Bone mineral density in breast cancer patients treated with adjuvant letrozole, tamoxifen, or sequences of letrozole and tamoxifen in the BIG 1-98 study (SAKK 21/07).

BACKGROUND: The risk of osteoporosis and fracture influences the selection of adjuvant endocrine therapy. We analyzed bone mineral density (BMD) in Swiss patients of the Breast International Group (BIG) 1-98 trial [treatment arms: A, tamoxifen (T) for 5 years; B, letrozole (L) for 5 years; C, 2 years of T followed by 3 years of L; D, 2 years of L followed by 3 years of T]. PATIENTS AND METHODS: Dual-energy X-ray absorptiometry (DXA) results were retrospectively collected. Patients without DXA served as control group. Repeated measures models using covariance structures allowing for different times between DXA were used to estimate changes in BMD. Prospectively defined covariates were considered as fixed effects in the multivariable models. RESULTS: Two hundred and sixty-one of 546 patients had one or more DXA with 577 lumbar and 550 hip measurements. Weight, height, prior hormone replacement therapy, and hysterectomy were positively correlated with BMD; the correlation was negative for letrozole arms (B/C/D versus A), known osteoporosis, time on trial, age, chemotherapy, and smoking. Treatment did not influence the occurrence of osteoporosis (T score < -2.5 standard deviation). CONCLUSIONS: All aromatase inhibitor regimens reduced BMD. The sequential schedules were as detrimental for bone density as L monotherapy.

List of Bid Proposal Holders, July 21, 2015

List of Bid Proposal Holders

Water Summary Update, May 21, 2015, No. 51

A snapshot of water resource trends prepared by the Iowa DNR in collaboration with the Iowa Department of Agriculture and Land Stewardship, the U.S. Geological Survey, and The Iowa Homeland Security and Emergency Management Department.

The Revenue Estimating Conference (REC) Estimate of General Fund Receipts Report, February 21, 2002

State general fund revenue estimates are generated by the Iowa Revenue Estimating Conference (REC). The REC is comprised of the Governor or their designee, the Director of the Legislative Services Agency, and a third person agreed upon by the other two members. The REC meets periodically, generally in October, December, and March/April. The Governor and the Legislature are required to use the REC estimates in preparing the state budget.

Friday Facts, August 21, 2015, Vol. 262

Bureau of Nutrition and Health Promotion part of the Iowa Department of Public Health produces of weekly newsletter about the Iowa WIC Program for the State of Iowa citizen.

Farm Families Alive and Well, September 2015, Vol. 21, no. 4

News from Iowa’s Center for Agricultural Safety and Health (I-CASH)

Monday Morning Eye Opener, September 21, 2015

Weekly Newsletter from the Northwest District Office for libraries containing programs, activities, classes for the upcoming week.

Iowa Crop Progress & Condition, September 21, 2015

Report produced by the The Department of Agriculture and Land Stewardship, Climatology Bureau. Weather report released by the USDA National Agricultural Statistical Service. The report is released weekly from April through October. Formally titled: Iowa Crop and Weather Report

Water Summary Update, February 21, 2014, No. 30

A snapshot of water resource trends prepared by the Iowa DNR in collaboration with the Iowa Department of Agriculture and Land Stewardship, the U.S. Geological Survey, and The Iowa Homeland Security and Emergency Management Department.

EPI Update, August 21, 2015

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health.

Iowa AgriNews, October 26, 2015, Vol. 15, no. 21

Crop and livestock summaries for the state of Iowa, produced by the Iowa Department of Agriculture. Previously Agri-News

21

Le management des organisations publiques a considérablement évolué durant ces dernières trois ou quatre dernières décennies : pression accrue sur les résultats, accroissement de l'autonomie dans l'utilisation des ressources et la fixation de priorités, exigences élevées en matière d'accountability, intérêt des citoyens et des médias pour les décisions et l'action publiques, etc. Des outils de management issus pour partie de l'économie privée et pour l'autre développés spécifiquement pour le secteur public ont complété la palette instrumentale à disposition des managers publics. Parmi ces outils, la communication joue un rôle important tant à l'intérieur de l'organisation que par rapport à l'ensemble de ses partenaires et de la collectivité en général. En effet, les responsables de l'action publique doivent de manière croissante présenter les enjeux de politiques publiques, expliquer les décisions prises, justifier des mesures correspondantes et être à l'écoute des besoins et demandes formulés par les bénéficiaires des prestations.