982 resultados para Sensory-motor integration
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Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.
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Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.
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Spondyloepimetaphyseal dysplasia with joint laxity, leptodactylic type (lepto-SEMDJL, aka SEMDJL, Hall type), is an autosomal dominant skeletal disorder that, in spite of being relatively common among skeletal dysplasias, has eluded molecular elucidation so far. We used whole-exome sequencing of five unrelated individuals with lepto-SEMDJL to identify mutations in KIF22 as the cause of this skeletal condition. Missense mutations affecting one of two adjacent amino acids in the motor domain of KIF22 were present in 20 familial cases from eight families and in 12 other sporadic cases. The skeletal and connective tissue phenotype produced by these specific mutations point to functions of KIF22 beyond those previously ascribed functions involving chromosome segregation. Although we have found Kif22 to be strongly upregulated at the growth plate, the precise pathogenetic mechanisms remain to be elucidated.
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Evidence of multisensory interactions within low-level cortices and at early post-stimulus latencies has prompted a paradigm shift in conceptualizations of sensory organization. However, the mechanisms of these interactions and their link to behavior remain largely unknown. One behaviorally salient stimulus is a rapidly approaching (looming) object, which can indicate potential threats. Based on findings from humans and nonhuman primates suggesting there to be selective multisensory (auditory-visual) integration of looming signals, we tested whether looming sounds would selectively modulate the excitability of visual cortex. We combined transcranial magnetic stimulation (TMS) over the occipital pole and psychophysics for "neurometric" and psychometric assays of changes in low-level visual cortex excitability (i.e., phosphene induction) and perception, respectively. Across three experiments we show that structured looming sounds considerably enhance visual cortex excitability relative to other sound categories and white-noise controls. The time course of this effect showed that modulation of visual cortex excitability started to differ between looming and stationary sounds for sound portions of very short duration (80 ms) that were significantly below (by 35 ms) perceptual discrimination threshold. Visual perceptions are thus rapidly and efficiently boosted by sounds through early, preperceptual and stimulus-selective modulation of neuronal excitability within low-level visual cortex.
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Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.
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Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.
Resumo:
Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.
Resumo:
Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.
Resumo:
Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.
Resumo:
Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.
Resumo:
Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.
Resumo:
Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.
Resumo:
Record of the Fatalities for Motor Vehicle Accidents in Iowa per week.
