British colonial policy, 1754-1765.

Mode of access: Internet.

Medford in the Revolution : military history of Medford, Massachusetts, 1765-1783 : also list of soldiers and civil officers, with genealogical and biographical notes /

Mode of access: Internet.

Dem edlen, unvergesslichen Johann Christian von Senckenberg Med. Doct. & Phys. Ord. welcher sich um Frankfurt und die leidende Menschheit und sein ganzes höchst ansehnliches Vermögen zur Gründung einer medicinischen Stiftung, und zu einem Bürger und Beisassen Hospital in seinem Testamente vom 18. August 1765 vermachte : er war gebohren am 28. Februar 1707 : ein unglücklicher Fall endigte am 15. November 1772 sein thatenreiches Leben : einem hohen Senate und löblicher Bürgerschaft der Freien Stadt Frankfurt ehrfurchtsvoll gewidmet von: Soldan Rohm

nach der Originalzeichnung von L. Müller ; entworfen und herausgegeben von: Soldan Rohm

A discourse delivered before the Rhode-Island Historical Society, on the evening of Thursday February 1, 1849. Published at the request of the Society.

"Sketch of the progress of historical science."

A importância e a influência do génio de Frédéric Chopin (1810-1849) na vida e obra do pianista e compositor Milosz Magin (1929-1999)

Este Trabalho de Projecto é composto por duas partes: uma de índole teórica e outra de índole prática. No que diz respeito a parte teórica, ela compõe-se por uma exposição que se divide em quatro capítulos. O primeiro capítulo toma como ponto de partida a apresentação da vida de Milosz Magin, um pianista e compositor europeu da segunda metade do século XX. Os objectivos do segundo capítulo são os de salientar e explicar a influência que Frédéric Chopin teve na vida de Milosz Magin. Este capítulo centra-se nos paralelismos biográficos entre ambos, essencialmente, naqueles que dizem respeito às suas vidas enquanto pianistas e compositores. O terceiro capítulo inclui o estudo analítico e comparativo das semelhanças entre a Sonata em sí bemol menor op. 35 de Frédéric Chopin e a Sonata n.º 1 de Milosz Magin. O quarto capítulo analisa a Mazurka em fá menor op. póstuma de Frédéric Chopin, a qual foi, completamente, reconstruída por Milosz Magin. Ela constitui mais um exemplo paradigmático da influência e importância de Frédéric Chopin na obra do compositor. ABSTRACT: This Project consists of two parts: one of a theoretical nature and the other of a practical one. The theoretical part is in itself made up of an exposition divided into four parts. The first chapter deals with the presentation of Milosz Magin's life, European pianist and composer from the second half of the 20th Century. The objective of the second chapter is to emphasize and explain the influence that Frédéric Chopin had on the life of Milosz Magin. It will concentrate on the biographical parallelisms between Frédéric Chopin and Milosz Magin, essentially on those that concern their lives as pianists and composers. The third chapter includes an analytical and comparative study of the similarities between the Sonata in B Flat minor Op. 35 by Frédéric Chopin and the Sonata n° 1 by Milosz Magin. The fourth chapter analyzes the Mazurka in F minor op. posthume by Frédéric Chopin, completely reconstructed by Milosz Magin, which in itself establishes one more example of the influence and importance Frédéric Chopin had on the works of Milosz Magin.

[lean Production And Psychosocial Risks: The Case Of A Multinational Merger In A Metallurgical Company In Brazil].

This study focused on the method known as lean production as a work-related psychosocial risk factor in a Brazilian multinational auto parts company after its merger with other multinational companies. The authors conducted a qualitative analysis of two time points: the first using on-site observation and key interviews with managers and workers during implementation of lean production in 1996; the second, 16 years later, comparing data from a document search in labor inspection records from the Ministry of Labor and Employment and legal proceedings initiated by the Office of the Public Prosecutor for Labor Affairs. The merger led to layoffs, replacements, and an increase in the workday. A class action suit was filed on grounds of aggravated working conditions. The new production model led to psychosocial risks that increased the need for workers' health precautions when changes in the production process introduced new and increased risks of physical and mental illnesses.

