experimental evaluation results indicate that when compared with K -Means, Par2PK-Means, and ParCLARA, Par3PKM achieves higher efficiency, more accuracy, and better scalability and can effectively divide traffic subarea with big taxi trajectory data.

Supersession of the senior-most judges in Bangladesh in appointing the chief justice and the other judges of the appellate division of the supreme court : a convenient means to a politicized bench

The Constitution of Bangladesh has provided the President with the unfettered power to appoint the Chief Justice of Bangladesh. However, the President is required by the Constitution to act on the advice of the Prime Minister, after consulting the Chief Justice, in appointing the puisne judges of the Supreme Court - the apex court of the nation. This Article finds that in the absence of any specific constitutional provisions specifying that the senior-most judge of the Appellate Division - the higher Division of the Supreme Court - should be appointed as the Chief Justice, a convention to this effect was developed for ensuring that extraneous considerations did not play a part in the pivotal appointment of the Chief Justice. In the same vein, a convention of appointing the senior-most judges of the High Court Division, which is the lower Division of the Supreme Court, as the judges of the Appellate Division was developed. But both these conventions have been transgressed at regular intervals by succeeding generations of executives, particularly by the current one, for politicizing the superior judiciary of the nation, thereby undermining its credibility in the eyes of the litigants as an impartial arbitrator of disputes. Accordingly, this article concludes that in order to exclude the possibility of appointments on extraneous considerations, the principles of appointing the Chief Justice and the other judges of the Appellate Division on the basis of seniority should be inserted in the Constitution by means of an amendment.

Iowa Attorney General's Crime Victim Assistance Division Annual Report SFY2014, January 15, 2015

The Crime Victim Assistance Division (CVAD) was created by the Iowa General Assembly and founded by Attorney General Tom Miller in July 1989. In 1989, the Division administered two programs with six staff. Today, CVAD administers eight programs with 24 staff. This is the annual report for SFY2014.

Iowa Attorney General's Crime Victim Assistance Division: Three Year Program Reports Fiscal Years 2011, 2012, 2013 July 1, 2010 through June 2013, December 2014

We are pleased to present this report of our work and accomplishments on behalf of crime victims and survivors. The eight programs of the CVAD served over 225,000 Iowa crime victims over SFY11, SFY12 & SFY13. This report statistically outlines the services being provided in each of these individual programs. CVAD Staff and funded victim service providers work day in and day out to provide essential, victim-centered services to those who have been harmed by violent crime. This report aims to capture the work being performed around the State of Iowa with CVAD funds. Significant accomplishments have occurred during this reporting period, including the initial planning phases of a restructuring of domestic violence, sexual assault, shelter-based and homicide survivor programming and services; enhancements in automated victim notification and continued strides in restitution collection.

STATE OF SOUTH CAROLINA OFFICE OF THE GOVERNOR DIVISION OF FOSTER CARE REVIEW ANNUAL REPORT - 1994-95

The South Carolina Foster Care Review Board at the Office of Executive Policy and Programs annually publishes a report with summary of programs, recommendations, demographic and statistical information, and directory of state board and staff.

OFFICE OF THE GOVERNOR DIVISION OF FOSTER CARE REVIEW 1996-1997 ANNUAL REPORT

The South Carolina Foster Care Review Board at the Office of Executive Policy and Programs annually publishes a report with summary of programs, recommendations, demographic and statistical information, and directory of state board and staff.

OFFICE OF THE GOVERNOR DIVISION OF FOSTER CARE REVIEW 1998-1999 ANNUAL REPORT

The South Carolina Foster Care Review Board at the Office of Executive Policy and Programs annually publishes a report with summary of programs, recommendations, demographic and statistical information, and directory of state board and staff.

Into the Spotlight: Bringing Transparency, Consistency, and Efficiency to the Division of Appeals and Hearings

Currently, the Division of Appeals and Hearings of the South Carolina Department of Health and Human Services has no specific presence on the agency's website to provide information or to allow for the electronic submission of appeals. This project's focus was developing an online presence for the Division on SCDHHS' website. The page will make the Division's procedures publicly available to beneficiaries, providers, and agency program staff who attend hearings. Additionally, parties will have a secure online portal through which they can file appeals and upload supporting documentation, reducing the need to send appeals via first class mail. The online appeal portal will further the agency' s goal of reducing paper.