A Psychological Exploration of Long-Term LSD Users

All research involving the psychoactive compound lysergic acid diethylamide (LSD) was terminated globally following its prohibition more than 50 years ago, though illicit use remained fairly stable. A considerable resurgence of research interest in LSD has received considerable attention in various publications and professional fora. One of the main applications considered is LSD-assisted psychotherapy to address a number of difficulties like end-of-life anxiety, addiction/alcoholism, post-traumatic stress, and depression. However, due to the highly contradictory nature of early research findings and division in the literature, one is left uncertain as to whether psychology as a profession is currently equipped to critically evaluate these advances, let alone embrace them. The purpose of the present study was to contribute to current psychological knowledge on long-term LSD use. A group of long-term LSD users who claimed beneficial use were the focus here. A mixed methods design was employed. 110 users completed an online survey assessing for demographics, patterns of use, and specific personality traits through three psychometric measures, Big Five Inventory (BFI), General Self Efficacy scale (GSE) and Satisfaction With Life Scale (SWLS). Eight individual interviews were also conducted and analysed by Thematic Analysis (TA). Gaining different perspectives on reality and increasing self- awareness appeared to be essential elements of the belief system that these non-problematic long-term LSD users adopted in order to make sense of their LSD use. Qualitative findings also suggested the existence of a common set of life values, rules and the adoption of a hierarchical system between LSD users. Novices appeared to be tutored and guided by elders whose presence and input was valued and who were listened to and respected. A role for ‘wiser/elder’ users as those imparting valuable knowledge to novices was therefore also suggested. The underlying aim may possibly be an attempt to minimise risks and maximise potential benefits of LSD use. A prospective role for LSD as a deterrent of substance misuse, a ‘gateway drug to no drugs’ was also hinted and remains in need of iv further investigation. Claims regarding beneficial LSD use and ‘change’ through LSD use were confirmed by the participant sample. No noteworthy differences between psychometric scores of the LSD-using group and those of the general population (as suggested by normative data comparisons) were found, possibly due to methodological limitations, especially considering the highly subjective nature of the LSD experience and its effects. The determining role of extra-pharmacological variables or ‘set and setting’ in the outcome of LSD use suggested in earlier literature was re-validated. Knowledge on their specific components was enriched, and a potentially significant value for adopting a flexible, adaptable and solution-focused mind-set in order to better manage the effects of LSD was highlighted. Due to the highly selected nature of the participant sample, present findings should serve as suggestions for further research in order to clarify the aforementioned issues and to make explicit the mechanisms by which they operate. The complex nature of LSD, its use and its effects have been re-confirmed here. It is imperative that the current knowledge base on the substance is enriched before LSD is introduced in a clinical psychology professional context.

Intimate Ecologies: An exploration of the languages of contemporary exhibitions and making in museums and related cultural spaces in the UK

Intimate Ecologies considers the practice of exhibition-making over the past decade in formal museum and gallery spaces and its relationship to creating a concept of craft in contemporary Britain. Different forms of expression found in traditions of still life painting, film and moving image, poetic text and performance are examined to highlight the complex layers of language at play in exhibitions and within a concept of craft. The thesis presents arguments for understanding the value of embodied material knowledge to aesthetic experience in exhibitions, across a spectrum of human expression. These are supported by reference to exhibition case studies, critical and theoretical works from fields including social anthropology, architecture, art and design history and literary criticism and a range of individual, original works of art. Intimate Ecologies concludes that the museum exhibition, as a creative medium for understanding objects, becomes enriched by close study of material practice, and embodied knowledge that draws on a concept of craft. In turn a concept of craft is refreshed by the makers’ participation in shifting patterns of exhibition-making in cultural spaces that allow the layers of language embedded in complex objects to be experienced from different perspectives. Both art-making and the experience of objects are intimate, and infinitely varied: a vibrant ecology of exhibition-making gives space to this diversity.

The downy mildew resistance locus Pp523 is located on chromosome C8 of Brassica oleracea L.

We have previously constructed a genetic map of Brassica oleracea L. containing the Pp523 locus that confers downy mildew resistance to adult plants. In this work, 44 SSR markers of reference for the Brassica C genome chromosomes were added to the map, allowing the nine major linkage groups to be assigned to the nine chromosomes of B. oleracea. Locus Pp523 was located on chromosome C8, and a locus determining flower colour was mapped to chromosome C3. In comparison with the first version of the map, the new map is denser and more compact. The available genomic information on B. oleracea was enriched with the chromosome location of two phenotypic traits and 421 DNA markers (RAPD, ISSR, AFLP, SCAR, BAC-end derived STS, SSR and other PCR markers). Conversely, the genomic information on B. oleracea chromosome C8 is being used as an additional tool for the map-based cloning of Pp523, the first gene for adult plant resistance to downy mildew precisely located to a specific chromosome of this crop species.

Notable differences in gene expression between injured turbot (Scophthalmus maximus) and brill (Scophthalmus rhombus) skin

Dissertação de mestrado, Engenharia Biológica, Faculdade de Ciências e Tecnologia, Universidade do Algarve, 2015

Incorporation of selenium on microalgae as supplement to artemia and zebrafish

Dissertação de mestrado, Aquacultura, Faculdade de Ciências e Tecnologia, Universidade do Algarve, 2015

Constitutive OGG1 variant together with BRCA mutations display accelerated telomere shortening

Dissertação de mestrado, Oncobiologia, Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, 2015

Automatic classification of scientific records using the German Subject Heading Authority File (SWD)

The following paper deals with an automatic text classification method which does not require training documents. For this method the German Subject Heading Authority File (SWD), provided by the linked data service of the German National Library is used. Recently the SWD was enriched with notations of the Dewey Decimal Classification (DDC). In consequence it became possible to utilize the subject headings as textual representations for the notations of the DDC. Basically, we we derive the classification of a text from the classification of the words in the text given by the thesaurus. The method was tested by classifying 3826 OAI-Records from 7 different repositories. Mean reciprocal rank and recall were chosen as evaluation measure. Direct comparison to a machine learning method has shown that this method is definitely competitive. Thus we can conclude that the enriched version of the SWD provides high quality information with a broad coverage for classification of German scientific articles.

