University of Utah J. Willard Marriott Library Addition, Salt Lake City, 1992-1996

[Conceptual Sketches], untitled. Ink sketches with marker coloring on tracing paper, 18 x 28 1/2 inches [from photographic copy by Lance Burgharrdt]

University of Utah J. Willard Marriott Library Addition, Salt Lake City, 1992-1996

[Conceptual Sketches], untitled. Ink sketches with marker coloring on tracing paper, initialed, 12 x 28 1/2 inches [from photographic copy by Lance Burgharrdt]

Juma al-Majid Center for Culture and Heritage Competition, Dubai, United Arab Emirates, 1993 (unbuilt project)

[Schematic Design Drawing of] East Elevation. Black and colored ink and pencil drawing with marker coloring on two blue-line prints, 9 1/4 x 38 & 9 1/2 x 41 1/2 inches [from photographic copy by Lance Burgharrdt]

Juma al-Majid Center for Culture and Heritage Competition, Dubai, United Arab Emirates, 1993 (unbuilt project)

[Conceptual Sketch], untitled. Ink sketch with marker coloring on tracing paper, 18 x 37 1/2 inches [from photographic copy by Lance Burgharrdt]

Juma al-Majid Center for Culture and Heritage Competition, Dubai, United Arab Emirates, 1993 (unbuilt project)

[Conceptual Sketch], untitled. Blue pencil sketch on tracing paper, 18 x 37 1/2 inches [from photographic copy by Lance Burgharrdt]

Plot plan

Blueprint; reduced sketch of property in FLO2, with outline of residence, buildings, driveway, locations of trees and topo lines; in pencil at lower right, "Florsheim"; unsigned. 73 x 52 cm. Scale: 1/2" = 1' [from photographic copy by Lance Burgharrdt]

Catalogue of the library of the Society of writers to the Signet. In four parts, with a general index.

Pt. 1-4, and "Rules and regulations for the library" have each special t.-p. and separate paging; general t.-p. issued with index, 1837. Pt. 1-4 have title: Catalogue of the library of the Writers to His Majesty's Signet.

The religious philosopher, or, The right use of contemplating the works of the Creator : I. In the wonderful structure of animal bodies, and ... man, II. In the ... formation of the elements, and their various effects upon animal and vegetable bodies, and, III. In the ... structure of the heavens, with all its furniture : designed for the conviction of atheists and infidels /

Vol. 1 includes table of contents for v. 2, varying from that in v. 2.

Catalog of the library,

A classified catalog with alphabetical subject index.

Botanical expeditions. Col. J.C. Frémont. Col. W.H. Emory. Howard Stansbury. Jno. Torrey. 1843-8.

[No. 1] is extracted from J.C. Frémont. Report of exploring expedition to the Rocky Mountains in the year 1842; [no. 2-3] from U.S. Engineer dept. Notes of a military reconnoissance from Fort Leavenworth, in Missouri, to San Diego, in California ... By Lieut. Col. W.H. Emory; [no. 4] from U.S. Engineer dept. Exploration and survey of the valley of the Great Salt Lake in Utah.

Queering U.S. History Museums: Heteronormative Histories, Digital Disruptions

Thesis (Ph.D.)--University of Washington, 2016-06

Cosegregation analysis of natriuretic peptide genes and blood pressure in the spontaneously hypertensive rat

1. The natriuretic peptide precursor A (Nppa) and B (Nppb) genes are candidate genes for hypertension and cardiac hypertrophy in the spontaneously hypertensive rat (SHR). The purpose of the present study was to determine the role of the Nppa and Nppb genes in the development of hypertension in the SHR. 2. A cohort (n = 162) of F2 segregating intercross animals was established between strains of hypertensive SHR and normotensive Wistar-Kyoto rats. Blood pressure and heart weight were measured in each rat at 12-16 weeks of age. Rats were genotyped using 11 informative microsatellite markers, distributed in the vicinity of the Nppa marker on rat chromosome 5 including an Nppb marker. The phenotype values were compared with genotype using the computer package MAP-MAKER 3.0 (Whitehead Institute, Boston, MA, USA) to determine whether there was a link between the genetic variants of the natriuretic peptide family and blood pressure or cardiac hypertrophy. 3. A strong correlation was observed between the Nppa marker and blood pressure. A quantitative trait locus (QTL) for blood pressure on chromosome 5 was identified between the Nppa locus and the D5Mgh15 marker, less than 2 cM from the Nppa locus. The linkage score for the blood pressure QTL on chromosome 5 was 3.8 and the QTL accounted for 43% of the total variance of systolic blood pressure, 54% of diastolic blood pressure and 59% of mean blood pressure. No association was found between the Nppb gene and blood pressure. This is the first report of linkage between the Nppa marker and blood pressure in the rat. There was no correlation between the Nppa or Nppb genes or other markers in this region and either heart weight or left ventricular weight in F2 rats. 4. These findings suggest the existence of a blood pressure-dependent Nppa marker variant or a gene close to Nppa predisposing to spontaneous hypertension in the rat. It provides a strong foundation for further detailed genetic studies in congenic strains, which may help to narrow down the location of this gene and lead to positional cloning.

