994 resultados para SOFT-PART SARCOMA


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Monitavoiteoptimointia käytetään laajasti auto- ja lentokoneteollisuudessa suunnittelun apu-välineenä, mutta muuten sen käyttö ei ole vielä yleistynyt laajemmin. Tässä työssä on tarkoi-tus tehdä laaja esiselvitys monitavoiteoptimoinnista ja sen hyödyntämisestä työkonepuomien suunnittelun apuvälineenä. Työ tehtiin yhteistyössä Lappeenrannan teknillisen yliopiston ja projektiin osallistuvien FIMA ry:n jäsenten kanssa. Tulosten ja johtopäätösten perusteella tutkimusta tullaan mahdollisesti jatkamaan Tampereen teknillisen yliopiston tohtorikoulussa. Työssä selvitettiin mitä monitavoiteoptimoinnilla tarkoitetaan ja esitellään sen etenemisvai-heet. Lisäksi työssä esitellään lyhyesti kuusi monitavoiteoptimointiohjelmistoa pääominai-suuksineen sekä selvitetään ohjelmistolisenssien hintoja. Työssä optimointiin perehdyttiin teleskooppipuomin jatkoksen case -tutkimuksen avulla. Ni-velpuomit ja nivel- ja teleskooppipuomien yhdistelmät rajattiin työn ulkopuolelle. Työssä muodostettiin teleskooppipuomin jatkoksen poikkileikkauksen optimointityökalu. Sen avulla voidaan laskea luotettavasti optimit mitat painon suhteen niin, että lommahdusrajoitteet, tai-vutusvastus sekä taipuma otetaan huomioon ja samalla voitiin arvioida optimointiprosessin etuja ja haittoja. Optimoinnin tuloksia voidaan käyttää edelleen monitavoiteoptimoinnin lähtö-arvoina. Optimointi tehtiin Matlabin avulla ja tulokset verifioitiin AGIFAP -elementtimenetelmäohjelmistolla. Optimoituja tuloksia tutkittiin edelleen Femap -elementtimenetelmäohjelmistolla, jolla haettiin vuorovaikutussuhteita monitavoiteoptimoinnin tueksi. FE -analyysien avulla muodostettiin kaksi apuohjelmaa optimoinnin tueksi. Työssä havaittiin, että teleskooppipuomin jatkoksen optimointi vaatii FE -analyysiohjelmiston rinnalleen, jotta voidaan varmistua rakenteen kestävyydestä ja optimoida väsymiskestävyyt-tä. Liukupalojen vaikutus teleskooppipuomin käytökseen sekä väsymiskestävyyden optimoin-ti vaatii jatkotutkimusta.

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In this study, I examine the board of directors as a part of family business governance. Both boards and governance have increased their attractiveness as a research topic lately. Research on boards has concentrated mostly on the study of different board attributes, like composition, and the relationship of these attributes to the firm’s performance. Family business governance studies are criticized for ignoring the multifaceted needs of companies. More research observing the context and contingencies affecting the governance and board of directors is needed. The objective of this study is to clarify: 1) how the board participates in family business governance, and 2) how the board develops along with the firm’s and family’s development. The study is implemented as qualitative research, and the longitudinal process approach has been used as it provides the opportunity to examine development in context. Selection criteria for the two cases selected for this study are: active board of directors, at least one implemented succession, and interviewees available from two generations and from different positions in the firm. The data consists of interviews and secondary data, and it is collected from different data sources. The analysis was done selecting first some critical events from both cases to closer examination, and analysing them by using content analysis technique. Several conclusions were drawn basing on the findings. First, the family business board participates in the firm’s activities much more widely than it is customary to think. Second, the family business board is not a static part of the business, but it develops and it has to develop for different reasons. Third, ownership is not only the basis for the board’s activities or existence, but the relationship between the board and ownership is two-way. The board contributes to a large extent to the ownership decisions, and in this way to the management of ownership. Fourth, according to the cases, the board has many unrecognized possibilities to facilitate succession in family firms.

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Kartta kuuluu A. E. Nordenskiöldin kokoelmaan

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Kartta kuuluu A. E. Nordenskiöldin kokoelmaan

