Data mining the yeast genome in a lazy functional language

Clare, A. and King R.D. (2003) Data mining the yeast genome in a lazy functional language. In Practical Aspects of Declarative Languages (PADL'03) (won Best/Most Practical Paper award).

Taking advantage of an old concept, "illegitimate transcription", for a proposed novel method of genetic diagnosis of McArdle disease

McArdle disease is a metabolic disorder caused by pathogenic mutations in the PYGM gene. Timely diagnosis can sometimes be difficult with direct genomic analysis, which requires additional studies of cDNA from muscle transcripts. Although the "nonsense-mediated mRNA decay" (NMD) eliminates tissue-specific aberrant transcripts, there is some residual transcription of tissue-specific genes in virtually all cells, such as peripheral blood mononuclear cells (PBMCs).We studied a subset of the main types of PYGM mutations (deletions, missense, nonsense, silent, or splicing mutations) in cDNA from easily accessible cells (PBMCs) in 12 McArdle patients.Analysis of cDNA from PBMCs allowed detection of all mutations. Importantly, the effects of mutations with unknown pathogenicity (silent and splicing mutations) were characterized in PBMCs. Because the NMD mechanism does not seem to operate in nonspecific cells, PBMCs were more suitable than muscle biopsies for detecting the pathogenicity of some PYGM mutations, notably the silent mutation c.645G>A (p.K215=), whose effect in the splicing of intron 6 was unnoticed in previous muscle transcriptomic studies.We propose considering the use of PBMCs for detecting mutations that are thought to cause McArdle disease, particularly for studying their actual pathogenicity.

Rural Housing, Affordable Housing and Speaking the Language of an Unaffordable Hearth

Huws, Catrin, 'Rural Housing, Affordable Housing and Speaking the Language of an Unaffordable Hearth', Journal of Planning and Environment Law, (2007) pp.1648-1660 RAE2008

Writing the War on Terrorism: Language, Politics and Counter-terrorism

Jackson, Richard, Writing the War on Terrorism: Language, Politics and Counter-terrorism (Manchester: Manchester University Press, 2005), pp.viii + 232 RAE2008

Language, Policy and the Construction of a Torture Culture in the War on Terrorism

Jackson, R. (2007). Language, Policy and the Construction of a Torture Culture in the War on Terrorism. Review of International Studies. 33(3), pp.353-371 RAE2008

Where the People Are: Language and Community in the Poetry of W.S. Graham

Francis, Matthew, Language and Community in the Poetry of W.S. Graham (Cambridge: Salt Publishing, 2004) RAE2008

Amoral Gower: Language, Sex and Politics

Watt, D. (2003). Amoral Gower: Language, Sex and Politics. Medievil Cultures Series, volume 38. Minneapolis: University of Minnesota Press. RAE2008

The Politics of Language in Romantic Literature

Marggraf Turley, R. (2002). The Politics of Language in Romantic Literature. Basingstoke: Palgrave Macmillan. RAE2008

Old-Irish Verse Fragments Attributed to Fer Muman mac Echtain

Mahon, William, 'Old-Irish Verse Fragments Attributed to Fer Muman mac Echtain', Studi Celtici (2006) 4 pp.223-256 RAE2008

The development of learner autonomy through Internet resources and its impact on English language attainment

Wydział Neofilologii: Instytut Filologii Angielskiej

Between a demonstrative and an article. The status of "in" in Old Swedish

The definite article in the Modern Nordic languages is a suffix, etymologically related to a demonstrative. The form is not attested in runic inscriptions, the oldest linguistic sources, but first appears in Icelandic sagas as well as in Swedish and Danish legal codices from 13th century onwards. However, in these texts it does not appear with the same regularity as in modern languages. The Old Swedish form constitutes an intermediate form between a demonstrative, from which it is derived, and the article it has become in Modern Swedish. In the oldest texts it appears in contexts where demonstratives can only be found sporadically and its form suggests it no longer is a demonstrative. At the same time it is not yet obligatory. The aim of this paper is to show the grammaticalization of the definite article as a gradual, dynamic process, involving changes in the form and functional scope of the grammaticalizing item and to consider the properties of the Old Swedish form -in, derived from the distal demonstrative hin ‘that’.

Edward Sapir’s View About International Auxiliary Language

The search for common attributes of all languages is connected with the search for characteristics which differentiate languages. If some attributes cannot be found in every language, what is cause of this situation? Is it linked up with the origin of language or with users of the language?

Integrative motivation and global language (English) acquisition in Poland

This study investigated the consistency of a measure of integrative motivation in the prediction of achievement in English as a foreign language in 18 samples of Polish school students. The results are shown to have implications for concerns expressed that integrative motivation might not be appropriate to the acquisition of English because it is a global language and moreover that other factors such as the gender of the student or the environment of the class might also influence its predictability. Results of a hierarchical linear modeling analysis indicated that for the older samples, integrative motivation was a consistent predictor of grades in English, unaffected by either the gender of the student or class environment acting as covariates. Comparable results were obtained for the younger samples except that student gender also contributed to the prediction of grades in English. Examination of the correlations of the elements of the integrative motivation score with English grades demonstrated that the aggregate score is the more consistent correlate from sample to sample than the elements themselves. Such results lead to the hypothesis that integrative motivation is a multi-dimensional construct and different aspects of the motivational complex come into play for each individual. That is, two individuals can hold the same level of integrative motivation and thus attain the same level of achievement but one might be higher in some elements and lower in others than another individual, resulting in consistent correlations of the aggregate but less so for the elements.

Gender-dependent language anxiety in Polish communication apprehensives

This paper analyzes the relationship between communication apprehension and language anxiety from the perspective of gender. As virtually no empirical studies have addressed the explicit influence of gender on language anxiety in communication apprehensives, this paper proposes that females are generally more sensitive to anxiety, as reflected in various spheres of communication. For this reason, language anxiety levels in communication apprehensive females should be higher, unlike those of communication apprehensive males. Comparisons between them were made using a student t test, two-way ANOVA, and post-hoc Tukey test. The results revealed that Polish communication apprehensive secondary grammar school males and females do not differ in their levels of language anxiety, although nonapprehensive males experience significantly lower language anxiety than their female peers. It is argued that the finding can be attributed to developmental patterns, gender socialization processes, classroom practices, and the uniqueness of the FL learning process, which is a stereotypically female domain.