Louis II de Bavière / Jacques Bainville

Collection : Hier et aujourd'hui

Mundo común, feminismo y mitología

[spa]Desde la década de 1970 el feminismo ha significado una de las profundizaciones críticas m.s productivas del legado del pensamiento político de la modernidad. El presente artículo atiende al cuestionamiento de las modernas nociones de libertad y comunidad políticas que Linda Zerilli ha llevado a cabo en su lectura de Hannah Arendt y de Ludwig Wittgenstein. A partir de ah. y de la reciente querella en torno al diformismo sexual, se muestra la necesidad de repensar la relación entre teoría y praxis más allá de la concepción moderna, presente en buena parte de la teoría feminista contemporánea. [eng]Since the 1970s feminism has signified one of the most productive critical reconsiderations of modern political thought legacy. This article examines the questioning ofmodern notions of political freedom and political community that Linda Zerilli has undertaken in her reading of Hannah Arendt and Ludwig Wittgenstein. On this basis and on criticism of sexual dimorphism, the article shows the need to rethink the relationship between theory and praxis beyond itsmodern conception, a feature present in much of contemporary feminist theory.

Superiority of the Triple Combination of Bortezomib-Thalidomide-Dexamethasone Over the Dual Combination of Thalidomide-Dexamethasone in Patients With Multiple Myeloma Progressing or Relapsing After Autologous Transplantation: The MMVAR/IFM 2005-04 Randomized Phase III Trial From the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation.

PURPOSE This prospective multicenter phase III study compared the efficacy and safety of a triple combination (bortezomib-thalidomide-dexamethasone [VTD]) versus a dual combination (thalidomide-dexamethasone [TD]) in patients with multiple myeloma (MM) progressing or relapsing after autologous stem-cell transplantation (ASCT). PATIENTS AND METHODS Overall, 269 patients were randomly assigned to receive bortezomib (1.3 mg/m(2) intravenous bolus) or no bortezomib for 1 year, in combination with thalidomide (200 mg per day orally) and dexamethasone (40 mg orally once a day on 4 days once every 3 weeks). Bortezomib was administered on days 1, 4, 8, and 11 with a 10-day rest period (day 12 to day 21) for eight cycles (6 months), and then on days 1, 8, 15, and 22 with a 20-day rest period (day 23 to day 42) for four cycles (6 months). Results Median time to progression (primary end point) was significantly longer with VTD than TD (19.5 v 13.8 months; hazard ratio, 0.59; 95% CI, 0.44 to 0.80; P = .001), the complete response plus near-complete response rate was higher (45% v 25%; P = .001), and the median duration of response was longer (17.2 v 13.4 months; P = .03). The 24-month survival rate was in favor of VTD (71% v 65%; P = .093). Grade 3 peripheral neuropathy was more frequent with VTD (29% v 12%; P = .001) as were the rates of grades 3 and 4 infection and thrombocytopenia. CONCLUSION VTD was more effective than TD in the treatment of patients with MM with progressive or relapsing disease post-ASCT but was associated with a higher incidence of grade 3 neurotoxicity.

Bild des Verfassers

Muotokuvassa Monrepos'n kartanon omistaja, runoilija Ludwig Heinrich von Nicolay (1737-1820).

Die Quelle Sylmia

Sylmian lähde metsän ja kallioiden keskellä Montrepos'n puistossa. Lähteen ympärillä on katos ja rauta-aita, vesi valuu etualalla olevaan pyöreään kivialtaaseen

Das Pampuschinka

Pampuschinka, Monrepos¿n puiston kallioinen ja louhikkoinen alue. Korkean kallion päällä valtava kivenjärkäle.

Garten-Anlagen

Monrepos¿n puiston puutarha, kukkaistutuksia, pieni kaarisilta; taustalla Paulstein.