Former Premcor Refinery, Blue Island, Illinois : environmental investigations : progress update, Fall 2005 = Antigua Refineri a Premcor, Blue Island, Illinois : investigaciones ambientales : actualizacio n de progresos, octon o de 2005 /

Updates on-site environmental investigations by the PREMCOR Refining Group at the former Clark-Blue Island Refinery which began operations as the Great Lakes Refinery in the mid 1920s and continued operating at the Blue Island (Ill.) site until PREMCOR closed the refinery in 2001. Valero Energy Corporation purchased PREMCOR on Sept. 1, 2005.

General Fibrosis & Subinvolution of Uterus, drawn by E.S. Perry, 4/11/1922

Carbon dust on Ross Stipple Board with water color added

Investigaciones historicas de las antiguedades del Reyno de Navarra /

Mode of access: Internet.

Cystic fibrosis : a disease in search of ideas.

v. 1 Basic sciences.--v. 2 Clinical sciences.

Trabajos del Laboratorio de Investigaciones Biológicas

On t.p., v. 29-31: Trav. biol. Cajal

Investigaciones de Seminario

Mode of access: Internet.

Reseña del libro de María Angélica Corva: "Constituir el gobierno, afianzar la justicia. El Poder Judicial de la provincia de Buenos Aires (1853-1881)". 1a ed. Rosario. Prohistoria Ediciones; Ciudad Autónoma de Buenos Aires. Instituto de Investigaciones

Fil: Calandria, María Sol. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación. Instituto de Investigaciones en Humanidades y Ciencias Sociales (UNLP-CONICET); Argentina.

¿Qué significa tener una beca de estudio de la Comisión de Investigaciones Científicas de la Provincia de Buenos Aires? Relato de una experiencia

Las becas que otorga la Comisión de Investigaciones Científicas de la Provincia de Buenos Aires (CIC) cada año se presentan como una opción interesante para alumnos avanzados y graduados que deseen iniciarse en la investigación científica y técnica. Tradicionalmente, el área de desempeño laboral y profesional de los graduados de las carreras de Licenciatura y Profesorado en Educación Física ha sido la docencia, por ello, este documento tiene por objetivo explicar, a partir de una experiencia personal, qué se requiere para acceder a una Beca de Estudio de la Comisión de Investigaciones Científicas de la Provincia de Buenos Aires y cuáles son los antecedentes más importantes para la aprobación de este tipo de beca. Se expondrá el plan de investigación de la autora, el cual fue aprobado y continúa en actividad al momento, y por último, se describirán las tareas que el becario debe desempeñar una vez obtenida la Beca de Estudio

Aplicación del Análisis de Redes Sociales [ARS] a la generación de mapas bibliométricos que caracterizan el uso de revistas por parte de investigadores. La experiencia de la Biblioteca del Centro de Investigaciones Opticas [CONICET-CIC]

Se presenta en este trabajo una aproximación metodológica al estudio de uso de revistas por parte de los investigadores del Centro de Investigaciones Opticas. Integrando la técnica de Análisis de Citaciones y de Análisis de Redes Sociales se realiza la construcción de mapas con gran capacidad de síntesis de información compleja. Se estima que su elaboración contribuiría con información valiosa a la hora de pensar la distribución equitativa de recursos económicos para compra de títulos

Pro-fibrotic polymorphisms predictive of advanced liver fibrosis in the severely obese

Background/Aims: Insulin resistance and systemic hypertension are predictors of advanced fibrosis in obese patients with non-alcoholic fatty liver disease (NAFLD). Genetic factors may also be important. We hypothesize that high angiotensinogen (AT) and transforming growth factor-beta1 (TGF-beta1) producing genotypes increase the risk of liver fibrosis in obese subjects with NAFLD. Methods: One hundred and five of 130 consecutive severely obese patients having a liver biopsy at the time of laparoscopic obesity surgery agreed to have genotype analysis. Influence of specific genotype or combination of genotypes on the stage of hepatic fibrosis was assessed after controlling for known risk factors. Results: There was no fibrosis in 70 (67%), stages 1-2 in 21 (20%) and stages 3-4 fibrosis in 14 (13%) of subjects. There was no relationship between either high AT or TGF-beta1 producing genotypes alone and hepatic fibrosis after controlling for confounding factors. However, advanced hepatic fibrosis occurred in five of 13 subjects (odds ratio 5.7, 95% confidence interval 1.5-21.2, P = 0.005) who inherited both high AT and TGF-beta1 producing polymorphisms. Conclusions: The combination of high AT and TGF-beta1 producing polymorphisms is associated with advanced hepatic fibrosis in obese patients with NAFLD. These findings support the hypothesis that angiotensin II stimulated TGF-beta1 production may promote hepatic fibrosis. (C) 2003 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

GFP-tagged CFTR transgene is functional in the G551D cystic fibrosis mouse colon

Trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) is central to its function, with the most common mutation, DeltaF508, resulting in abnormal processing and trafficking. Therefore, there is a significant need to develop tools, which enable the trafficking of CFTR to be studied in vitro and in vivo. In previous studies it has been demonstrated that fusion of the green fluorescent protein (GFP) to the N-terminus of CFTR does lead to functional expression of CFTR chloride channels in epithelial cell lines. The aim of the present study was to examine whether it is possible to express GFP-tagged CFTR as a transgene in colonic and airway epithelial cells of cystic fibrosis (CF) mice and to correct the CF defect. Using the epithelial-specific human cytokeratin promoter K18, we generated bitransgenic mice cftr(G551D/G551D) K18-GFP-CFTR+/-, designated GFP mice. Transcripts for GFP-CFTR could be detected in bitransgenic mice by use of RT-PCR techniques. Expression of GFP-CFTR protein was detected specifically in the colonic epithelium by both direct GFP fluorescence and the use of an anti-GFP antibody. Ussing chamber studies showed that the ion transport defect in colon and airways observed in cftr(G551D/G551D) mice was partially corrected in the bitransgenic animals. Thus, K18-GFP-CFTR is functionally expressed in transgenic mice, which will be a valuable tool in studies on CFTR synthesis, processing and ion transport in native epithelial tissues.