The position of a social economy in the Czech Republic at present

The Social Economy is a new phenomenon in the Czech Republic. It means the economy with its social effects that is being supported within public politics. Some analyses have been done at J.E:purkynI University in Ústí nad Labem during the last years. The topics of this research were the transformation of public administration, non-profit sector(respectively the civil mix sector), co-operatives, and social enterprises, and it is still ongoing.

Sensitivity map of laser tweezers Raman spectroscopy for single-cell analysis of colorectal cancer

Raman spectroscopy on single, living epithelial cells captured in a laser trap is shown to have diagnostic power over colorectal cancer. This new single-cell technology comprises three major components: primary culture processing of human tissue samples to produce single-cell suspensions, Raman detection on singly trapped cells, and diagnoses of the cells by artificial neural network classifications. it is compared with DNA flow cytometry for similarities and differences. Its advantages over tissue Raman spectroscopy are also discussed. In the actual construction of a diagnostic model for colorectal cancer, real patient data were taken to generate a training set of 320 Raman spectra and, a test set of 80. By incorporating outlier corrections to a conventional binary neural classifier, our network accomplished significantly better predictions than logistic regressions, with sensitivity improved from 77.5% to 86.3% and specificity improved from 81.3% to 86.3% for the training set and moderate improvements for the test set. Most important, the network approach enables a sensitivity map analysis to quantitate the relevance of each Raman band to the normal-to-cancer transform at the cell level. Our technique has direct clinic applications for diagnosing cancers and basic science potential in the study of cell dynamics of carcinogenesis. (C) 2007 Society of Photo-Optical Instrumentation Engineers.

Silenced angels: an obscure Saint Theresa in George Eliots Middlemarch

A presente dissertação objetiva a comparação proposta no Prelúdio do romance Middlemarch por sua autora George Eliot entre a protagonista da obra, Dorothea Brooke, e a figura histórica Teresa dÁvila. A partir de tal estudo, busca-se compreender de que modo a situação específica da mulher na Era Vitoriana é articulada no romance de modo a espelhar a crise ontológica e epistemológica do próprio ser humano diante das transformações consolidadas com o Iluminismo e as revoluções liberais do século XVIII que culminariam na morte de Deus. Dorothea mostra-se uma cristã tão fervorosa quanto a Teresa quinhentista, mas faltam-lhe certezas e a resolução para concretizar as reformas sociais que defende, pois ela encarna o mito de feminilidade oitocentista batizado de Anjo do Lar ideal de sujeição feminina à ordem falocêntrica cujas funções são a proteção e difusão da moralidade burguesa e a substituição de elementos cristãos no universo do sagrado a uma sociedade cada vez mais materialista e insegura de valores absolutos. As aflições de Dorothea representam as aflições da mulher vitoriana, mas o momento crítico desta mulher reflete, em Middlemarch, uma crise muito maior do Ocidente, que teve início com a Era da Razão

From the Cajal alumni Achucarro and Rio-Hortega to the rediscovery of never-resting microglia

Under the guidance of Ramon y Cajal, a plethora of students flourished and began to apply his silver impregnation methods to study brain cells other than neurons: the neuroglia. In the first decades of the twentieth century, Nicolas Achucarro was one of the first researchers to visualize the brain cells with phagocytic capacity that we know today as microglia. Later, his pupil Pio del Rio-Hortega developed modifications of Achucarro's methods and was able to specifically observe the fine morphological intricacies of microglia. These findings contradicted Cajal's own views on cells that he thought belonged to the same class as oligodendroglia (the so called "third element" of the nervous system), leading to a long-standing discussion. It was only in 1924 that Rio-Hortega's observations prevailed worldwide, thus recognizing microglia as a unique cell type. This late landing in the Neuroscience arena still has repercussions in the twenty first century, as microglia remain one of the least understood cell populations of the healthy brain. For decades, microglia in normal, physiological conditions in the adult brain were considered to be merely "resting," and their contribution as "activated" cells to the neuroinflammatory response in pathological conditions mostly detrimental. It was not until microglia were imaged in real time in the intact brain using two-photon in vivo imaging that the extreme motility of their fine processes was revealed. These findings led to a conceptual revolution in the field: "resting" microglia are constantly surveying the brain parenchyma in normal physiological conditions. Today, following Cajal's school of thought, structural and functional investigations of microglial morphology, dynamics, and relationships with neurons and other glial cells are experiencing a renaissance and we stand at the brink of discovering new roles for these unique immune cells in the healthy brain, an essential step to understand their causal relationship to diseases.