959 resultados para 3D printing technology


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Technology News is a newsletter produced by the Iowa Department of Transportation to provide information to the transportation specialist in Iowa's cities and counties. Technology News is one of CTRE's primary avenues for exchanging transportation-related information with local agencies. The bimonthly newsletter gives an up-to-date look to the up-to-date information our 2,500+ readers have grown to expect.

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Technology News is a newsletter produced by the Iowa Department of Transportation to provide information to the transportation specialist in Iowa's cities and counties. Technology News is one of CTRE's primary avenues for exchanging transportation-related information with local agencies. The bimonthly newsletter gives an up-to-date look to the up-to-date information our 2,500+ readers have grown to expect.

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Technology News is a newsletter produced by the Iowa Department of Transportation to provide information to the transportation specialist in Iowa's cities and counties. Technology News is one of CTRE's primary avenues for exchanging transportation-related information with local agencies. The bimonthly newsletter gives an up-to-date look to the up-to-date information our 2,500+ readers have grown to expect.

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Technology News is a newsletter produced by the Iowa Department of Transportation to provide information to the transportation specialist in Iowa's cities and counties. Technology News is one of CTRE's primary avenues for exchanging transportation-related information with local agencies. The bimonthly newsletter gives an up-to-date look to the up-to-date information our 2,500+ readers have grown to expect.

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Technology News is a newsletter produced by the Iowa Department of Transportation to provide information to the transportation specialist in Iowa's cities and counties. Technology News is one of CTRE's primary avenues for exchanging transportation-related information with local agencies. The bimonthly newsletter gives an up-to-date look to the up-to-date information our 2,500+ readers have grown to expect.

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Technology News is a newsletter produced by the Iowa Department of Transportation to provide information to the transportation specialist in Iowa's cities and counties. Technology News is one of CTRE's primary avenues for exchanging transportation-related information with local agencies. The bimonthly newsletter gives an up-to-date look to the up-to-date information our 2,500+ readers have grown to expect.

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Technology News is a newsletter produced by the Iowa Department of Transportation to provide information to the transportation specialist in Iowa's cities and counties. Technology News is one of CTRE's primary avenues for exchanging transportation-related information with local agencies. The bimonthly newsletter gives an up-to-date look to the up-to-date information our 2,500+ readers have grown to expect.

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Technology News is a newsletter produced by the Iowa Department of Transportation to provide information to the transportation specialist in Iowa's cities and counties. Technology News is one of CTRE's primary avenues for exchanging transportation-related information with local agencies. The bimonthly newsletter gives an up-to-date look to the up-to-date information our 2,500+ readers have grown to expect.

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Xenobiotic exposure is a risk factor in the etiology of neurodegenerative disease. It was recently hypothesized that restricted exposure during brain development could predispose for a neurodegenerative disease later in life. As neuroinflammation contributes to progressive neurodegeneration, it is suspected that neurodevelopmental xenobiotic exposure could elicit a neuroinflammatory process, which over time may assume a detrimental character. We investigated the neurotoxic effects of paraquat (PQ) in three-dimensional whole rat brain cell cultures, exposed during an early differentiation stage, comparing immediate effects-directly post exposure-with long-term effects, 20 days after interrupted PQ-administration. Adverse effects and neuroinflammatory responses were assessed by measuring changes in gene- and protein-expression as well as by determining cell morphology changes. Differentiating neural cultures were highly susceptible to PQ and showed neuronal damage and strong astrogliosis. After the 20-day washout period, neurons partially recovered, whereas astrogliosis persisted, and was accompanied by microglial activation of a neurodegenerative phenotype. Our data shows that immediate and long-term effects of subchronic PQ-exposure differ. Also, PQ-exposure during this window of extensive neuronal differentiation led to a delayed microglial activation, of a character that could promote further pro-inflammatory signals that enable prolonged inflammation, thereby fueling further neurodegeneration.

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Background: To compare the different schemes that have been proposed during the last thirteen years to explain the renewal of the corneal epithelium. Material and Methods:We analyzed all the data present in the literature to explain the renewal of the corneal epithelium in mammals. According to the schemes proposed in the literature we developed a 3D animation to facilitate the understanding of the different concepts. Results:Three different schemes have been proposed to explain the renewal of the corneal epithelium in mammals during the last thirteen years. 1950-1981: the corneal epithelium was thought being renewed by mitosis of cells located in the basal layer. At this time scientist were not talking about stem cells. 1981-1986 was the period of the "XYZ hypothesis" or the transdifferentiation paradigm. At this time the conjunctival epithelium renewed the corneal epithelium in a centripetal migration. 1986-2008: the limbal stem cell paradigm, there were no stem cells in the corneal epithelium, all the corneal stem cells were located in the limbus and renewed the central cornea after a migration of 6 to 7 mm of transient amplifying cells toward the centre of the cornea. 2008, epithelial stem cells were found in the central cornea in mammals (Nature, Majo et al. November 2008). Discussion:We thought that the renewal of the corneal epithelium was completely defined. According to the last results we published in Nature, the current paradigm will be revisited. The experiments we made were on animals and the final demonstration on human has still to be done. If we find the same results in human, a new paradigm will be define and will change the way we consider ocular surface therapy and reconstruction.

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Report on Iowa State University of Science and Technology, Ames, Iowa, for the year ended June 30, 2012

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It has been shown that repolarization alternans, a beat-to-beat alternation in action potential duration, enhances dispersion of repolarization above a critical heart rate and promotes susceptibility to ventricular arrhythmias. It is unknown whether repolarization alternans is measurable in the atria using standard pacemakers and whether it plays a role in promoting atrial fibrillation. In this work, atrial repolarization alternans amplitude and periodicity are studied in a sheep model of pacing-induced atrial fibrillation. Two pacemakers, each with one right atrial and ventricular lead, were implanted in 4 male sheep after ablation of the atrioventricular junction. The first one was used to deliver rapid pacing for measurements of right atrial repolarization alternans and the second one to record a unipolar electrogram. Atrial repolarization alternans appeared rate-dependent and its amplitude increased as a function of pacing rate. Repolarization alternans was intermittent but no periodicity was detected. An increase of repolarization alternans preceding episodes of non-sustained atrial fibrillation suggests that repolarization alternans is a promising parameter for assessment of atrial fibrillation susceptibility.

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3D dose reconstruction is a verification of the delivered absorbed dose. Our aim was to describe and evaluate a 3D dose reconstruction method applied to phantoms in the context of narrow beams. A solid water phantom and a phantom containing a bone-equivalent material were irradiated on a 6 MV linac. The transmitted dose was measured by using one array of a 2D ion chamber detector. The dose reconstruction was obtained by an iterative algorithm. A phantom set-up error and organ interfraction motion were simulated to test the algorithm sensitivity. In all configurations convergence was obtained within three iterations. A local reconstructed dose agreement of at least 3% / 3mm with respect to the planned dose was obtained, except in a few points of the penumbra. The reconstructed primary fluences were consistent with the planned ones, which validates the whole reconstruction process. The results validate our method in a simple geometry and for narrow beams. The method is sensitive to a set-up error of a heterogeneous phantom and interfraction heterogeneous organ motion.