Numerical and experimental investigation of structural stiffness influence on ratcheting convection cell in granular soils under cyclic loading

Lateral cyclic loaded structures in granular soils can lead to an accumulation of irreversible strains by changing their mechanical response (densification) and forming a closed convective cell in the upper layer of the bedding. In the present thesis the convective cell dimension, formation and grain migration inside this closed volume have been studied and presented in relation to structural stiffness and different loads. This relation was experimentally investigated by applying a cyclic lateral force to a scaled flexible vertical element embedded in dry granular soil. The model was monitored with a camera in order to derive the displacement field by means of the PIV technique. Modelling large soil deformation turns out to be difficult, using mesh-based methods. Consequently, a mesh-free approach (DEM) was chosen in order to investigate the granular flow with the aim of extracting interesting micromechanical information. In both the numerical and experimental analyses the effect of different loading magnitudes and different dimensions of the vertical element were considered. The main results regarded the different development, shape and dimensions of the convection cell and the surface settlements. Moreover, the Discrete Element Method has proven to give satisfactory results in the modelling of large deformation phenomena such as the ratcheting convective cell.

Immune recovery in HIV-infected patients after candida esophagitis is impaired despite long-term antiretroviral therapy.

OBJECTIVE Candida esophagitis belongs to the most common AIDS-defining diseases, however, a comprehensive immune pathogenic concept is lacking. DESIGN We investigated the immune status of 37 HIV-1-infected patients from the Swiss HIV cohort study at diagnosis of Candida esophagitis, 1 year before, 1 year later and after 2 years of suppressed HIV RNA. We compared these patients to 3 groups: 37 HIV-1-infected patients without Candida esophagitis but similar CD4 counts as the patients at diagnosis (advanced HIV group), 15 HIV-1-infected patients with CD4 counts >500 cells/μl, CD4 nadir >350 cells/μl and suppressed HIV RNA under combination antiretroviral therapy (cART) (early cART group), and 20 healthy individuals. METHODS We investigated phenotype, cytokine production and proliferative capacity of different immune cells by flow cytometry and ELISpot. RESULTS We found that patients with Candida esophagitis had nearly abolished CD4 proliferation in response to C. albicans, significantly increased percentages of dysfunctional CD4 cells, significantly decreased cytotoxic NK-cell counts and peripheral innate lymphoid cells and significantly reduced IFN-γ and IL-17 production compared to the early cART group and healthy individuals. Most of these defects remained for more than 2 years despite viral suppression. The advanced HIV group without opportunistic infection showed partly improved immune recovery. CONCLUSIONS Our data indicate that Candida esophagitis in HIV-1-infected patients is caused by an accumulation of multiple, partly Candida-specific immunological defects. Long-term immune recovery is impaired, illustrating that specific immunological gaps persist despite cART. These data also support the rationale for early cART initiation to prevent irreversible immune defects.

Moderately High Temperatures Inhibit Ribulose-1,5-Bisphosphate Carboxylase/Oxygenase (Rubisco) Activase-Mediated Activation of Rubisco

We tested the hypothesis that light activation of ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) is inhibited by moderately elevated temperature through an effect on Rubisco activase. When cotton (Gossypium hirsutum L.) or wheat (Triticum aestivum L.) leaf tissue was exposed to increasing temperatures in the light, activation of Rubisco was inhibited above 35 and 30°C, respectively, and the relative inhibition was greater for wheat than for cotton. The temperature-induced inhibition of Rubisco activation was fully reversible at temperatures below 40°C. In contrast to activation state, total Rubisco activity was not affected by temperatures as high as 45°C. Nonphotochemical fluorescence quenching increased at temperatures that inhibited Rubisco activation, consistent with inhibition of Calvin cycle activity. Initial and maximal chlorophyll fluorescence were not significantly altered until temperatures exceeded 40°C. Thus, electron transport, as measured by Chl fluorescence, appeared to be more stable to moderately elevated temperatures than Rubisco activation. Western-blot analysis revealed the formation of high-molecular-weight aggregates of activase at temperatures above 40°C for both wheat and cotton when inhibition of Rubisco activation was irreversible. Physical perturbation of other soluble stromal enzymes, including Rubisco, phosphoribulokinase, and glutamine synthetase, was not detected at the elevated temperatures. Our evidence indicates that moderately elevated temperatures inhibit light activation of Rubisco via a direct effect on Rubisco activase.

