Developing new radiotherapy techniques using linac based gamma radiation sources

A major challenge in cancer radiotherapy is to deliver a lethal dose of radiation to the target volume while minimizing damage to the surrounding normal tissue. We have proposed a model on how treatment efficacy might be improved by interfering with biological responses to DNA damage using exogenous electric fields as a strategy to drastically reduce radiation doses in cancer therapy. This approach is demonstrated at this Laboratory through case studies with prokaryotes (bacteria) and eukaryotes (yeast) cells, in which cellkilling rates induced by both gamma radiation and exogenous electric fields were measured. It was found that when cells exposed to gamma radiation are immediately submitted to a weak electric field, cell death increases more than an order of magnitude compared to the effect of radiation alone. This finding suggests, although does not prove, that DNA damage sites are reached and recognized by means of long-range electric DNA-protein interaction, and that exogenous electric fields could destructively interfere with this process. As a consequence, DNA repair is avoided leading to massive cell death. Here we are proposing the use this new technique for the design and construction of novel radiotherapy facilities associated with linac generated gamma beams under controlled conditions of dose and beam intensity.

A Influência da Referência de Tensão na Avaliação de Indicadores de Qualidade de Energia

This paper discusses the importance of the voltage referential for power quality monitoring and power systempsilas instrumentation. Considering the operating conditions of simple power circuits, it will be demonstrated that an incorrect choice of the voltages referential may result in erroneous quantification of some power quality indices, especially in three-phase four wire circuits. The use of a virtual reference point and the neutral conductor as reference have been considered and the simulation results confirm the influence of the voltage reference selection in the evaluation of total harmonic distortion, unbalance factors and voltage sags. Finally a way of linking both methods will be discussed by means of Blakesleypsilas theorem. © Copyright 2010 IEEE - All Rights Reserved.

A Bayesian approach to estimate the accuracy of in-house ELISA assay to measure rabies antibodies from compulsory vaccinated dogs and cattle

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Lower-semicontinuity and optimization of convex functionals

The result that we treat in this article allows to the utilization of classic tools of convex analysis in the study of optimality conditions in the optimal control convex process for a Volterra-Stietjes linear integral equation in the Banach space G([a, b],X) of the regulated functions in [a, b], that is, the functions f : [a, 6] → X that have only descontinuity of first kind, in Dushnik (or interior) sense, and with an equality linear restriction. In this work we introduce a convex functional Lβf(x) of Nemytskii type, and we present conditions for its lower-semicontinuity. As consequence, Weierstrass Theorem garantees (under compacity conditions) the existence of solution to the problem min{Lβf(x)}. © 2009 Academic Publications.

Estimação de frequência usando sensores de erro com atrasos adaptativos

This paper proposes a solution to improve the performance of the first order Early Error Sensing (EES) Adaptive Time Delay Tanlock Loops (ATDTL) presented in (Al-Zaabi, Al-Qutayri e Al-Araji, 2005), regarding to frequency estimation and tracking time. The EES-ATDTL are phaselocked-loops (PLL) used to hardware implementations, due to their simple structure. Fixed-points theorems are used to determine conditions for rapid convergence of the estimation process and a estimative of the frecuency input is obtained with a Gaussian filter that improves the gain adaptation. The mathematical models are the presented by (Al-Araji, Al-Qutayri e Al-Zaabi, 2006). Simulations have been performed to evaluate the theoretical results.