Engaging teachers : towards a radical democratic agenda for schooling

Engaging Teachers' makes a deliberate attempt to reclaim the education discourse captured by new right politics and connect it with a radical democratic agenda for schooling. On its agenda are education markets, policy, leadership, professionalism, and communities. Engaging with these is conceived on at least two levels. First, as an invitation to teachers to become involved in reconstructing schooling for socially just purposes and in democratic ways. From this perspective, the politics of engagement is not simply a matter of acquiescence or resistance but is informed by a commitment to generate alternatives: teachers, parents and students making things happen rather than having things done to them. Also signalled is an intent to work collectively, exploring and acting on common interests and across uncommon ground. Second, the book also celebrates teachers engaging in these reconstructive efforts in attractive and meaningful ways. The attraction is decisions about schooling made by those they affect as well as decisions that are meaningful because they engage the interests of all.

Optimization of polymerization conditions and thermal degradation of conducting polypyrrole coated polyester fabrics

PET fabric is coated with conducting polypyrrole (PPy) by oxidative polymerization from an aqueous solution of Py using ferric chloride hexahydrate (FeCl3) as oxidant and p-toluene sulphonate (pTSA) as dopant. The optimum concentrations for Py, FeCl3 and pTSA were found to be 0.11, 0.857 and 0.077 mol/l respectively, which yielded a conductive fabrics with resistivity as low as 72 Ω/sq. PPy fabric gained resistivity less than one order of magnitude when aged for 18 months at room temperature. The stabilizing effect of the dopant pTSA against thermal degradation was demonstrated; the undoped samples reached resistivity of around 40 kΩ, whereas doped samples reached less than 2 kΩ at the same temperature and time.

8-modified-2'-deoxyadenosine analogues induce delayed polymerization arrest during HIV-1 reverse transcription

The occurrence of resistant viruses to any of the anti-HIV-1 compounds used in the current therapies against AIDS underlies the urge for the development of new drug targets and/or new drugs acting through novel mechanisms. While all anti-HIV-1 nucleoside analogues in clinical use and in clinical trials rely on ribose modifications for activity, we designed nucleosides with a natural deoxyribose moiety and modifications of position 8 of the adenine base. Such modifications might induce a steric clash with helix αH in the thumb domain of the p66 subunit of HIV-1 RT at a distance from the catalytic site, causing delayed chain termination. Eleven new 2′-deoxyadenosine analogues modified on position 8 of the purine base were synthesized and tested in vitro and in cell-based assays. In this paper we demonstrate for the first time that chemical modifications on position 8 of 2′-deoxyadenosine induce delayed chain termination in vitro, and also inhibit DNA synthesis when incorporated in a DNA template strand. Furthermore, one of them had moderate anti-HIV-1 activity in cell-culture. Our results constitute a proof of concept indicating that modification on the base moiety of nucleosides can induce delayed polymerization arrest and inhibit HIV-1 replication.

One step multifunctional micropatterning of surfaces using asymmetric glow discharge plasma polymerization

Micropatterning of surfaces with varying chemical, physical and topographical properties usually requires a number of fabrication steps. Herein, we describe a micropatterning technique based on plasma enhanced chemical vapour deposition (PECVD) that deposits both protein resistant and protein repellent surface chemistries in a single step. The resulting multifunctional, selective surface chemistries are capable of spatially controlled protein adhesion, geometric confinement of cells and the site specific confinement of enzyme mediated peptide self-assembly.

Creative research : a radical subjectivity?

The struggles around notions of creative research are in some ways engaged with the return of the subject in face of post/structuralist moves that have tried to evacuate or dissolve subjectivity, or reduce it to an element in a structure. What this kind of subjectivity is, and how to define it, seems a matter up for grabs. What I suggest is that creative research is trying to stretch beyond its boundaries by advocating for a knowledge-producing subjectivity that rejects the methodological positivism of so called real research (which in many ways is centred upon the presuppostition of a transcendental subject), while negotiating the discourses of postmodernity and post/structuralism which are suspicious of, or radically dismiss, subjectivity as a category. I suggest that creative research might be a radical gesture, indeed a radical subjectivity, whose possibilities as creative/critical practices reveal the human content of the seemingly autonomous forms which are the outcome of the fragmentary world of capitalist social relations.

Radical practice? Writing 'beyond' system

Might writing be at once the context or system that restricts and forms us but also, in some instances, the means to evade or transform this very system? The question posed in the call for papers for this conference outlines the very grounds upon which the writing subject may be seen as negotiating questions posed by artistic practice and creative research. Here these are formulated around ‘encounters’ between seemingly autonomous or pre-determined realms: between subjects and objects, between knowing and being, between aesthetic systems however defined. This view accepts the fragmentary definitional world of capitalist social relations. What I suggest is that the kind of subject that is at stake in creative practice and research has much in common with a kind of radical subjectivity. What I suggest is that writing is a practice that can be seen through the lens of Karl Marx’s notion of purposeful activity. Writing, in other words, is a critical/creative practice founding a radical view of subjectivity that attempts to overcome the dualism of subject and object via the category of human practice. Against an individual expressivist paradigm, or modes of thought that envision writing (and language) objectively, this might be called radical practice in that writing is a critical/creative practice: critical in that it is against what exists, and creative in that it seeks to move beyond it.

Tuning radical species in graphene oxide in aqueous solution by photoirradiation

Graphene oxide (GO) possesses unusual electronic and mechanical properties, including the ability to stabilize graphene radicals (GRs). However, controlled generation of GRs remains a challenge for applications requiring large-scale production. In this study, we demonstrate controlled production of GRs by UVB irradiation of GO solutions. Electron paramagnetic resonance spectroscopy of GO solutions revealed a dose-dependent exponential growth in radical production as a function of UVB exposure time. The GRs were air-stable over a long period, both in the solution state and in freeze-dried powders, suggesting they are graphene-based phenalenyl-like radicals. The redox activity of GRs was demonstrated by their ability to oxidize the chromophore 3,5,3?,5?- tetramethylbenzidine, with oxidation capacity of GO increasing with GR content.