Comparison of ASAS improvement criteria for ankylosing spondylitis with clinically relevant improvement according to an expert panel

Objective: To investigate whether the recently developed (statistically derived) "ASsessment in Ankylosing Spondylitis Working Group" improvement criteria (ASAS-IC) for ankylosing spondylitis (AS) reflect clinically relevant improvement according to the opinion of an expert panel. Methods: The ASAS-IC consist of four domains: physical function, spinal pain, patient global assessment, and inflammation. Scores on these four domains of 55 patients with AS, who had participated in a non-steroidal anti-inflammatory drug efficacy trial, were presented to an international expert panel (consisting of patients with AS and members of the ASAS Working Group) in a three round Delphi exercise. The number of (non-) responders according to the ASAS-IC was compared with the final-consensus of the experts. The most important domains in the opinion of the experts were identified, and also selected with discriminant analysis. A number of provisional criteria sets that best represented the consensus of the experts were defined. Using other datasets, these clinically derived criteria sets as well as the statistically derived ASAS-IC were then tested for discriminative properties and for agreement with the end of trial efficacy by patient and doctor. Results: Forty experts completed the three Delphi rounds. The experts considered twice as many patients to be responders than the ASAS-IC (42 v 21). Overall agreement between experts and ASAS-IC was 62%. Spinal pain was considered the most important domain by most experts and was also selected as such by discriminant analysis. Provisional criteria sets with an agreement of greater than or equal to 80% compared with the consensus of the experts showed high placebo response rates (27-42%), in contrast with the ASAS-IC with a predefined placebo response rate of 25%. All criteria sets and the ASAS-IC discriminated well between active and placebo treatment (chi(2) = 36-45; p < 0.001). Compared with the end of trial efficacy assessment, the provisional criteria sets showed an agreement of 71-82%, sensitivity of 67-83%, and specificity of 81-88%. The ASAS-IC showed an agreement of 70%, sensitivity of 62%, and specificity of 89%. Conclusion: The ASAS-IC are strict in defining response, are highly specific, and consequently show lower sensitivity than the clinically derived criteria sets. However, those patients who are considered as responders by applying the ASAS-IC are acknowledged as such by the expert panel as well as by. patients' and doctors' judgments, and are therefore likely to be true responders.

Do β-amyloid (Aβ) deposits in patients with Alzheimer's disease and Down's syndrome grow according to the log-normal model?

The size frequency distributions of diffuse, primitive and classic β- amyloid (Aβ) deposits were studied in single sections of cortical tissue from patients with Alzheimer's disease (AD) and Down's syndrome (DS) and compared with those predicted by the log-normal model. In a sample of brain regions, these size distributions were compared with those obtained by serial reconstruction through the tissue and the data used to adjust the size distributions obtained in single sections. The adjusted size distributions of the diffuse, primitive and classic deposits deviated significantly from a log-normal model in AD and DS, the greatest deviations from the model being observed in AD. More Aβ deposits were observed close to the mean and fewer in the larger size classes than predicted by the model. Hence, the growth of Aβ deposits in AD and DS does not strictly follow the log-normal model, deposits growing to within a more restricted size range than predicted. However, Aβ deposits grow to a larger size in DS compared with AD which may reflect differences in the mechanism of Aβ formation.

Size distribution curves of senile plaques in patients with Alzheimer’s disease: do plaques grow according to the log-normal model?

The size frequency distributions of diffuse, primitive and cored senile plaques (SP) were studied in single sections of the temporal lobe from 10 patients with Alzheimer’s disease (AD). The size distribution curves were unimodal and positively skewed. The size distribution curve of the diffuse plaques was shifted towards larger plaques while those of the neuritic and cored plaques were shifted towards smaller plaques. The neuritic/diffuse plaque ratio was maximal in the 11 – 30 micron size class and the cored/ diffuse plaque ratio in the 21 – 30 micron size class. The size distribution curves of the three types of plaque deviated significantly from a log-normal distribution. Distributions expressed on a logarithmic scale were ‘leptokurtic’, i.e. with excess of observations near the mean. These results suggest that SP in AD grow to within a more restricted size range than predicted from a log-normal model. In addition, there appear to be differences in the patterns of growth of diffuse, primitive and cored plaques. If neuritic and cored plaques develop from earlier diffuse plaques, then smaller diffuse plaques are more likely to be converted to mature plaques.