Long-term Responses of Mountain Ecosystems to Environmental Changes: Resilience, Adjustment, and Vulnerability

The steep environmental gradients of mountain ecosystems over short distances reflect large gradients of several climatic parameters and hence provide excellent possibilities for ecological research on the effects of environmental change. To gain a better understanding of the dynamics of abiotic and biotic parameters of mountain ecosystems, long-term records are required since permanent plots in mountain regions cover in the best case about 50 - 70 years. In order to extend investigations of ecological dynamics beyond these temporal limitations of permanent plots, paleoecological approaches can be used if the sampling resolution can be adapted to ecological research questions, e.g. a sample every 10 years. Paleoecological studies in mountain ecosystems can provide new ecological insights through the combination of different spatial and temporal scales. [f we thus improve our understanding of processes across both steep environmental gradients and different time scales, we may be able to better estimate ecosystem responses to current and future environmental change (Ammann et al. 1993; Lotter et al. 1997). The complexity of ecological interactions in mountain regions forces us to concentrate on a number of sub-systems - without losing sight of the wider context. Here, we summarize a few case studies on the effects of Holocene climate change and disturbance on the vegetation of the Western Alps. To categorize the main response modes of vegetation to climatic change and disturbance in the Alps we use three classes of ecological behaviour: "resilience", "adjustment", and "vulnerability", We assume a resilient (or elastic) behaviour if vegetation is able to recover to its former state, regaining important ecosystem characteristics, such as floristic composition, biodiversity, species abundances, and biomass (e.g. Küttel 1990; Aber and Melillo 199 1). Conversely, vegetation displacements may occur in response to climatic change and/or disturbance. In some cases, this may culminate in irreversible large-scale processes such as species and/or community extinctions. Such drastic developments indicate high ecosystem vulnerability (or inelasticity or instability, for detailed definitions see Küttel 1990; Aber and Melillo 199 1) to climatic change and/or disturbance. In this sense, the "vulnerability" (or instability) of an ecosystem is expressed by the degree of failure to recover to the original state before disturbance and/or climatic change. Between these two extremes (resilience vs. vulnerability), ecosystem adjustments to climatic change and/or disturbance may occur, including the appearance of new and/or the disappearance of old species. The term "adjustment" is hence used to indicate the response of vegetational communities, which adapted to new environmental conditions without losing their main character. For forest ecosystems, we assume vegetational adjustments (rather than vulnerability) if the dominant (or co-dominant) tree species are not outnumbered or replaced by formerly unimportant plant species or new invaders. Adaptation as a genetic process is not discussed here and will require additional pbylogeographical studies (that incorporate the analysis of ancient DNA) in order to fully understand the distributions of ecotypes.

Petrography, chemistry and magnetic properties of ODP Leg 115 basalts

A detailed study of the Fe-Ti oxides in four basalt samples-one from each of the four holes drilled into basement on Ocean Drilling Program Leg 115 (Sites 706, 707, 713, and 715) has been performed. Ilmenite is present only in samples from Sites 706 and 715. In the sample from Site 715, Ti-magnetite intergrowths are characteristic of subaerial (?) high-temperature oxy-exsolution; Ti-magnetite in the other three samples has experienced pervasive low-temperature oxidation to Ti-maghemite, as evidenced by the double-humped, irreversible, saturation magnetization vs. temperature (Js/T) curves. The bulk susceptibility of these samples, which are similar in terms of major element chemistry, varies by a factor of ~20 and correlates semiquantitatively with the modal abundance of Fe-Ti spinel, as determined by image analysis with an electron microprobe. The variation in Fe-Ti oxide abundance correlates with average grain size: fine-grained samples contain less Fe-Ti oxide. This prompts the speculation that the crystallization rate may also influence Fe-Ti oxide abundance.

Meteorological data, stem radius measurements (SR) and derivates of SR of the three Swiss forest sites Visp, Davos and Lägeren

. Separating continuously measured stem radius (SR) fluctuations into growth-induced irreversible stem expansion (GRO) and tree water deficit-induced reversible stem shrinkage (TWD) requires a concept to decide on potential growth processes during periods of shrinking and expanding SR below a precedent maximum. Here we investigated two physiological concepts: the linear growth (LG) concept assuming linear growth vs. the zero growth (ZG) concept assuming no growth during periods of shrunken stems. . We evaluated the physiological mechanisms underlying these two concepts and assessed the respective plausibility with SR data obtained from 15 deciduous and evergreen trees. . The LG concept showed steady growth rates, whereas the ZG concept showed strongly varying growth rates over time, more in accordance with mechanistic expectations. Further, growth increased for maximally 120 min after periods of shrunken stems, indicating limited growth activity during that period. However, the fraction of this extra growth was found to be small. Furthermore, TWD of the ZG concept was better explained by a hydraulic plant model than TWD of the LG concept. . We conclude that periods of shrunken stems allow for very little growth in the four tree species investigated. However, further studies should focus on obtaining independent growth data to ultimately validate these findings.

