Differential migration of in vivo primed B and T lymphocytes to lymphoid and non-lymphoid organs.

Our study describes tissue-specific migration of T and B cells during a localized anti-viral immune response. After mouse mammary tumor virus (MMTV) injection, B lymphocytes of the draining lymph node become infected and present a retroviral superantigen to CD4(+) T lymphocytes. Infected B cells receive superantigen-mediated help in a fashion comparable to classical immune responses. To investigate the fate of T and B lymphocytes that had interacted via cognate help in the same peripheral lymph node microenvironment we adoptively transferred them into naive recipients. Here we show that MMTV-infected B cells and superantigen-stimulated T cells were programmed to migrate to distinct sites of the body. Plasmablasts but not T cells migrated to the mammary gland and activated alpha4beta1 integrins were found to have a crucial role in the migration to the mammary gland. In contrast, T cells had a much higher affinity for secondary lymphoid organs and large intestine. This demonstrates that upon antigen-driven B and T lymphocyte interaction in the local draining lymph node a subset-specific homing program for B and T lymphocytes is induced.

A-1 Monthly Public Assistance Statistical Report Family Investment Program, January 2004

Monthly Public Assistance Statistical Report Family Investment Program

F-1, Food Stamp Program - State Summary, February 2004

The Food Assistance Monthly Participation Report is a monthly summary of Food Assistance program participation, Statewide and for each Iowa county. Breakouts are reported for participants also in the FIP program, those only receiving Food Assistance, and those that are receiving economic assistance under other programs (primarily Medicaid). This report may also be known as the F-1 Report.

A-1A Supplemental Security Income Program, February 2004

Monthly report from Iowa Department of Human Services on income.

A-1 Monthly Public Assistance Statistical Report Family Investment Program, February 2004

Monthly Public Assistance Statistical Report Family Investment Program

A-1A Supplemental Security Income Program, March 2004

Monthly report from the Iowa Department of Human Services on Supplemental Security Income Program (SSI).

F-1, Food Assistance Program - State Summary, April 2004

The Food Assistance Monthly Participation Report is a monthly summary of Food Assistance program participation, Statewide and for each Iowa county. Breakouts are reported for participants also in the FIP program, those only receiving Food Assistance, and those that are receiving economic assistance under other programs (primarily Medicaid). This report may also be known as the F-1 Report.

Annual Report for the Iowa Highway Safety Program, Federal Fiscal Year 2003

Annual Highway Safety Evaluation Report for the Governor's Traffic Safety Bureau, Iowa Department of Public Safety

Annual Report for the Iowa Highway Safety Program, 2000

Annual Highway Safety Evaluation Report for the Governor's Traffic Safety Bureau, Iowa Department of Public Safety

A-1 Monthly Public Assistance Statistical Report Family Investment Program, March 2004

Monthly Public Assistance Statistical Report Family Investment Program

Iowa New Jobs Training Program Annual Report, 2003

Annual Report

A-1A Supplemental Security Income Program, April 2004

Monthly report from the Iowa Department of Human Services on income.

Educational Excellence Program for Fiscal Years 1999 - 2002

A Review of the Educational Excellence Program for Fiscal Years 1999 - 2002 and the Student Achievement and Teacher Quality Program for Fiscal Year 2002 within the Department of Education

A-1 Monthly Public Assistance Statistical Report Family Investment Program, April 2004

Monthly Public Assistance Statistical Report Family Investment Program

A-1A Supplemental Security Income Program, May 2004

Monthly report from Iowa Department of Human Services on income.