[Review of] Ivo Mijnssen, The Quest for an Ideal Youth in Putin’s Russia I. Back to Our Future! History, Modernity and Patriotism According to Nashi, 2005–2012. Soviet and Post-Soviet Politics and Society, Stuttgart: Ibidem Verlag, 2012, 202pp., e 34.90 p/b

THE YOUTH MOVEMENT NASHI (OURS) WAS FOUNDED IN THE SPRING of 2005 against the backdrop of Ukraine’s ‘Orange Revolution’. Its aim was to stabilise Russia’s political system and take back the streets from opposition demonstrators. Personally loyal to Putin and taking its ideological orientation from Surkov’s concept of ‘sovereign democracy’, Nashi has sought to turn the tide on ‘defeatism’ and develop Russian youth into a patriotic new elite that ‘believes in the future of Russia’ (p. 15). Combining a wealth of empirical detail and the application of insights from discourse theory, Ivo Mijnssen analyses the organisation’s development between 2005 and 2012. His analysis focuses on three key moments—the organisation’s foundation, the apogee of its mobilisation around the Bronze Soldier dispute with Estonia, and the 2010 Seliger youth camp—to help understand Nashi’s organisation, purpose and ideational outlook as well as the limitations and challenges it faces. As such,the book is insightful both for those with an interest in post-Soviet Russian youth culture, and for scholars seeking a rounded understanding of the Kremlin’s initiatives to return a sense of identity and purpose to Russian national life.The first chapter, ‘Background and Context’, outlines the conceptual toolkit provided by Ernesto Laclau and Chantal Mouffe to help make sense of developments on the terrain of identity politics. In their terms, since the collapse of the Soviet Union, Russia has experienced acute dislocation of its identity. With the tangible loss of great power status, Russian realities have become unfixed from a discourse enabling national life to be constructed, albeit inherently contingently, as meaningful. The lack of a Gramscian hegemonic discourse to provide a unifying national idea was securitised as an existential threat demanding special measures. Accordingly, the identification of those who are ‘notUs’ has been a recurrent theme of Nashi’s discourse and activity. With the victory in World War II held up as a foundational moment, a constitutive other is found in the notion of ‘unusual fascists’. This notion includes not just neo-Nazis, but reflects a chain of equivalence that expands to include a range of perceived enemies of Putin’s consolidation project such as oligarchs and pro-Western liberals.The empirical background is provided by the second chapter, ‘Russia’s Youth, the Orange Revolution, and Nashi’, which traces the emergence of Nashi amid the climate of political instability of 2004 and 2005. A particularly note-worthy aspect of Mijnssen’s work is the inclusion of citations from his interviews with Nashicommissars; the youth movement’s cadres. Although relatively few in number, such insider conversations provide insight into the ethos of Nashi’s organisation and the outlook of those who have pledged their involvement. Besides the discussion of Nashi’s manifesto, the reader thus gains insight into the motivations of some participants and behind-the-scenes details of Nashi’s activities in response to the perceived threat of anti-government protests. The third chapter, ‘Nashi’s Bronze Soldier’, charts Nashi’s role in elevating the removal of a World War II monument from downtown Tallinn into an international dispute over the interpretation of history. The events subsequent to this securitisation of memory are charted in detail, concluding that Nashi’s activities were ultimately unsuccessful as their demands received little official support.The fourth chapter, ‘Seliger: The Foundry of Modernisation’, presents a distinctive feature of Mijnssen’s study, namely his ethnographic account as a participant observer in the Youth International Forum at Seliger. In the early years of the camp (2005–2007), Russian participants received extensive training, including master classes in ‘methods of forestalling mass unrest��� (p. 131), and the camp served to foster a sense of group identity and purpose among activists. After 2009 the event was no longer officially run as a Nashi camp, and its role became that of a forum for the exchange of ideas about innovation, although camp spirit remained a central feature. In 2010 the camp welcomed international attendees for the first time. As one of about 700 international participants in that year the author provides a fascinating account based on fieldwork diaries.Despite the polemical nature of the topic, Mijnssen’s analysis remains even-handed, exemplified in his balanced assessment of the Seliger experience. While he details the frustrations and disappointments of the international participants with regard to the unaccustomed strict camp discipline, organisational and communication failures, and the controlled format of many discussions,he does not neglect to note the camp’s successes in generating a gratifying collective dynamic between the participants, even among the international attendees who spent only a week there.In addition to the useful bibliography, the book is back-ended by two appendices, which provide the reader with important Russian-language primary source materials. The first is Nashi’s ‘Unusual Fascism’ (Neobyknovennyi fashizm) brochure, and the second is the booklet entitled ‘Some Uncomfortable Questions to the Russian Authorities’ (Neskol’ko neudobnykh voprosov rossiiskoivlasti) which was provided to the Seliger 2010 instructors to guide them in responding to probing questions from foreign participants. Given that these are not readily publicly available even now, they constitute a useful resource from the historical perspective.

