Recurrence of Philadelphia chromosome-positive leukemia in donor cells after bone marrow transplantation for chronic granulocytic leukemia

Allogeneic bone marrow transplantation has been shown to be a very effective therapy for Chronic Granulocytic Leukemia with long term disease free survivals in excess of 60%. Relapse rates remain low at 15% following histocompatible sibling transplants and lower rates following matched unrelated donor grafts. Relapse rates however, are higher if BMT is carried out in transformation or blast crisis. Leukemic relapse in donor cells following transplantation for CGL is a rare event. The occurrence of donor leukemia however, may be under reported as accurate and sensitive investigation of the origin of relapsed leukemia following BMT requires DNA based technologies. A possible mechanism of donor leukemia in CGL is transfection of donor cells with the chimeric gene which is unique to this disease. It is possible that the malignant cells found in transformed or blast crisis of CGL may have a greater potential to transfect donor haematopoietic material. Careful evaluation of the incidence of donor leukemia using molecular biology methods may elucidate the frequency of this event following BMT for CGL.

Letter, Lancaster City, PA, to sister, Chesterfield, SC, c. 1800

This letter is from Allie Grafft to her sister.

The Philadelphia String Quartet, January 8, 1971

Concert program for The Philadelphia String Quartet, January 8, 1971

The Philadelphia String Quartet November 19, 1971

Concert program for Philadelphia String Quartet, Nov. 19, 1971

Philadelphia String Quartet October 29, 1971

Concert Program for Philadelphia String Quartet, Oct. 29, 1971

The Philadelphia String Quartet July 13, 1971

Concert program for The Philadelphia String Quartet, July 13, 1971

Produtividade de grãos de cultivares de feijão-caupi, [Vigna unguiculata (L.) Walp], no município de Capitão Poço, PA.

2016