Variational and Lagrangian thermodynamics of thermal convection-- fundamental shortcomings of the heat-transfer coefficient.

Mode of access: Internet.

Thermodynamics and heat flow analysis by Lagrangian methods.

Mode of access: Internet.

Middle Fork of the Vermilion River, Vermilion County, Illinois : [draft] environmental assessment report /

[1] Description of the proposed action.--[2] Environmental setting without the proposed action.--[3] Impacts of the proposed action. Mitigation built into the proposed action. Adverse impacts of the proposed action. Relationship between local short-term use of man's environment and the maintenance and enhancement of long-term productivity. Any irreversible & irretrievable commitments of resources which would be involved if the proposed action should be implemented. Alternatives to the proposed action.--[4] Glossary, bibliography, appendices.

Middle Fork of the Vermilion River, Vermilion County, Illinois : draft environmental assessment report : preliminary for study purposes only /

Includes bibliography.

International Labour Movement Responses to Globalization /

This book examines international labour movement opposition to globalisation. It chronicles and critically scrutinizes the emergence of distinctively new forms of labour movement organisation and mobilisation that constitute creative initiatives on the part of labour, which present capitalism with fresh challenges.

Entre la universidad y la política. Algunos elementos para investigar las luchas estudiantiles de Corrientes, Rosario, Córdoba y Tucumán entre el golpe de Estado de Onganía y el de Lanusse

Con el golpe de Estado de Onganía en 1966 comenzó un intento de consolidación de un Estado Burocrático Autoritario. El gobierno de facto, cuya base social era el gran capital, impulsó reformas estructurales en la economía y las instituciones tendientes a la despolitización y la concentración del capital. Este proyecto entró en una crisis irreversible en mayo de 1969 con los hechos de masas conocidos como Rosariazo y Cordobazo. La descomposición de la dictadura llegó a su punto crítico tras el Tucumanazo y el Viborazo. Tras estos hechos Lanusse dio un golpe de Estado, promovió el GAN y la convocatoria a elecciones sin proscripciones para 1973. Se considera que a partir de 1969 se inauguró una nueva etapa en las luchas sociales en Argentina expresada en una "nueva izquierda", de agrupaciones revolucionarias armadas, un auge del activismo obrero y estudiantil, etc. Sin embargo, a pesar de que siempre se menciona el rol de los estudiantes del litoral y del interior en el proceso que derrotó a la dictadura, se haya ausente un estudio sistemático de las luchas del movimiento estudiantil de las regiones donde se desarrollaron los mayores enfrentamientos al régimen militar. Aquí presento algunas dimensiones para su investigación

Entre la universidad y la política. Algunos elementos para investigar las luchas estudiantiles de Corrientes, Rosario, Córdoba y Tucumán entre el golpe de Estado de Onganía y el de Lanusse

Con el golpe de Estado de Onganía en 1966 comenzó un intento de consolidación de un Estado Burocrático Autoritario. El gobierno de facto, cuya base social era el gran capital, impulsó reformas estructurales en la economía y las instituciones tendientes a la despolitización y la concentración del capital. Este proyecto entró en una crisis irreversible en mayo de 1969 con los hechos de masas conocidos como Rosariazo y Cordobazo. La descomposición de la dictadura llegó a su punto crítico tras el Tucumanazo y el Viborazo. Tras estos hechos Lanusse dio un golpe de Estado, promovió el GAN y la convocatoria a elecciones sin proscripciones para 1973. Se considera que a partir de 1969 se inauguró una nueva etapa en las luchas sociales en Argentina expresada en una "nueva izquierda", de agrupaciones revolucionarias armadas, un auge del activismo obrero y estudiantil, etc. Sin embargo, a pesar de que siempre se menciona el rol de los estudiantes del litoral y del interior en el proceso que derrotó a la dictadura, se haya ausente un estudio sistemático de las luchas del movimiento estudiantil de las regiones donde se desarrollaron los mayores enfrentamientos al régimen militar. Aquí presento algunas dimensiones para su investigación

Glutathione in Parkinson's disease

Thesis (Ph.D.)--University of Washington, 2016-03

Defining Atoh1 function and regulation in avian supporting cells during auditory hair cell regeneration

Thesis (Ph.D.)--University of Washington, 2016-06