Medial and lateral hamstrings and quadriceps co-activation affects knee joint kinematics and ACL elongation : a pilot study

EL MENSAJE DE LA ECONOMIA POLITICA RADICAL

La economía se presenta a menudo como la ciencia social más madura y exacta, capaz de orientar acciones, realizar pronósticos, explicar el pasado. Todo ello de una manera, si no impecable, sí satisfactoria a grandes rasgos. Ya lo dijo Popper de manera poco cautelosa: "El éxito de la Economía Matemática muestra que por lo menos una ciencia social ha pasado por su revolución newtoniana" (Popper, 1957, 74). También goza la economía de buenas referencias en lo que atañe a su genealogía y tradición intelectual: algunas de sus máximas tienen un respetable pedigrí de más de dos siglos. Por otra parte, sus argumentaciones más preciadas suelen presentarse en la alta sociedad académica vestidas con formalismos matemáticos aparatosos, cuando no espectaculares. A primera vista parece, pues, hallarse en un estado muy saludable, bien orientada en cuanto a bases y perspectivas. Luego no es de extrañar que sea motivo de envidia y de imitación por parte de investigadores de campos vecinos que también aspiran a entender cómo funcionan los seres humanos en sociedad.El resultado final es un texto un tanto híbrido, a medio camino entre el ensayo de divulgación y las notas de clase. De todos modos, aunque sus objetivos sean modestos en lo que se refiere a rigor y originalidad, confío en que cumpla en alguna medida el cometido asignado, a saber, sugerir e incluso provocar. Deseo puntualizar, por último, que algunas de las ideas aquí expuestas se hallan argumentadas de forma más sistemática y cuidada en el artículo "Teoría económica y enfoque de la reproducción" (in Febrero, ed., Qué es la economía, Madrid, Pirámide, 1997, págs. 241-269), así como en mis libros Filosofía de la economía (Barcelona, Icaria, 1992) y Economía política radical (Madrid, Síntesis, 1998).

Iniltration vs. instillation of ropivacaine 7.5% in radical mastectomies for postoperative analgesia

Objective: Determining the effectiveness of iniltration versus instillation with 7.5% ropivacaine in reducing the intensity of postoperative pain in patients undergoing a radical mastectomy. Material and methods: Clinical, prospective, and comparative analytical study in a sample of 20 female patients between 20 and 60 years of age, ASA I and II, weight 50-90 kg, who were divided into 2 groups (10 patients each). In Group 1 infiltration with ropivacaine 7.5% (20 ml) was applied prior to closure of the surgical wound, meanwhile in Group 2 ropivacaine 7.5% (20 ml), was instilled into the surgical wound. P ain intensity was assessed by a visual analog scale (V AS) upon extubation. The need for rescue medication and the incidence of nausea and vomiting were measured from 0 to 30 minutes postoperatively and at 2, 4, 8 and 12 hours. Results: There was no statistical difference between the groups (only the group managed through iniltration required rescue medications), but the iniltration group had a lower perception of pain. Conclusions: This study reported the same eficacy of preventive treatment of postoperative pain in patients who underwent radical mastectomy for instillation and iniltration with 7.5% ropivacaine and little need for rescue medication postoperatively.

Manifiesto inflexivo: 10 ideas para construir una cultura radical de paz y derechos humanos

Imaginar una cultura radical de paz y de derechos humanos pasa por el descubrimiento de las fisuras, de las quiebras y de las ambigüedades del proyecto conservador hegemónico. Ello permite, primero, denunciar su naturaleza contradictoria; y segundo, irrumpir en lo real refundando una política de transformación y de emancipación. En la actualidad, se vive y se produce bajo un proceso de subsunción “global” del hacer humano en el modelo de relaciones impuesto por la globalización neoliberal. Todo puede ser explotado. Las  fronteras de la cumulación se extienden hasta tragarse el lenguaje, los afectos, los cerebros, la capacidad de cooperación, la actividad de cuidado, el uso y el conocimiento de nuevas (y viejas) tecnologías e incluso, el propio saber tradicional de pueblos históricamente marginados y explotados. La producción se confunde hoy con la actividad social. Pero, aunque la forma salarial siga dominado como forma arbitraria de dominación, la actividad social en su plenitud excede con mucho lo que se paga por su puesta en práctica.

