15/2/20, Thionville [M. Poincaré avec à sa droite la grande-duchesse de Luxembourg, cérémonie de remise de la croix d'honneur à la ville] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58024

15/2/20, M. Poincaré à Thionville [avec à sa droite la grande-duchesse de Luxembourg, estrade située place du marché, cérémonie de remise de la croix d'honneur à la ville] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58025

15/2/20, M. Poincaré à Thionville [avec à sa droite la grande-duchesse de Luxembourg, place du marché, défilé de jeunes lorraines en costume, cérémonie de remise de la croix d'honneur à la ville] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58027

16/2/20, M. Poincaré au cimetière de Verdun : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58030

16/2/20, M. Poincaré au cimetière de Verdun : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58031

16/2/20, M. Poincaré à Verdun : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 58033

Induction of CD8 T-cell responses restricted to multiple HLA class I alleles in a cancer patient by immunization with a 20-mer NY-ESO-1f (NY-ESO-1 91-110) peptide.

Immunogenicity of a long 20-mer NY-ESO-1f peptide vaccine was evaluated in a lung cancer patient TK-f01, immunized with the peptide with Picibanil OK-432 and Montanide ISA-51. We showed that internalization of the peptide was necessary to present CD8 T-cell epitopes on APC, contrasting with the direct presentation of the short epitope. CD8 T-cell responses restricted to all five HLA class I alleles were induced in the patient after the peptide vaccination. Clonal analysis showed that B*35:01 and B*52:01-restricted CD8 T-cell responses were the two dominant responses. The minimal epitopes recognized by A*24:02, B*35:01, B*52:01 and C*12:02-restricted CD8 T-cell clones were defined and peptide/HLA tetramers were produced. NY-ESO-1 91-101 on A*24:02, NY-ESO-1 92-102 on B*35:01, NY-ESO-1 96-104 on B*52:01 and NY-ESO-1 96-104 on C*12:02 were new epitopes first defined in this study. Identification of the A*24:02 epitope is highly relevant for studying the Japanese population because of its high expression frequency (60%). High affinity CD8 T-cells recognizing tumor cells naturally expressing the epitopes and matched HLA were induced at a significant level. The findings suggest the usefulness of a long 20-mer NY-ESO-1f peptide harboring multiple CD8 T-cell epitopes as an NY-ESO-1 vaccine. Characterization of CD8 T-cell responses in immunomonitoring using peptide/HLA tetramers revealed that multiple CD8 T-cell responses comprised the dominant response.

Iowa Board of Parole Annual Report for State Fiscal Year 2008 (July 1, 2007 – June 30, 2008), January 20, 2009

Annual report produced by Iowa Board of Parole

Ag Decision Maker, January 2016, Vol. 20, no. 3

A Business Newsletter for Agriculture

Ag Decision Maker, March 2016, Vol. 20, no. 5

A Business Newsletter for Agriculture

Ag Decision Maker, April 2016, Vol. 20, no. 6

A Business Newsletter for Agriculture

A Progress Report on Treating Loess, Fine Sands and Soft Limestones with Liquid Binders, HR-20, 1954

Certain areas of Iowa abound in loess, others contain soft limestones that are readily and cheaply available, and a large portion of the state is underlaid with sand. None of these materials is considered suitable in present practices for use in all-weather road construction. The loess is too fine and too difficult to handle; the limestones are considered too soft, and some of the harder ones unsound for this use; the sands are not naturally of the desired gradation and do not lend themselves to blending into satisfactory gradations. The purpose of this project is, therefore, to study and develop means and to determine the feasibility of using these materials, loess, fine sand, and soft limestones, either separately or in combinations in conjunction with liquid binders to produce paving mixtures applicable for all-weather road construction. Also included in the project was the development of methods of processing any of these materials, if necessary, to make them suitable for the desired purpose