(Table 1) Abundance of diagenetic carbonate nodules in bottom sediments from the Gulf of California at Station DM9-666

New data on phosphorites collected by dredging and trawling at depths from 2700 to 520 m in the open Atlantic Ocean (i.e. outside of the shelf and the continental slope) are reported. Aphanitic, granular, brecciated, and conglomerate-like types are distinguished among the phosphorites. A comparison of the studied phosphorites with ones from the Atlantic shelf of Africa and from seamounts of other oceans is made.

Vertical profiles of environmental parameters measured on discrete water samples collected with Niskin bottles during the Tara Oceans expedition 2009-2013

The present data publication provides permanent links to original and updated versions of validated data files. The data files include properties of seawater, particulate matter and dissolved matter that were measured from discrete water samples collected with Niskin bottles during the 2009-2013 Tara Oceans expedition. Properties include pigment concentrations from HPLC analysis (10 depths per vertical profile, 25 pigments per depth), the carbonate system (Surface and 400m; pH (total scale), CO2, pCO2, fCO2, HCO3, CO3, Total alkalinity, Total carbon, OmegaAragonite, OmegaCalcite, and dosage Flags), nutrients (10 depths per vertical profile; NO2, PO4, N02/NO3, SI, quality Flags), DOC, CDOM, and dissolved oxygen isotopes. The Service National d'Analyse des Paramètres Océaniques du CO2, at the Université Pierre et Marie Curie, determined CT and AT potentiometrically (Edmond 1970; DOE 1994) on samples preserved according to Dickson et al. (2007). More than 250 vertical profiles of these properties were made across the world ocean. DOC, CDOM and dissolved oxygen isotopes are available only for the Arctic Ocean and Arctic Seas (2013).

Suite du Répertoire du Théâtre Français, avec un choix des pièces de plusiers autres théâtres, arrangées et mises en ordre

The third of a series of collections of French drama, the first two being the Répertoire général du Théâtre Français, 67 v., 1818; the 4th Collection des théâtres français. Fin du Répertoire, 45 v., 1829; and the 5th Chefs-d'oeuvres du répertoire des melodrames, 20 v., 1824.

İlhan :

At head of title: Kafkas yolu hatırası.

Risk assessment methodology for fast breeder reactors /

"ANL/RAS 75-35."

Taʾrīkh-i Rāshid.

Continuation of Naʻīmā's history, covering the years 1660-1721, with the continuation of Ismāʻīl ʻĀṣim in v.4, covering the years 1721-1728.

Mediterranean pilot.

v. 3. The southeast of Italy, the shores of the Adriatic and Ionian Seas to Cape Matapan -- v. 4. From Cape Matapan (Greece) eastward, the Mediterranean archepelago, and the southern shore of the Mediterranean Sea, eastward to Ras Asjdir(Libia).

Wolf Run, Bluffs, Illinois : strategic planning study : Scott County, Illinois.

"IDNR/OWR/SPS/07-001"

Milaraspa: tibetische Texte in Auswahl übertragen von Berthold Laufer.

Mode of access: Internet.

Le fort d'arrêt "Roupel" : une réponse au général Sarrail /

One folded map in pocket.

Para una política universitaria de recuperación de las memorias de luchas por los valores democráticos y la justicia social

Esta ponencia expondrá la reflexión teórica y metodológica sobre la memoria y los procesos de recuperación de memorias sociales de etapas dictatoriales o represivas, producidas en diferentes actividades de investigación, formación, asistencia técnica, transferencia y divulgación social y científica, hechas desde la Universidad de Barcelona y con diferentes actores sociales (como asociaciones, entidades memorialísticas, espacios socioeducativos de gente mayor y o investigadores/ras universitarios/as) de América latina y España. Para esta tarea, se realizan un conjunto de acciones que se relacionan y retroalimentan de forma permanente, y que se encuentran organizadas y desarrolladas en tres programas marcos: a) "Comunidad y Memoria". Programa de extensión universitaria para la recuperación de las memorias sociales, con entidades de la sociedad civil. b) "Hacer presente la memoria". Programa de investigación y divulgación para hacer presentes las vivencias, las trayectorias y las experiencias de los protagonistas de procesos dictatoriales, con la participación y el testimonio de gente mayor. c) "Razonando la Memoria". Programa de formación y análisis crítico de les metodologías y los debates sobre la memoria, con las universidades y centros científicos y sociales.Se pretende así, acercar la universidad a la sociedad y potenciar la transferencia de conocimientos y tecnologías sociales de especialistas en procesos de recuperación de la memoria para el cumplimiento de los derechos humanos, procedentes de diferentes disciplinas sociales. Asimismo, se pretende asumir con plenitud el irrenunciable compromiso y servicio social que como investigadores/as de nuestro tiempo le debemos a la sociedad a la que pertenecemos, incidiendo en la recuperación de las luchas por los valores democráticos y la justicia social