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This is a sociological study of the views of officers in the Swedish Army and its Amphibious Forces on tactics in Irregular Warfare (IW), in particular, Counterinsurgency (COIN). IW comprises struggles, where the military weaker part uses an indirect approach with smaller units and integrates the civilian and military dimensions in a violence spectrum including subversion, terrorism, Guerrilla Warfare and infantry actions. IW is the main armed warfare style in insurgencies. COIN is the combined political, military, economic, social and legal actions in counter insurgencies. Data has been collected by means of interviews with almost all (n =43) officers, who were either commanding battalions or rifle and manoeuvre companies while undergoing training for general warfare and international operations. The main theoretical and methodological inspiration is the traditional one for research on social fields, inaugurated by the French sociologist Pierre Bourdieu. The statistical technique used is Multiple Correspondence Analysis. As a background and context base, an inquiry inspired by the Begriffsgechichte (Conceptual History) tradition explores the genesis and development of understandings of the term Irregular Warfare. The research question is outlined as; “how can contemporary Swedish military thought on tactics in Irregular Warfare be characterized using descriptive patterns, mapped in relation to background factors and normative standards? The most significant findings are that there are two main opposing notions separating the officers’ views on tactics in Irregular Warfare: (1) a focus on larger, combat oriented and collectively operating military units versus smaller and larger, more intelligence oriented and dispersed operating units, and (2) a focus on military tasks and kinetic effects versus military and civilian tasks as well as “soft” effects. The distribution of these views can be presented as a two-dimensional space structured by the two axes. This space represents four categories of tactics, partly diverging from normative military standards for Counterinsurgency. This social space of standpoints shows different structural tendencies for background factors of social and cultural character, particularly dominant concerning military backgrounds, international mission experiences and civilian education. Compared to military standards for Counterinsurgency, the two tactical types characterized by a Regular Warfare mind-set stands out as counter-normative. Signs of creative thought on military practice and theory, as well as a still persistent Regular Warfare doxa are apparent. Power struggles might thus develop, effecting the transformation to a broadened warfare culture with an enhanced focus also on Irregular Warfare. The result does not support research results arguing for a convergence of military thought in the European transformation of Armed Forces. The main argument goes beyond tactics and suggests sociological analysis on reciprocal effects regarding strategy, operational art, tactics as well as leadership, concerning the mind-set and preferences for Regular, Irregular and Hybrid Warfare.

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Kartta kuuluu A. E. Nordenskiöldin kokoelmaan

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Kartta kuuluu A. E. Nordenskiöldin kokoelmaan

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With a Sales and Operations Planning (S&OP) process, a company aims to manage the demand and supply by planning and forecasting. The studied company uses an integrated S&OP process to improve the company's operations. The aim of this thesis is to develop this business process by finding the best possible way to manage the soft information in S&OP, whilst also understanding the importance and types (assumptions, risks and opportunities) of soft information in S&OP. The soft information in S&OP helps to refine future S&OP planning, taking into account the uncertainties that affect the balance of the long-term demand and supply (typically 12-18 months). The literature review was used to create a framework for soft information management process in S&OP. There were not found a concrete way how to manage soft information in the existing literature. In consequence of the poor literature available the Knowledge Management literature was used as the base for the framework creation, which was seen in the very same type of information management like the soft information management is. The framework created a four-stage process to manage soft information in S&OP that included also the required support systems. First phase is collecting and acquiring soft information in S&OP, which include also categorization. The categorization was the cornerstone to identify different requirements that needs to be taken into consideration when managing soft information in S&OP process. The next phase focus on storing data, which purpose is to ensure the soft information is managed in a common system (support system) in a way that the following phase makes it available to users in S&OP who need by help of sharing and applications process. The last phase target is to use the soft information to understand assumptions and thoughts of users behind the numbers in S&OP plans. With this soft management process the support system will have a key role. The support system, like S&OP tool, ensures that soft information is stored in the right places, kept up-to-date and relevancy. The soft information management process in S&OP strives to improve the relevant soft information documenting behind the S&OP plans into the S&OP support system. The process offers an opportunity to individuals to review, comment and evaluate soft information in S&OP made by their own or others. In the case company it was noticed that without a properly documented and distributed soft information in S&OP it was seen to cause mistrust towards the planning.

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The aims of the present study were to determine the prevalence of human herpesvirus type 8 (HHV-8) in HIV-positive Brazilian patients with (HIV+/KS+) and without Kaposi's sarcoma (HIV+/KS-) using PCR and immunofluorescence assays, to assess its association with KS disease, to evaluate the performance of these tests in detecting HHV-8 infection, and to investigate the association between anti-HHV-8 antibody titers, CD4 counts and staging of KS disease. Blood samples from 66 patients, 39 HIV+/KS+ and 27 HIV+/KS-, were analyzed for HHV-8 viremia in peripheral blood mononuclear cells by PCR and HHV-8 antigenemia for latent and lytic infection by immunofluorescence assay. Positive samples for latent nuclear HHV-8 antigen (LNA) antibodies were titrated out from 1/100 to 1/409,600 dilution. Clinical information was collected from medical records and risk behavior was assessed through an interview. HHV-8 DNA sequences were detected by PCR in 74.3% of KS+ patients and in 3.7% of KS- patients. Serological assays were similar in detecting anti-LNA antibodies and anti-lytic antigens in sera from KS+ patients (79.5%) and KS- patients (18.5%). HHV-8 was associated with KS whatever the method used, i.e., PCR (odds ratio (OR) = 7.4, 95% confidence interval (CI) = 2.16-25.61) or anti-LNA and anti-lytic antibodies (OR = 17.0, 95%CI = 4.91-59.14). Among KS+ patients, HHV-8 titration levels correlated positively with CD4 counts (rho 0.48, P = 0.02), but not with KS staging. HHV-8 is involved in the development of KS in different geographic areas worldwide, as it is in Brazil, where HHV-8 is more frequent among HIV+ patients. KS severity was associated with immunodeficiency, but no correlation was found between HHV-8 antibody titers and KS staging.

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Kartta kuuluu A. E. Nordenskiöldin kokoelmaan

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Kartta kuuluu A. E. Nordenskiöldin kokoelmaan

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Kartta kuuluu A. E. Nordenskiöldin kokoelmaan