Az egyetemi hallgatók véleménye a kommunikációs készség fejlesztésének fontosságáról = Importance of communication skills according to bachelor and master students

Kutatásomban arra a kérdésre kerestem a választ, hogy a Budapesti Corvinus Egyetemen a hallgatók miként vélekednek a képességek, készségek fejlesztésének fontosságáról az egyetemi képzésen belül. Ennek érdekében 2015 februárjában kérdőíves felmérést végeztem 106 hallgató megkérdezésével. A hallgatók 90%-a egyetértett azzal az állítással, hogy a szakmai ismeretek átadása mellett a képességek, készségek fejlesztésére is hangsúlyt kell helyezni az egyetemi oktatásban. A jövőbeli sikerességük szempontjából a három legfontosabbnak tartott képességek: a problémamegoldó képesség, a gondolkodási képesség és a jó kommunikációs készség. A hallgatók tisztába vannak a jó kommunikációs készség fontosságával az élet számos területén, viszont szembe kell nézni az egyetemi oktatás korlátozott lehetőségeivel. Az oktatók gyakran kényszerülnek választás elé, mire helyezzék az oktatásba elsődlegesen a hangsúlyt, milyen módszertant alkalmazzanak. Ezt a döntést segíti, ha ismerjük hallgatóink preferenciáit, céljait, viszonyukat az egyes módszertani eszközökhöz. Jelen tanulmány ebben kíván segítséget nyújtani. _______ The purpose of this study was to investigate students’ opinion about the importance of skills and abilities development within university. In February 2015 a survey was conducted by interviewing 106 students. More than 90% of students agreed with the statement that beside professional skill transfer, skills and abilities development should be emphasized as well. According to students’ opinion the three most important skills for their future success are: problem-solving, creative thinking and communication skills. Students are aware of the importance of good communication skills in many areas of life but the opportunity of its development is restricted. Lecturers are often forced to make a choice about teaching goals, priorities and teaching methods. Knowledge about students’ goals, preferences and feelings about teaching methods supports this decision. This study intends to provide assistance in this.

Munkavállalói preferenciák az egyetemi hallgatók körében = Employees' preferences according to graduates and undergraduates

