946 resultados para Pericles, approximately 495 B.C.-429 B.C.
Filtro por publicador
- Aberdeen University (1)
- AMS Tesi di Dottorato - Alm@DL - Università di Bologna (1)
- Aquatic Commons (3)
- ARCA - Repositório Institucional da FIOCRUZ (1)
- ArchiMeD - Elektronische Publikationen der Universität Mainz - Alemanha (2)
- Archive of European Integration (34)
- Aston University Research Archive (5)
- Biblioteca Digital | Sistema Integrado de Documentación | UNCuyo - UNCUYO. UNIVERSIDAD NACIONAL DE CUYO. (2)
- Biblioteca Digital da Câmara dos Deputados (2)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (9)
- Biblioteca Digital da Produção Intelectual da Universidade de São Paulo (BDPI/USP) (7)
- Biblioteca Digital de Artesanías de Colombia (1)
- Biblioteca Digital de la Universidad Católica Argentina (1)
- Biblioteca Digital de Teses e Dissertações Eletrônicas da UERJ (1)
- Biblioteca Valenciana Digital - Ministerio de Educación, Cultura y Deporte - Valencia - Espanha (3)
- Bibloteca do Senado Federal do Brasil (5)
- Biodiversity Heritage Library, United States (2)
- BORIS: Bern Open Repository and Information System - Berna - Suiça (23)
- Boston University Digital Common (2)
- Brock University, Canada (5)
- CaltechTHESIS (3)
- Cámara de Comercio de Bogotá, Colombia (1)
- Cambridge University Engineering Department Publications Database (9)
- CentAUR: Central Archive University of Reading - UK (12)
- Center for Jewish History Digital Collections (2)
- Chinese Academy of Sciences Institutional Repositories Grid Portal (17)
- Deakin Research Online - Australia (21)
- DI-fusion - The institutional repository of Université Libre de Bruxelles (1)
- Digital Commons at Florida International University (1)
- Digital Peer Publishing (1)
- DigitalCommons@The Texas Medical Center (8)
- DigitalCommons@University of Nebraska - Lincoln (1)
- Digitale Sammlungen - Goethe-Universität Frankfurt am Main (40)
- Duke University (1)
- eResearch Archive - Queensland Department of Agriculture; Fisheries and Forestry (8)
- Gallica, Bibliotheque Numerique - Bibliothèque nationale de France (French National Library) (BnF), France (50)
- Glasgow Theses Service (1)
- Harvard University (5)
- Helda - Digital Repository of University of Helsinki (16)
- Indian Institute of Science - Bangalore - Índia (113)
- Instituto Nacional de Saúde de Portugal (1)
- Lume - Repositório Digital da Universidade Federal do Rio Grande do Sul (2)
- Martin Luther Universitat Halle Wittenberg, Germany (1)
- Memoria Académica - FaHCE, UNLP - Argentina (9)
- Ministerio de Cultura, Spain (10)
- National Center for Biotechnology Information - NCBI (29)
- Plymouth Marine Science Electronic Archive (PlyMSEA) (2)
- Portal de Revistas Científicas Complutenses - Espanha (2)
- Publishing Network for Geoscientific & Environmental Data (50)
- QUB Research Portal - Research Directory and Institutional Repository for Queen's University Belfast (48)
- Queensland University of Technology - ePrints Archive (59)
- RCAAP - Repositório Científico de Acesso Aberto de Portugal (1)
- Repositório Científico do Instituto Politécnico de Lisboa - Portugal (1)
- Repositório Digital da Universidade Municipal de São Caetano do Sul - USCS (1)
- Repositório Institucional UNESP - Universidade Estadual Paulista "Julio de Mesquita Filho" (49)
- School of Medicine, Washington University, United States (1)
- Universidad Autónoma de Nuevo León, Mexico (2)
- Universidad de Alicante (2)
- Universidad del Rosario, Colombia (3)
- Universidade Complutense de Madrid (2)
- Universidade Federal do Pará (8)
- Universidade Federal do Rio Grande do Norte (UFRN) (3)
- Universidade Metodista de São Paulo (1)
- Université de Lausanne, Switzerland (2)
- Université de Montréal (1)
- Université de Montréal, Canada (2)
- Université Laval Mémoires et thèses électroniques (1)
- University of Michigan (213)
- University of Queensland eSpace - Australia (9)
- University of Southampton, United Kingdom (1)
- University of Washington (9)
Resumo:
A series of 2,5,6-substituted imidazo2,1-b]1,3,4]thiadiazole derivatives have been prepared and were tested for antiproliferative activity on cancer cells at the National Cancer Institute. Results showed that molecules with a benzyl group at position 2, exhibited an increase in activity for the introduction of a formyl group at the 5 position. The compound 2-benzyl-5-formyl-6-(4-bromophenyl)imidazo 2,1-b]1,3,4]thiadiazole 22 has been chosen for understanding the mechanism of action by various molecular and cellular biology studies. Results obtained from cell cycle evaluation analysis, analysis of mitochondrial membrane potential and Annexin V-FITC by flow cytometric analysis, ROS production and expression of apoptotic and DNA-repair proteins suggested that compound 22 induced cytotoxicity by activating extrinsic pathway of apoptosis, however, without affecting cell cycle progression. (C) 2014 Elsevier Ltd. All rights reserved.