The renin-angiotensin system and male reproduction: new functions for old hormones

The blood-borne renin-angiotensin system (RAS) is known best for its role in the maintenance of blood pressure and electrolyte and fluid homeostasis. However, numerous tissues show intrinsic angiotensin-generating systems that cater for specific local needs through actions that add to, or differ from, the circulating RAS. The male reproductive system has several sites of intrinsic RAS activity. Recent focus on the epididymis, by our laboratories and by others, has contributed important details about the local RAS in this tissue. The RAS components have been localized morphologically and topographically; they have been shown to be responsive to androgens and to hypoxia; and angiotensin has been shown to influence tubular, and consequently, fluid secretion. Components of the RAS have also been found in the testis, vas deferens, prostate and semen. Angiotensin II receptors, type 1 and, to a lesser extent, type 2 are widespread, and angiotensin IV receptors have been localized in the prostate. The roles of the RAS in local processes at these sites are still uncertain and have yet to be fully elucidated, although there is evidence for involvement in tubular contractility, spermatogenesis, sperm maturation, capacitation, acrosomal exocytosis and fertilization. Notwithstanding this evidence for the involvement of the RAS in various important aspects of male reproduction, there has so far been a lack of clinical evidence, demonstrable by changes in fertility, for a crucial role of the RAS in male reproduction. However, it is clear that there are several potential targets for manipulating the activity of the male reproductive system by interfering with the locally generated angiotensin systems.

Association of stomatin with lipid bodies

The oligomeric lipid raft-associated integral protein stomatin normally localizes to the plasma membrane and the late endosomal compartment. Similar to the caveolins, it is targeted to lipid bodies (LBs) on overexpression. Endogenous stomatin also associates with LBs to a small extent. Green fluorescent protein-tagged stomatin (StomGFP) and the dominant-negative caveolin-3 mutant DGV(cav3)(HA) occupy distinct domains on LB surfaces but eventually intermix. Studies of StomGFP deletion mutants reveal that the region for membrane association but not oligomerization and raft association is essential for LB targeting. Blocking protein synthesis leads to the redistribution of StomGFP from LBs to LysoTracker-positive vesicles indicating a connection with the late endosomal/ lysosomal pathway. Live microscopy of StomGFP reveals multiple interactions between LBs and microtubule-associated vesicles possibly representing signaling events and/or the exchange of cargo. Proteomic analysis of isolated LBs identifies adipophilin and TIP47, various lipid-specific enzymes, cytoskeletal components, chaperones, Ras-related proteins, protein kinase D2, and other regulatory proteins. The association of the Rab proteins 1, 6, 7, 10, and 18 with LBs indicates various connections to other compartments. Our data suggest that LBs are not only involved in the storage of lipids but also participate actively in the cellular signaling network and the homeostasis of lipids.

Anlaysis of complementary expression profiles following WT1 induction versus repression reveals the cholesterol/fatty acid synthetic pathways as a possible major target of WT1

The Wilms' tumour suppressor gene, WT1, encodes a zinc-finger protein that is mutated in Wilms' tumours and other malignancies. WT1 is one of the earliest genes expressed during kidney development. WT1 proteins can activate and repress putative target genes in vitro, although the in vivo relevance of such target genes often remains unverified. To better understand the role of WT1 in tumorigenesis and kidney development, we need to identify downstream target genes. In this study, we have expression pro. led human embryonic kidney 293 cells stably transfected to allow inducible WT1 expression and mouse mesonephric M15 cells transfected with a WT1 antisense construct to abolish endogenous expression of all WT1 isoforms to identify WT1-responsive genes. The complementary overlap between the two cell lines revealed a pronounced repression of genes involved in cholesterol biosynthesis by WT1. This pathway is transcriptionally regulated by the sterol responsive element-binding proteins (SREBPs). Here, we provide evidence that the C-terminal end of the WT1 protein can directly interact with SREBP, suggesting that WT1 may modify the transcriptional function of SREBPs via a direct protein-protein interaction. Therefore, the tumour suppressor activities of WT1 may be achieved by repressing the mevalonate pathway, thereby controlling cellular proliferation and promoting terminal differentiation.