Napjaink munkaerőpiaci tendenciái következtében egyre több figyelem irányul az atipikus munkavégzésre. Az atipikus munkavégzésben rejlő lehetőségeket a munkavállalók oldaláról vizsgáltuk. Ennek érdekében egy kétfázisú kutatássorozatot hajtottuk végre a Budapesti Corvinus Egyetem hallgatói körében. A felmérés rámutatott arra, hogy az egyetemi hallgatók már az egyetemi tanulmányaik alatt is potenciális munkaerőt jelentenek. Foglalkoztatásuk során a legfontosabb tényező a rugalmas, tanulmányokkal összeegyeztethető munkavégzés. A második kutatás fő célja a teljes életcikluson keresztüli munkavállalói preferenciák feltárása volt. A hallgatók által a két leginkább előnybe részesített munkavállalási forma a napi nyolcórás munkaviszony rugalmas munkaidőben és a saját vállalkozás indítása. A hallgatók elsősorban magas jövedelmet, ezt követően stabil, biztos jövedelmet, fejlődési lehetőséget, és a munka és magánélet egyensúlyát várják el munkahelyüktől. A tanulmány rámutat az egyes alcsoportok különbségeire, illetve kiindulópontot jelenthet további kutatásokhoz. _____ More and more attention is paid to atypical work due to workplace trends. Increasing opportunities deriving from atypical work have been investigated from employees’ viewpoint in this paper. We conducted a two-step survey amongst graduates and undergraduates of Corvinus University of Budapest. The survey pointed out that undergraduates are potential workers as well, and the most important factor for them was the flexible form of work. The second survey aimed to explore employees’ preferences through a whole lifetime period. The two most popular forms of work were flexible full-time jobs and starting their own enterprise. Students prefer high salaries, a stable and secure income, opportunities for development and work-life balance. The surveys pointed out some differences between subgroups and their conclusions could be a starting point for future research.

(Table S1) Diatom abundance according to ice cycles in ANDRILL AND1-1B drill core

The influence of Antarctica and the Southern Ocean on Late Pliocene global climate reconstructions has remained ambiguous due to a lack of well-dated Antarctic-proximal, paleoenvironmental records. Here we present ice sheet, sea-surface temperature, and sea ice reconstructions from the ANDRILL AND-1B sediment core recovered from beneath the Ross Ice Shelf. We provide evidence for a major expansion of an ice sheet in the Ross Sea that began at ~3.3 Ma, followed by a coastal sea surface temperature cooling of ~2.5°C, a stepwise expansion of sea ice, and polynya-style deep mixing in the Ross Sea between 3.3 and 2.5 Ma. The intensification of Antarctic cooling resulted in strengthened westerly winds and invigorated ocean circulation. The associated northward migration of Southern Ocean fronts has been linked with reduced Atlantic Meridional Overturning Circulation by restricting surface water connectivity between the ocean basins, with implications for heat transport to the high latitudes of the North Atlantic. While our results do not exclude low-latitude mechanisms as drivers for Pliocene cooling, they indicate an additional role played by southern high-latitude cooling during development of the bipolar world.

Berry size and seed number of V. myrtillus and E. hermaphroditum according to treatment, and environmental parameters 1991-2009 at Abisko Research Station

This study investigated the effects of long-term-enhanced UV-B, and combined UV-B with elevated CO2 on dwarf shrub berry characteristics in a sub-arctic heath community. Germination of Vaccinium myrtillus was enhanced in seeds produced at elevated UV-B, but seed numbers and berry size were unaffected. Elevated UV-B and CO2 stimulated the abundance of V. myrtillus berries, whilst UV-B alone stimulated the berry abundance of V. vitis-idaea and Empetrum hermaphroditum. Enhanced UV-B reduced concentrations of several polyphenolics in V. myrtillus berries, whilst elevated CO2 increased quercetin glycosides in V. myrtillus, and syringetin glycosides and anthocyanins in E. hermaphroditum berries. UV-B x CO2 interactions were found for total anthocyanins, delphinidin-3-hexoside and peonidin-3-pentosidein in V. myrtillus berries but not E. hermaphroditum. Results suggest positive impacts of UV-B on the germination of V. myrtillus and species-specific impacts of UV-B x elevated CO2 on berry abundance and quality. The findings have relevance and implications for human and animal consumers plus seed dispersal and seedling establishment.