Diagnostic and clinical factors associated with pulpal and periapical pain

A retrospective survey was designed to identify diagnostic subgroups and clinical factors associated with odontogenic pain and discomfort in dental urgency patients. A consecutive sample of 1,765 patients seeking treatment for dental pain at the Urgency Service of the Dental School of the Federal University of Goiás, Brazil, was selected. Inclusion criteria were pulpal or periapical pain that occurred before dental treatment (minimum 6 months after the last dental appointment), and the exclusion criteria were teeth with odontogenic developmental anomalies and missing information or incomplete records. Clinical and radiographic examinations were performed to assess clinical presentation of pain complaints including origin, duration, frequency and location of pain, palpation, percussion and vitality tests, radiographic features, endodontic diagnosis and characteristics of teeth. Chi-square test and multiple logistic regression were used to analyze association between pulpal and periapical pain and independent variables. The most frequent endodontic diagnosis of pulpal pain were symptomatic pulpitis (28.3%) and hyperreactive pulpalgia (14.4%), and the most frequent periapical pain was symptomatic apical periodontitis of infectious origin (26.4%). Regression analysis revealed that closed pulp chamber and caries were highly associated with pulpal pain and, conversely, open pulp chamber was associated with periapical pain (p<0.001). Endodontic diagnosis and local factors associated with pulpal and periapical pain suggest that the important clinical factor of pulpal pain was closed pulp chamber and caries, and of periapical pain was open pulp chamber.

Interleukin-22 forms dimers that are recognized by two interleukin-22R1 receptor chains

Interleukin-22 (IL-22) is a class 2 cytokine whose primary structure is similar to that of interleukin 10 (IL-10) and interferon-gamma (IFN-gamma). IL-22 induction during acute phase immune response indicates its involvement in mechanisms of inflammation. Structurally different from IL-10 and a number of other members of IL-10 family, which form intertwined inseparable V-shaped dimers of two identical polypeptide chains, a single polypeptide chain of IL-22 folds on itself in a relatively globular structure. Here we present evidence, based on native gel electrophoresis, glutaraldehyde cross-linking, dynamic light scattering, and small angle x-ray scattering experiments, that human IL-22 forms dimers and tetramers in solution under protein concentrations assessable by these experiments. Unexpectedly, low-resolution molecular shape of IL-22 dimers is strikingly similar to that of IL-10 and other intertwined cytokine dimeric forms. Furthermore, we determine an ab initio molecular shape of the IL-22/IL-22R1 complex which reveals the V-shaped IL-22 dimer interacting with two cognate IL-22R1 molecules. Based on this collective evidence, we argue that dimerization might be a common mechanism of all class 2 cytokines for the molecular recognition with their respective membrane receptor. We also speculate that the IL-22 tetramer formation could represent a way to store the cytokine in nonactive form at high concentrations that could be readily converted into functionally active monomers and dimers upon interaction with the cognate cellular receptors.

Does Training Laparoscopic Skills in a Virtual Reality Simulator Improve Surgical Performance?

Background and Purpose: Several different methods of teaching laparoscopic skills have been advocated, with virtual reality surgical simulation (VRSS) being the most popular. Its effectiveness in improving surgical performance is not a consensus yet, however. The purpose of this study was to determine whether practicing surgical skills in a virtual reality simulator results in improved surgical performance. Materials and Methods: Fifteen medical students recruited for the study were divided into three groups. Group I (control) did not receive any VRSS training. For 10 weeks, group II trained basic laparoscopic skills (camera handling, cutting skill, peg transfer skill, and clipping skill) in a VRSS laparoscopic skills simulator. Group III practiced the same skills and, in addition, performed a simulated cholecystectomy. All students then performed a cholecystectomy in a swine model. Their performance was reviewed by two experienced surgeons. The following parameters were evaluated: Gallbladder pedicle dissection time, clipping time, time for cutting the pedicle, gallbladder removal time, total procedure time, and blood loss. Results: With practice, there was improvement in most of the evaluated parameters by each of the individuals. There were no statistical differences in any of evaluated parameters between those who did and did not undergo VRSS training, however. Conclusion: VRSS training is assumed to be an effective tool for learning and practicing laparoscopic skills. In this study, we could not demonstrate that VRSS training resulted in improved surgical performance. It may be useful, however, in familiarizing surgeons with laparoscopic surgery. More effective methods of teaching laparoscopic skills should be evaluated to help in improving surgical performance.

Measurement of the depth of maximum of extensive air showers above 10(18) eV

We describe the measurement of the depth of maximum, X(max), of the longitudinal development of air showers induced by cosmic rays. Almost 4000 events above 10(18) eV observed by the fluorescence detector of the Pierre Auger Observatory in coincidence with at least one surface detector station are selected for the analysis. The average shower maximum was found to evolve with energy at a rate of (106 +/- 35-21) g/cm(2)/decade below 10(18.24) +/- (0.05) eV, and d24 +/- 3 g/cm(2)/ecade above this energy. The measured shower-to-shower fluctuations decrease from about 55 to 26 g/cm(2). The interpretation of these results in terms of the cosmic ray mass composition is briefly discussed.