Ab Initio Quantum Chemical Studies on Neutral-Radical Reactions of Ethynyl (C2H) and Cyano (CN) with Unsaturated Hydrocarbons

An Ab Initio/RRKM study of the reaction mechanism and product branching ratios of neutral-radical ethynyl (C2H) and cyano (CN) radical species with unsaturated hydrocarbons is performed. The reactions studied apply to cold conditions such as planetary atmospheres including Titan, the Interstellar Medium (ISM), icy bodies and molecular clouds. The reactions of C2H and CN additions to gaseous unsaturated hydrocarbons are an active area of study. NASA’s Cassini/Huygens mission found a high concentration of C2H and CN from photolysis of ethyne (C2H2) and hydrogen cyanide (HCN), respectively, in the organic haze layers of the atmosphere of Titan. The reactions involved in the atmospheric chemistry of Titan lead to a vast array of larger, more complex intermediates and products and may also serve as a chemical model of Earth’s primordial atmospheric conditions. The C2H and CN additions are rapid and exothermic, and often occur barrierlessly to various carbon sites of unsaturated hydrocarbons. The reaction mechanism is proposed on the basis of the resulting potential energy surface (PES) that includes all the possible intermediates and transition states that can occur, and all the products that lie on the surface. The B3LYP/6-311g(d,p) level of theory is employed to determine optimized electronic structures, moments of inertia, vibrational frequencies, and zero-point energy. They are followed by single point higher-level CCSD(T)/cc-vtz calculations, including extrapolations to complete basis sets (CBS) of the reactants and products. A microcanonical RRKM study predicts single-collision (zero-pressure limit) rate constants of all reaction paths on the potential energy surface, which is then used to compute the branching ratios of the products that result. These theoretical calculations are conducted either jointly or in parallel to experimental work to elucidate the chemical composition of Titan’s atmosphere, the ISM, and cold celestial bodies.

Short-term and long-term changes in corneal power are not correlated with axial elongation of the eye induced by orthokeratology in children

PURPOSE: To assess the relationship between short-term and long-term changes in power at different corneal locations relative to the change in central corneal power and the 2-year change in axial elongation relative to baseline in children fitted with orthokeratology contact lenses (OK). METHODS: Thirty-one white European subjects 6 to 12 years of age and with myopia −0.75 to −4.00 DS and astigmatism ≤1.00 DC were fitted with OK. Differences in refractive power 3 and 24 months post-OK in comparison with baseline and relative to the change in central corneal power were determined from corneal topography data in eight different corneal regions (i.e., N[nasal]1, N2, T[temporal]1, T2, I[inferior]1, I2, S[superior]1, S2), and correlated with OK-induced axial length changes at two years relative to baseline. RESULTS: After 2 years of OK lens wear, axial length increased by 0.48±0.18 mm (P0.05). CONCLUSION: The reduction in central corneal power and relative increase in paracentral and pericentral power induced by OK over 2 years were not significantly correlated with concurrent changes in axial length of white European children.

Evaluation of tumor recurrences after radical prostatectomy using 18F-Choline PET/CT and 3T multiparametric MRI without endorectal coil: a single center experience

The aim os this study is to evaluate and compare the utility of 18F-fluorocholine (18F-CH) PET/CT versus 3-Tesla multiparametric MRI (mpMRI) without endorectal coil to detect tumor recurrences in patients with biochemical relapse following radical prostatectomy (RP). Secondarily, to identify possible prognostic variables associated with mpMRI and 18F-CH PET/CT findings. Retrospective study of 38 patients who developed biochemical recurrence after RP between the years 2011 and 2015 at our institution. PET/CT and mpMRI were both performed within 30 days of each other in all patients. The PET/CT was reviewed by a nuclear medicine specialist while the mpMRI was assessed by a radiologist, both of whom were blinded to outcomes. The median prostate-specific antigen (PSA) value pre-MRI/PET-CT was 0.9 ng/mL (interquartile range 0.4–2.2 ng/mL). There were no differences in the detection rate between 18F-CH PET/CT and mpMRI for local recurrence (LR), lymph node recurrence (LNR) and bone metastases (BM). Separately, mpMRI and 18F-CH PET/CT were positive for recurrence in 55.2% and 52.6% of cases, respectively, and in 65.7% of cases when findings from both modalities were considered together. The detection of LR was better with combined mpMRI and choline PET/CT versus choline PET/CT alone (34.2% vs 18.4%, p = 0.04). Salvage treatment was modified in 22 patients (57.8%) based on the imaging findings. PSA values on the day of biochemical failure were significantly associated with mpMRI positivity (adjusted odds ratio (OR): 30.9; 95% confidence interval (CI): 1.5–635.8). Gleason score > 7 was significantly associated with PET/CT positivity (OR: 13.9; 95% CI: 1.5–125.6). A significant association was found between PSA doubling time (PSADT) (OR: 1.3; 95% CI: 1.0–1.7), T stage (OR: 21.1; 95% CI: 1.6–272.1), and LR. Multiparametric MRI and 18F-CH PET/CT yield similar detection rates for LR, LNR and pelvic BM. The combination of both imaging techniques provides a better LR detection versus choline PET/CT alone. The initially planned salvage treatment was modified in 57.8% of patients due to imaging findings. In addition to PSA values, Gleason score, T stage, and PSADT may provide valuable data to identify those patients that are most likely to benefit from undergoing both imaging procedures.