Girl Connection, August 2004

Bimonthly newsletter of the Iowa Gender-Specific Services Task Force. This issue discusses girls and the impact of involvement in sports and other physical activities.

Iowa Community Empowerment Newsletter, October 2002, Vol. 3, no. 5

Monthly newsletter for the Iowa Department of Public Health

Le Catalogue des livres examinez et censurez par la faculté de théologie de l'université de Paris, depuis l'an mil cinq cens quarante et quatre jusques à l'an mil cinq cens cinquante et un... auquel sont adjoustez ceulx qui ont esté visitez et censurez depuis la première impression

[Acte. 1544-1551]

Knowledge management for systems biology a general and visually driven framework applied to translational medicine

Background: To enhance our understanding of complex biological systems like diseases we need to put all of the available data into context and use this to detect relations, pattern and rules which allow predictive hypotheses to be defined. Life science has become a data rich science with information about the behaviour of millions of entities like genes, chemical compounds, diseases, cell types and organs, which are organised in many different databases and/or spread throughout the literature. Existing knowledge such as genotype - phenotype relations or signal transduction pathways must be semantically integrated and dynamically organised into structured networks that are connected with clinical and experimental data. Different approaches to this challenge exist but so far none has proven entirely satisfactory. Results: To address this challenge we previously developed a generic knowledge management framework, BioXM™, which allows the dynamic, graphic generation of domain specific knowledge representation models based on specific objects and their relations supporting annotations and ontologies. Here we demonstrate the utility of BioXM for knowledge management in systems biology as part of the EU FP6 BioBridge project on translational approaches to chronic diseases. From clinical and experimental data, text-mining results and public databases we generate a chronic obstructive pulmonary disease (COPD) knowledge base and demonstrate its use by mining specific molecular networks together with integrated clinical and experimental data. Conclusions: We generate the first semantically integrated COPD specific public knowledge base and find that for the integration of clinical and experimental data with pre-existing knowledge the configuration based set-up enabled by BioXM reduced implementation time and effort for the knowledge base compared to similar systems implemented as classical software development projects. The knowledgebase enables the retrieval of sub-networks including protein-protein interaction, pathway, gene - disease and gene - compound data which are used for subsequent data analysis, modelling and simulation. Pre-structured queries and reports enhance usability; establishing their use in everyday clinical settings requires further simplification with a browser based interface which is currently under development.

From Support to Control : A Configurational Perspective on Conjugal Quality

The topic of conjugal quality provides an empirical illustration of the relevance of the configurational perspective on families. Based on a longitudinal sample of 1,534 couples living in Switzerland drawn from the study "Social Stratification, Cohesion and Conflict in Contemporary Families", we show that various types of interdependencies with relatives and friends promote distinct conflict management strategies for couples as well as unequal levels of conjugal quality. We find that configurations characterized by supportive and non-interfering relationships with relatives and friends for both partners are associated with higher conjugal quality, while configurations characterized by interference are associated with lower conjugal quality.

Responsabilidade no cuidar: do tempo que nos toca viver como enfermeiros/as intensivistas

Investigação qualitativa, balizada na analítica foucaultiana, com ênfase na noção de governabilidade, constituiu como objetivos: analisar a articulação da tecnobiomedicina e bioética, como discursos da contemporaneidade implicados na produção da subjetividade do/a enfermeiro/a no contexto da Unidade de Terapia Intensiva (UTI); e abordar a responsabilidade no cuidar como um dos desdobramentos estratégicos e tecnológicos de diferentes discursos, gerando determinados modos de conceber e intervir do sujeito enfermeiro/a na UTI. Nessa perspectiva, dos múltiplos vieses que poderiam emergir ao se fazer uma leitura crítica dos textos analisados e das entrevistas com os/as enfermeiros/as, a temática da responsabilidade do cuidar foi desdobrada em categorias que expressaram a responsabilidade diante das novas linguagens e da enfermagem como guardiã de certos atributos da UTI.