Sexual abuse and suicidality: gender differences in a large community sample of adolescents

Objective: A cross-sectional study of gender specific relationships between self-reported child sexual abuse and suicidality in a community sample of adolescents. Method: Students aged 14 years on average (N = 2,485) from 27 schools in South Australia completed a questionnaire including items on sexual abuse and suicidality, and measures of depression (Centre for Epidemiological Studies Depression Scale), hopelessness (Beck Hopelessness Scale), and family functioning (McMaster Family Assessment Device General Functioning Subscale). Data analysis included logistic regression. Results: In boys, self-report sexual abuse is strongly and independently associated with suicidal thoughts, plans, threats, deliberate self-injury, and suicide attempts, after controlling for current levels of depression, hopelessness, and family dysfunction. In girls, the relationship between sexual abuse and suicidality is mediated fully by depression, hopelessness, and family dysfunction. Girls who report current high distress about sexual abuse, however, have a threefold increased risk of suicidal thoughts and plans, compared to non-abused girls. Boys who report current high distress about sexual abuse have 10-fold increased risk for suicidal plans and threats, and 15-fold increased risk for suicide attempts, compared to non-abused boys. Fifty-five percent (n = 15) of sexually abused boys attempted suicide versus 29% (n = 17) girls. Conclusions: A history of sexual abuse should alert clinicians, professionals and caters in contact with adolescents, to greatly increased risks of suicidal behavior and attempts in boys, even in the absence of depression and hopelessness. Distress following sexual abuse, along with depression and hopelessness indicate increased risk of suicidal behavior in girls, as well as boys. (C) 2004 Published by Elsevier Ltd.

Automatic message handling for a national counselling service

An automatic email handling system (AutoRouter) was introduced at a national counselling service in Australia. In 2003, counsellors responded to a total of 7421 email messages. Over nine days in early May 2004 the administrator responsible for the management of the manual email counselling service recorded the time spent on managing email messages. The AutoRouter was then introduced. Since the implementation of the AutoRouter the administrator's management role has become redundant, an average of 12 h 5 min per week of staff time has been saved. There have been further savings in supervisor time. Counsellors were taking an average of 6.2 days to respond to email messages (n=4307), with an average delay of 1.2 days from the time counsellors wrote the email to when the email was sent. Thus the response was sent on average 7.4 days after receipt of the original client email message. A significant decrease in response time has been noted since implementation of the AutoRouter, with client responses now taking an average of 5.4 days, a decrease of 2.0 days. Automatic message handling appears to be a promising method of managing the administration of a steadily increasing email counselling service.

Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking

Insulin stimulates the translocation of the glucose transporter GLUT4 from intracellular vesicles to the plasma membrane. In the present study we have conducted a comprehensive proteomic analysis of affinity-purified GLUT4 vesicles from 3T3-L1 adipocytes to discover potential regulators of GLUT4 trafficking. In addition to previously identified components of GLUT4 storage vesicles including the insulin-regulated aminopeptidase insulin-regulated aminopeptidase and the vesicle soluble N-ethylmaleimide factor attachment protein (v-SNARE) VAMP2, we have identified three new Rab proteins, Rab10, Rab11, and Rab14, on GLUT4 vesicles. We have also found that the putative Rab GTPase-activating protein AS160 (Akt substrate of 160 kDa) is associated with GLUT4 vesicles in the basal state and dissociates in response to insulin. This association is likely to be mediated by the cytosolic tail of insulin-regulated aminopeptidase, which interacted both in vitro and in vivo with AS160. Consistent with an inhibitory role of AS160 in the basal state, reduced expression of AS160 in adipocytes using short hairpin RNA increased plasma membrane levels of GLUT4 in an insulin-independent manner. These findings support an important role for AS160 in the insulin regulated trafficking of GLUT4.