Ms. Ff. Mus. 1311 - Am 1. post Epiphan. : Sage mir an, du, den meine Seele liebet, pp. ; C. A. T. B., flauti et oboe, 2 violini, 1 viola, violoncello et organo

von Telemann. [Textverf.: Gottfried Simonis]

Ms. Ff. Mus. 1474 - Feria 1. Pentecostes : [wer mich liebet, der wird mein Wort halten]

Telemann. [Text von Gottfried Simonis]

Ms. Ff. Mus. 1159 - Jubilate

[Georg Philipp Telemann]. [Text: Gottfried Simonis]

Ms. Ff. Mus. 1149 - Am Feste der Himmelfarth Christi : ich fahre auf zu meinem Vatter und zu eurem pp. ; C. A. T. B., 2 corni da caccia, 1 flauto, 2 violini, 2 oboe se piace, 1 viola, violoncello et organo

von Telemann. [Text von Gottfried Simonis]

Ms. Ff. Mus. 883 - Laetare

[Georg Philipp Telemann]. [Text: Gottfried Simonis]

Ms. Ff. Mus. 872 - Am Sonnt. nach Neu=Jahr : der Herr bewahret die Seelen seiner Heiligen ; C. A. T. B., 2 oboe ò flauti traversi, 2 violini, 1 viola, violoncello et organo

von Telemann. [Text: Gottfried Simonis]

Simphonies périodiques à plusieurs instrumens undefined : no. 3

par W. A. Mozart

Ms. Ff. Mus. 994 - V. post Trinit.

da me Telemann

Pinkas der Israelitischen Gemeinde Frankfurt am Main : 1792-1805

Aus dem Bestand des Jüdischen Museums Frankfurt am Main, Inv.nr.: B 1989/018.

Mus Hs 2100,2 - Weihnachten im Schützengraben : [Bühnenmusik zu dem Einakter "Christnacht 1914" von Ludwig Thoma]

[Engelbert Humperdinck]

Mus Hs 678 - Var: Cor, et Fagott ...

par C. Oestreich

Mus Hs 784 - Conzertino für das Second-Horn mit Begleitung: 1nes Fagott's, 2er Clarinetten in A, 1ner Floete, 2er Violinen, Viola, Violoncello und Basso

Karl Oestreich

Mean corpuscular volume as a marker for adherence to antiretroviral therapy among HIV infected children and adolescents in Uganda

Mean corpuscular volume, which is an inexpensive and widely available measure to assess, increases in HIV infected individuals receiving zidovudine and stavudine raising the hypothesis that it could be used as a surrogate for adherence.^ The aim of this study was to examine the association between mean corpuscular volume and adherence to antiretroviral therapy among HIV infected children and adolescents aged 0–19 years in Uganda as well as the extent to which changes in mean corpuscular volume predict adherence as determined by virologic suppression.^ The investigator retrospectively reviewed and analyzed secondary data of 158 HIV infected children and adolescents aged 0–19 years who initiated antiretroviral therapy under an observational cohort at the Baylor College of Medicine Children's Foundation - Uganda. Viral suppression was used as the gold standard for monitoring adherence and defined as viral load of < 400 copies/ml at 24 and 48 weeks. ^ Patients were at least 48 weeks on therapy, age 0.2–18.4 years, 54.4% female, 82.3% on zidovudine based regimen, 92% WHO stage III at initiation of therapy, median pre therapy MCV 80.6 fl (70.3–98.3 fl), median CD4% 10.2% (0.3%–28.0%), and mean pre therapy viral load 407,712.9 ± 270,413.9 copies/ml. For both 24 and 48 weeks of antiretroviral therapy, patients with viral suppression had a greater mean percentage change in mean corpuscular volume (15.1% ± 8.4 vs. 11.1% ± 7.8 and 2.3% ± 13.2 vs. -2.7% ± 10.5 respectively). The mean percentage change in mean corpuscular volume was greater in the first 24 weeks of therapy for patients with and without viral suppression (15.1% ± 8.4 vs. 2.3% ± 13.2 and 11.1% ± 7.8 vs. -2.7% ± 10.5 respectively). In the multivariate logistic regression model, percentage change in mean corpuscular volume ≥ 20% was significantly associated with viral suppression (adjusted OR 4.0; CI 1.2–13.3; p value 0.02). The ability of percentage changes in MCV to correctly identify children and adolescents with viral suppression was higher at a cut off of ≥ 20% (90.7%; sensitivity, 31.7%) than at ≥ 9% (82.9%; sensitivity, 78.9%). Negative predictive value was lower at ≥ 20% change (25%; specificity, 84.8%) than at ≥ 9% change (33.3%; specificity, 39.4%).^ Mean corpuscular volume is a useful marker of adherence among children and adolescents with viral suppression. ^

ROLE OF STAT3 IN KERATINOCYTE STEM CELLS DURING SKIN TUMORIGENESIS

STATs play crucial roles in a wide variety of biological functions, including development, proliferation, differentiation, migration and in cancer development. In the present study, we examined the impact of Stat3 deletion or activation on behavior of keratinocytes, including keratinocyte stem cells (KSCs). Deletion of Stat3 specifically in the bulge region of the hair follicle using K15.CrePR1 X Stat3fl/fl mice led to decreased tumor development by altering survival of bulge region KSCs. To further understand the role of KSCs in skin tumorigenesis, K5.Stat3C transgenic (Tg) mice which express a constitutively active/dimerized form of Stat3 called Stat3C via the bovine keratin 5 (K5) promoter were studied. The number of CD34 and α6 integrin positive cells was significantly reduced in Tg mice as compared to non-transgenic (NTg) littermates. There was a concomitant increase in the progenitor populations (Lgr-6, Lrig-1 and Sca-1) in the Tg mice vs. the stem cell population (CD34 and Keratin15). To investigate the mechanism underlying the increase in the progenitor population at the expense of bulge region KSCs we examined if Stat3C expression was involved in inducing migration of the bulge region KSCs. There was altered β-catenin and α6-integrin expression in the hair follicles of Tg mice, which may have contributed to reduced adhesive interactions between the epithelial cells and the basement membrane facilitating migration out of the niche. To further study the effect of Stat3 on differentiation of keratinocytes we analyzed the epidermal keratinocytes in K5.Cre X Stat3fl/fl mice. There was an increase in the expression of epidermal differentiation markers in the Stat3 knockout mice. These data suggest that deletion of Stat3 in the epidermis and hair follicle induced differentiation in these cells. Preliminary studies done with the BK5.Stat3C mouse model suggests that multiple hair follicle stem/progenitor populations may be involved in skin tumor development and progression in this model of skin tumorigenesis. Overall, these data suggest that Stat3 plays an important role in differentiation as well as migration of keratinocytes and that these effects may play a role during epithelial carcinogenesis.