Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance

Abstract Alteration of the surface glycosylation pattern on malignant cells potentially affects tumor immunity by directly influencing interactions with glycan-binding proteins (lectins) on the surface of immunomodulatory cells. The sialic acid-binding Ig-like lectins Siglec-7 and -9 are MHC class I-independent inhibitory receptors on human NK cells that recognize sialic acid-containing carbohydrates. Here, we found that the presence of Siglec-9 defined a subset of cytotoxic NK cells with a mature phenotype and enhanced chemotactic potential. Interestingly, this Siglec-9+ NK cell population was reduced in the peripheral blood of cancer patients. Broad analysis of primary tumor samples revealed that ligands of Siglec-7 and -9 were expressed on human cancer cells of different histological types. Expression of Siglec-7 and -9 ligands was associated with susceptibility of NK cell-sensitive tumor cells and, unexpectedly, of presumably NK cell-resistant tumor cells to NK cell-mediated cytotoxicity. Together, these observations have direct implications for NK cell-based therapies and highlight the requirement to consider both MHC class I haplotype and tumor-specific glycosylation.

Verslag, uitgebragt in de een-en twintigste openbare vergadering van het Nederlandsch-Israelietisch armbestuur te Amsterdam ... den 17den September 1856

door S. E. Nykerk

Jacob Abraham und Abraham Abramson : 55 Jahre Berliner Medaillenkunst 1755 - 1810

von Tassilo Hoffmann

David Deutsch (1810-73), ein Rabbiner in Myslowitz u. Sohrau O.-S. : ein Lebensbild

von J. Norden. Hrsg. vom "Verein f. jüd. Geschichte u. Litteratur"

Zakarti : Zum Gedenken an Robert Kaelter, Rabbiner der Synagogengemeinde Danzig

[Vorr.: Ruth Ollendorff]

Sir Robert ergreift die dargereichte Bruderhand...

Bibliograph. Nachweis: Wolf, Sylvia: Politische Karikaturen in Deutschland 1848/49. Mittenwald 1982. – 1. 27 Nr. 8