Comparison of excess radiological risk of building materials and industrial by-products according to I-index (EU-BSS) and revised room model (IAEA SSG-32)

To get a better insight into the radiological features of industrial by-products that can be reused in building materials a review of the reported scientific data can be very useful. The current study is based on the continuously growing database of the By-BM (H2020-MSCA-IF-2015) project (By-products for Building Materials). Currently, the By-BM database contains individual data of about 431 by-products and 1095 building and raw materials. It was found that in case of the building materials the natural radionuclide content varied widely (Ra-226: <DL-27851 Bq/kg; Th-232: <DL-906 Bq/kg, K-40: <DL-17922 Bq/kg), more so than for the by-products (Ra-226: 7-3152 Bq/kg; Th-232: <DL-1350 Bq/kg, K-40: <DL-3001 Bq/kg). The average Ra-226, Th-232 and K-40 contents of the reported by-products were respectively 2.52, 2.35 and 0.39 times higher than the building materials. The gamma exposure of bulk building products was calculated according to IAEA Specific Safety Guide No. SSG-32 and the European Commission Radiation Protection 112 based I-index (EU BSS). It was found that in most cases the I-index without density consideration provides a significant overestimation in excess effective dose.

Neural networks would 'vote' according to Borda's Rule

Can neural networks learn to select an alternative based on a systematic aggregation of convicting individual preferences (i.e. a 'voting rule')? And if so, which voting rule best describes their behavior? We show that a prominent neural network can be trained to respect two fundamental principles of voting theory, the unanimity principle and the Pareto property. Building on this positive result, we train the neural network on profiles of ballots possessing a Condorcet winner, a unique Borda winner, and a unique plurality winner, respectively. We investigate which social outcome the trained neural network chooses, and find that among a number of popular voting rules its behavior mimics most closely the Borda rule. Indeed, the neural network chooses the Borda winner most often, no matter on which voting rule it was trained. Neural networks thus seem to give a surprisingly clear-cut answer to one of the most fundamental and controversial problems in voting theory: the determination of the most salient election method.

Comparison of the hatching success between translocated nests and “in situ” nests according to the type of substrate and the floods due to the tide.

[EN] A new nesting colony of Caretta caretta has recently been discovered and described in Boavista (Cabo Verde, Western Africa, FIGURE 1). Although more data are needed, it represents one of the most important populations in the North Atlantic (Brongersma, 1982; ; Ross, 1995; López-Jurado & Andreu, 1998). A tagging and management campaign has been established in Boavista to study this nesting population since 1998.

St. Louis to St. Paul Corridor Feasibility and Necessity Study: Consultant's Report to the States, 1990

The study analyzes the need for a four-lane highway between St. Louis and St. Paul, and finds it to be needed; it analyzes the highway's feasibility, and finds it to be feasible; it analyzes alternative design standards and suggests that it be built to expressway standards; and, the study evaluates alternative routes and presents four "finalist" routes for your consideration.

St. Louis to St. Paul Corridor Feasibility and Necessity Study: Consultant's Summary Report, 1990

The study analyzes the need for a four-lane highway between St. Louis and St. Paul, and finds it to be needed; it analyzes the highway's feasibility, and finds it to be feasible; it analyzes alternative design standards and suggests that it be built to expressway standards; and, the study evaluates alternative routes and presents four "finalist" routes for your consideration.

Analysis of a socio-professional group underestimated: officials of notaries in Southern Spain according to the cadastre of Ensenada.

This paper tries to show the reality of one of the trades more important for historians, the officials of the notaries. The work of these officials has allowed us to have great historical sources; we refer to the notarial documentation and documenta-tion of the City Council. They were the executive arm of the pub-lic notaries. Nevertheless, the approach to this figure seems diffi-cult, since we do not find lavish allusions of them or any of their obligations in the documentation preserved. However, we have one of the most important historical sources by middle of Eight-eenth century; this is known as the Cadastre of Ensenada. We have been able to approach this type of job through analysis and study of the Cadastre, so we know who were those men who did this huge undertaking and what was his salary for performing their tasks. In addition, we proceeded to the consultation of doc-umentation kept in local files to have a more accurate understand-ing of the real situation of those officials.