Probabilité et statistique pour les sciences de la santé : apprentissage au moyen du logiciel Stata

Cet ouvrage non seulement présente, de façon rigoureuse, les concepts et méthodes statistiques, mais aussi utilise des exemples concrets pour illustrer chaque concept théorique nouvellement introduit. Il présente de façon méticuleuse les notions fondamentales de la théorie des probabilités et de la statistique: bref rappel de l'histoire de la statistique, la statistique descriptive, les distributions discrètes et continues, estimation, tests d'hypothèses, l'analyse de corrélation, l'analyse de régression linéaire simple et multiple, et le modèle d'analyse de variance. Au moyen des exemples et exercices, le lecteur est guidé tout au long de la réalisation du problème. En même temps, l'apprentissage de l'utilisation de Stata se fait progressivement au fil des chapitres. La dernière partie de l'ouvrage propose une introduction à l'utilisation de Stata. Les corrections des exercices figurent à la fin de l'ouvrage, permettant au lecteur de vérifier le niveau de compréhension atteint après chaque étape.

Cellular source and mechanisms of high transcriptome complexity in the Mammalian testis.

Understanding the extent of genomic transcription and its functional relevance is a central goal in genomics research. However, detailed genome-wide investigations of transcriptome complexity in major mammalian organs have been scarce. Here, using extensive RNA-seq data, we show that transcription of the genome is substantially more widespread in the testis than in other organs across representative mammals. Furthermore, we reveal that meiotic spermatocytes and especially postmeiotic round spermatids have remarkably diverse transcriptomes, which explains the high transcriptome complexity of the testis as a whole. The widespread transcriptional activity in spermatocytes and spermatids encompasses protein-coding and long noncoding RNA genes but also poorly conserves intergenic sequences, suggesting that it may not be of immediate functional relevance. Rather, our analyses of genome-wide epigenetic data suggest that this prevalent transcription, which most likely promoted the birth of new genes during evolution, is facilitated by an overall permissive chromatin in these germ cells that results from extensive chromatin remodeling.

Dissecting the role of low-complexity regions in the evolution of vertebrate proteins

Low-complexity regions (LCRs) in proteins are tracts that are highly enriched in one or a few aminoacids. Given their high abundance, and their capacity to expand in relatively short periods of time through replication slippage, they can greatly contribute to increase protein sequence space and generate novel protein functions. However, little is known about the global impact of LCRs on protein evolution. We have traced back the evolutionary history of 2,802 LCRs from a large set of homologous protein families from H.sapiens, M.musculus, G.gallus, D.rerio and C.intestinalis. Transcriptional factors and other regulatory functions are overrepresented in proteins containing LCRs. We have found that the gain of novel LCRs is frequently associated with repeat expansion whereas the loss of LCRs is more often due to accumulation of amino acid substitutions as opposed to deletions. This dichotomy results in net protein sequence gain over time. We have detected a significant increase in the rate of accumulation of novel LCRs in the ancestral Amniota and mammalian branches, and a reduction in the chicken branch. Alanine and/or glycine-rich LCRs are overrepresented in recently emerged LCR sets from all branches, suggesting that their expansion is better tolerated than for other LCR types. LCRs enriched in positively charged amino acids show the contrary pattern, indicating an important effect of purifying selection in their maintenance. We have performed the first large-scale study on the evolutionary dynamics of LCRs in protein families. The study has shown that the composition of an LCR is an important determinant of its evolutionary pattern.

Complexitat i fenomen (socio)linguístic

Intermediate phenomena of reality present particular characteristics of systemic self-organization, multilevel interrelations, recursivity, emergence of new «objects» with properties different from those of the elements that form them, and evolutionary dynamics, that probably need the formulation of new theoretical concepts and different paradigm principles. The sciences or perspectives of complexity, or the «complex» thinking, try to respond adequately to this complexity of reality. This approach adopts a multidimensional, integrated and dynamic view of reality: the world is made up of overlapping levels of different elements which produce new properties or new organizations at higher levels. If we conceive what we call languages as simple and decontextualized objects, we can understand some of the more mechanical aspects but we will ignore their conditions of existence, functionality, maintenance, variation, change and extinction.

Impact of controlled changes in grain size and pore space characteristics on the hydraulic conductivity and spectral induced polarization response of "proxies" of saturated alluvial sediments

Understanding the influence of pore space characteristics on the hydraulic conductivity and spectral induced polarization (SIP) response is critical for establishing relationships between the electrical and hydrological properties of surficial unconsolidated sedimentary deposits, which host the bulk of the world's readily accessible groundwater resources. Here, we present the results of laboratory SIP measurements on industrial-grade, saturated quartz samples with granulometric characteristics ranging from fine sand to fine gravel, which can be regarded as proxies for widespread alluvial deposits. We altered the pore space characteristics by changing (i) the grain size spectra, (ii) the degree of compaction, and (iii) the level of sorting. We then examined how these changes affect the SIP response, the hydraulic conductivity, and the specific surface area of the considered samples. In general, the results indicate a clear connection between the SIP response and the granulometric as well as pore space characteristics. In particular, we observe a systematic correlation between the hydraulic conductivity and the relaxation time of the Cole-Cole model describing the observed SIP effect for the entire range of considered grain sizes. The results do, however, also indicate that the detailed nature of these relations depends strongly on variations in the pore space characteristics, such as, for example, the degree of compaction. The results of this study underline the complexity of the origin of the SIP signal as well as the difficulty to relate it to a single structural factor of a studied sample, and hence raise some fundamental questions with regard to the practical use of SIP measurements as site- and/or sample-independent predictors of the hydraulic conductivity.

Stories in Agriculture and Life Sciences, Fall 2007

Stories we hope will inform and inspire you. Stories about how the college is constantly striving to make new discoveries, encourage and educate students and serve Iowans. Stories of the people who make this college one of the premier institutions of agriculture and life sciences in the world.

Stories in Agriculture and Life Sciences, Fall 2008

Stories we hope will inform and inspire you. Stories about how the college is constantly striving to make new discoveries, encourage and educate students and serve Iowans. Stories of the people who make this college one of the premier institutions of agriculture and life sciences in the world.

Stories in Agriculture and Life Sciences, Fall 2009

Stories we hope will inform and inspire you. Stories about how the college is constantly striving to make new discoveries, encourage and educate students and serve Iowans. Stories of the people who make this college one of the premier institutions of agriculture and life sciences in the world.