Informationsberatung als zeitgemäßes Dienstleistungskonzept für wissenschaftliche Bibliotheken

Ausgangspunkt für die vorliegende Arbeit ist die These, dass Informationsberatung in Anlehnung an die in den USA verbreiteten Research Consultations eine ergänzende Methode zur prozessorientierten Förderung von Informationskompetenz an wissenschaftlichen Bibliotheken sein kann. Im Zuge der Diskussion dieser These werden zunächst die der Dienstleistung zugrunde liegenden Konzepte wie etwa das Rollenverständnis des consultant librarian und das des counseling librarian vorgestellt. Daraufhin wird die in der Fachliteratur geführte Diskussion um die Einordnung der Dienstleistung aufgegriffen und Informationsberatung gegenüber den herkömmlichen Dienstleistungen Auskunftsdienst und Informationskompetenzschulung abgegrenzt. Dabei zeigt sich, dass professionelle bibliothekarische Beratung im Zuge der Förderung des informellen Lernens einen neuen, eigenständigen und nutzerorientierten Service darstellt, der den aktuellen Bedarf nach individueller Betreuung durch persönliche Ansprechpartner und Expertenberatung deckt. Durch die inhaltliche und zeitliche Flexibilität der Dienstleistung können Nutzer am point of need abgeholt werden. Umsetzungsmodelle finden sich bspw. an der Wissensbar der SLUB Dresden, dem Helpdesk Lern- und Arbeitstechniken an der KIT-Bibliothek und dem Learning Center der Universitätsbibliothek Mannheim. Seitens der Berater werden u.a. Kompetenzen im Bereich des wissenschaftlichen Arbeitens sowie Kommunikations- und Sozialkompetenzen benötigt. Neben der Qualifizierung des bibliothekseigenen Personals durch Fortbildungen stellen Kooperationen mit kompetenzbildenden Einrichtungen der Universität eine Möglichkeit zur Implementierung der Dienstleistung dar, die von entsprechenden Marketingmaßnahmen begleitet sein muss. Abschließend wird die Rolle von wissenschaftlichen Bibliotheken im Hinblick auf die an deutschen Universitäten zunehmend etablierten Schreibzentren diskutiert.

O papel do lúdico na aprendizagem matemática

Trabalho de projecto de mestrado, Educação (Didáctica da Matemática), Universidade de Lisboa, Instituto de Educação, 2011

Évaluation de l’impact de pansements biologiques humains produits par génie tissulaire sur la guérison de plaies cutanées murines

L’étude de la guérison des plaies à l’aide de substituts produits par génie tissulaire est un domaine en plein essor. Dans ces travaux, les effets de pansements biologiques produits en laboratoire à partir de cellules souches/stromales du tissu adipeux (CSTA) différenciées ou non en adipocytes ont été évalués sur des plaies cutanées in vivo. Un modèle de souris possédant un épiderme fluorescent a permis de démontrer que les plaies traitées avec les pansements biologiques guérissent plus rapidement que les plaies non traitées, et ce, de manière indépendante de la réépithélialisation. Une augmentation de la formation du tissu de granulation et une angiogenèse accrue ont également été observées dans les groupes traités. Ces résultats établissent que les substituts contenant des CSTA ou des adipocytes fonctionnels favorisent la réparation tissulaire. À terme, ces travaux pourraient mener au développement de nouvelles indications cliniques pour le traitement des ulcères cutanés.

Analysis of RNA-seq data from the interaction of Coffea spp. - Colletotrichum kahawae

Tese de mestrado em Bioinformática e Biologia Computacional (Bioinformática), apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2014

Between Library and Research Centre: Metadata and Criticism

Abstract: In order to promote the transfer of information and the development of knowledge, university librarians should proactively work with the academic community in well-organized transdisciplinary teams—involving teachers, researchers, students, and experts in various subjects. The concept of this very innovative practice has been developed and tested by the Faculty of Humanities Library, Lisbon University, and the University of Lisbon Centre for English Studies, focusing on the role played by libraries in canon-formation. We will now proceed to build an interactive website to publish our theoretical perspectives along with bibliographic records (UNIMARC format), including metadata related to marks of use. Furthermore, Richard Garnett’s “The International Library of Famous Literature” (London 1899), bio/bibliographical essays on Garnett as a scholar and librarian, and critical essays on the anthology will be published there. A link to the English edition is the next follow-up. Finally, two volumes of the Portuguese anthology (ca. 1910), based on the English one will also be made available on the website.

Contigo eu posso : caminhos da aprendizagem de uma menina com Síndrome de Down

Dissertação de mestrado, Ciências da Educação (Área de especialização em Educação Intercultural), Universidade de Lisboa. Instituto de Educação, 2015

Translating proteomics into environmental health : biomarkers discovery for tobacco smoke-induced biological damage

Tese de doutoramento, Biologia (Biologia Molecular), Universidade de Lisboa, Faculdade de Ciências, 2015

Contributos para a compreensão do sucesso da cosmologia do big bang : uma análise themática à luz de Gerald Holton

Tese de doutoramento, História e Filosofia das Ciências, Universidade de Lisboa, Faculdade de Ciências, 2016