8-2-20, rugby Parc des Princes, [équipe] S.C.U.F. : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57916

Tetrasomy 8 in a patient with acute nonlymphocytic leukemia: a metaphase and interphase study with fluorescence in situ hybridization.

Tetrasomy 8 constitutes a relatively rare recurring chromosome defect in myeloid disorders. The patient reported here, a 71-year-old man, presented with tetrasomy 8 as the sole chromosome abnormality associated with an acute nonlymphocytic leukemia of the M2 type. He failed to respond to chemotherapy and died one year after diagnosis. Following conventional cytogenetics and fluorescence in situ hybridization (FISH) with a centromeric probe specific for chromosome 8, tetrasomy 8 was detected in 61% of the metaphases analyzed and trisomy 8 in 39%. FISH analysis of interphase nuclei confirmed the existence of tetrasomic (35%) and trisomic cells (56%) and revealed a number of cells with two chromosomes 8 (8%). This normal population may represent lymphocytes or myeloid cells that escaped conventional analysis due to their inability to divide or to the small number of metaphases available. The relatively higher proportion of tetrasomic cells in metaphase compared with interphase may be attributed to a proliferative advantage of tetrasomic cells in vitro or to the longer duration of their cell cycle. The simultaneous presence of trisomic and tetrasomic cells confirms the hypothesis of a clonal relationship between trisomy 8 and tetrasomy 8. Our case brings further evidence to the specificity of tetrasomy 8 to myeloid disorders and to the association of this chromosome abnormality with a relatively poor prognosis. However, new patients must be studied to further delineate this cytogenetic entity.

Le Hood [HMS Hood de la Royal Navy] le plus gros navire du monde, 41200 tonnes, 144000 cv, 8 canons de 15 pouces : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57767

8-12-19, retour de Carpentier à Paris : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57184

8-2-20, rugby, Parc des Princes, [équipe du] Boucau [stade] contre [équipe du] Stade français : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57925

8-2-20, rugby, Parc des Princes, [équipe du] Boucau [stade] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57922

S.C.U.F. contre [C.A. Société] Générale, 8-2-20, Parc des Princes, rugby : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57921

S.C.U.F., [C.A. Société] Générale, 8-2-20, rugby, Parc des Princes : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57920

[8-2-20, stade Elysabeth], Bracquemont [footballeuse de l'équipe d'] (En avant), Guéry [de l'équipe d'] (Académia) : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57903

8-2-20, rugby, Parc des Princes, [équipe du] Stade français : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57923

8-2-20, rugby Parc des Princes, [équipe] C.A. Société Générale : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57915

8-12-19 Dodat, député de l'Allier [présent à la première séance de la nouvelle chambre] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 57181

Lottery Action, March 8-21, 2004, Vol. 11, no. 5

Iowa Lottery Authority Retailer Information Newsletter

Lottery Action, April 19-22, 2004, Vol. 11, no. 8

Iowa Lottery Authority Retailer Information Newsletter