945 resultados para Read, Guy Martin
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LINCOLN UNIVERSITY - On March 25, 1965, a bus loaded with Lincoln University students and staff arrived in Montgomery, Ala. to join the Selma march for racial and voting equality. Although the Civil Rights Act of 1964 was in force, African-Americans continued to feel the effects of segregation. The 1960s was a decade of social unrest and change. In the Deep South, specifically Alabama, racial segregation was a cultural norm resistant to change. Governor George Wallace never concealed his personal viewpoints and political stance of the white majority, declaring “Segregation now, segregation tomorrow, segregation forever.” The march was aimed at obtaining African-Americans their constitutionally protected right to vote. However, Alabama’s deep-rooted culture of racial bias began to be challenged by a shift in American attitudes towards equality. Both black and whites wanted to end discrimination by using passive resistance, a movement utilized by Dr. Martin Luther King Jr. That passive resistance was often met with violence, sometimes at the hands of law enforcement and local citizens. The Selma to Montgomery march was a result of a protest for voting equality. The Student Nonviolent Coordinating Committee (SNCC) and the Southern Christian Leadership Counsel (SCLC) among other students marched along the streets to bring awareness to the voter registration campaign, which was organized to end discrimination in voting based on race. Violent acts of police officers and others were some of the everyday challenges protesters were facing. Forty-one participants from Lincoln University arrived in Montgomery to take part in the 1965 march for equality. Students from Lincoln University’s Journalism 383 class spent part of their 2015 spring semester researching the historical event. Here are their stories: Peter Kellogg “We’ve been watching the television, reading about it in the newspapers,” said Peter Kellogg during a February 2015 telephone interview. “Everyone knew the civil rights movement was going on, and it was important that we give him (Robert Newton) some assistance … and Newton said we needed to get involve and do something,” Kellogg, a lecturer in the 1960s at Lincoln University, discussed how the bus trip originated. “That’s why the bus happened,” Kellogg said. “Because of what he (Newton) did - that’s why Lincoln students went and participated.” “People were excited and the people along the sidewalk were supportive,” Kellogg said. However, the mood flipped from excited to scared and feeling intimidated. “It seems though every office building there was a guy in a blue uniform with binoculars standing in the crowd with troops and police. And if looks could kill me, we could have all been dead.” He says the hatred and intimidation was intense. Kellogg, being white, was an immediate target among many white people. He didn’t realize how dangerous the event in Alabama was until he and the others in the bus heard about the death of Viola Liuzzo. The married mother of five from Detroit was shot and killed by members of the Ku Klux Klan while shuttling activists to the Montgomery airport. “We found out about her death on the ride back,” Kellogg recalled. “Because it was a loss of life, and it shows the violence … we could have been exposed to that danger!” After returning to LU, Kellogg’s outlook on life took a dramatic turn. Kellogg noted King’s belief that a person should be willing to die for important causes. “The idea is that life is about something larger and more important than your own immediate gratification, and career success or personal achievements,” Kellogg said. “The civil rights movement … it made me, it made my life more significant because it was about something important.” The civil rights movement influenced Kellogg to change his career path and to become a black history lecturer. Until this day, he has no regrets and believes that his choices made him as a better individual. The bus ride to Alabama, he says, began with the actions of just one student. Robert Newton Robert Newton was the initiator, recruiter and leader of the Lincoln University movement to join Dr. Martin Luther King’s march in Selma. “In the 60s much of the civil rights activists came out of college,” said Newton during a recent phone interview. Many of the events that involved segregation compelled college students to fight for equality. “We had selected boycotts of merchants, when blacks were not allowed to try on clothes,” Newton said. “You could buy clothes at department stores, but no blacks could work at the department stores as sales people. If you bought clothes there you couldn’t try them on, you had to buy them first and take them home and try them on.” Newton said the students risked their lives to be a part of history and influence change. He not only recognized the historic event of his fellow Lincolnites, but also recognized other college students and historical black colleges and universities who played a vital role in history. “You had the S.N.C.C organization, in terms of voting rights and other things, including a lot of participation and working off the bureau,” Newton said. Other schools and places such as UNT, Greenville and Howard University and other historically black schools had groups that came out as leaders. Newton believes that much has changed from 50 years ago. “I think we’ve certainly come a long way from what I’ve seen from the standpoint of growing up outside of Birmingham, Alabama,” Newton said. He believes that college campuses today are more organized in their approach to social causes. “The campus appears to be some more integrated amongst students in terms of organizations and friendships.” Barbara Flint Dr. Barbara Flint grew up in the southern part of Arkansas and came to Lincoln University in 1961. She describes her experience at Lincoln as “being at Lincoln when the world was changing.“ She was an active member of Lincoln’s History Club, which focused on current events and issues and influenced her decision to join the Selma march. “The first idea was to raise some money and then we started talking about ‘why can’t we go?’ I very much wanted to be a living witness in history.” Reflecting on the march and journey to Montgomery, Flint describes it as being filled with tension. “We were very conscious of the fact that once we got on the road past Tennessee we didn’t know what was going to happen,” said Flint during a February 2015 phone interview. “Many of the students had not been beyond Missouri, so they didn’t have that sense of what happens in the South. Having lived there you knew the balance as well as what is likely to happen and what is not likely to happen. As my father use to say, ‘you have to know how to stay on that line of balance.’” Upon arriving in Alabama she remembers the feeling of excitement and relief from everyone on the bus. “We were tired and very happy to be there and we were trying to figure out where we were going to join and get into the march,” Flint said. “There were so many people coming in and then we were also trying to stay together; that was one of the things that really stuck out for me, not just for us but the people who were coming in. You didn’t want to lose sight of the people you came with.” Flint says she was keenly aware of her surroundings. For her, it was more than just marching forward. “I can still hear those helicopters now,” Flint recalled. “Every time the helicopters would come over the sound would make people jump and look up - I think that demonstrated the extent of the tenseness that was there at the time because the helicopters kept coming over every few minutes.” She said that the marchers sang “we are not afraid,” but that fear remained with every step. “Just having been there and being a witness and marching you realize that I’m one of those drops that’s going to make up this flood and with this flood things will move,” said Flint. As a student at Lincoln in 1965, Flint says the Selma experience undoubtedly changed her life. “You can’t expect to do exactly what you came to Lincoln to do,” Flint says. “That march - along with all the other marchers and the action that was taking place - directly changed the paths that I and many other people at Lincoln would take.” She says current students and new generations need to reflect on their personal role in society. “Decide what needs to be done and ask yourself ‘how can I best contribute to it?’” Flint said. She notes technology and social media can be used to reach audiences in ways unavailable to her generation in 1965. “So you don’t always have to wait for someone else to step out there and say ‘let’s march,’ you can express your vision and your views and you have the means to do so (so) others can follow you. Jaci Newsom Jaci Newsom came to Lincoln in 1965 from Atlanta. She came to Lincoln to major in sociology and being in Jefferson City was largely different from what she had grown up with. “To be able to come into a restaurant, sit down and be served a nice meal was eye-opening to me,” said Newsom during a recent interview. She eventually became accustomed to the relaxed attitude of Missouri and was shocked by the situation she encountered on an out-of-town trip. “I took a bus trip from Atlanta to Pensacola and I encountered the worse racism that I have ever seen. I was at bus stop, I went in to be served and they would not serve me. There was a policeman sitting there at the table and he told me that privately owned places could select not to serve you.” Newsom describes her experience of marching in Montgomery as being one with a purpose. “We felt as though we achieved something - we felt a sense of unity,” Newsom said. “We were very excited (because) we were going to hear from Martin Luther King. To actually be in the presence of him and the other civil rights workers there was just such enthusiasm and excitement yet there was also some apprehension of what we might encounter.” Many of the marchers showed their inspiration and determination while pressing forward towards the grounds of the Alabama Capitol building. Newsom recalled that the marchers were singing the lyrics “ain’t gonna let nobody turn me around” and “we shall overcome.” “ I started seeing people just like me,” Newsom said. “I don’t recall any of the scowling, the hitting, the things I would see on TV later. I just saw a sea of humanity marching towards the Capitol. I don’t remember what Martin Luther King said but it was always the same message: keep the faith; we’re going to get where we’re going and let us remember what our purpose is.” Newsom offers advice on what individuals can do to make their society a more productive and peaceful place. “We have come a long way and we have ways to change things that we did not have before,” Newsom said. “You need to work in positive ways to change.” Referencing the recent unrest in Ferguson, Mo., she believes that people become destructive as a way to show and vent anger. Her generation, she says, was raised to react in lawful ways – and believe in hope. “We have faith to do things in a way that was lawful and it makes me sad what people do when they feel without hope, and there is hope,” Newsom says. “Non-violence does work - we need to include everyone to make this world a better place.” Newsom graduated from Lincoln in 1969 and describes her experience at Lincoln as, “I grew up and did more growing at Lincoln than I think I did for the rest of my life.”
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https://bluetigercommons.lincolnu.edu/lgaines_sec1/1021/thumbnail.jpg
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Esta tese de Doutorado procura estudar os métodos teológicos em diálogo, antropologiatranscendental de Karl Rahner e correlação de Paul Tillich, a partir da sistematização da ontologia existencial elaborada pelo jovem Heidegger em Sein und Zeit. Tanto num, como noutro método, o que se discute é a profundidade do ser, na sua possibilidade de aproximação em superação ao que não pode ser dito. Nesse caso, tanto a metafísica tomista, resgatada por Rahner, quanto a secularização protestante e o abismo do ser, enfatizado por Tillich, assumem a impossibilidade de se dizer o conteúdo do sagrado, exatamente por se situarem ou no inconceito da raiz ontológica (Rahner), ou no excesso de sentido do Ultimate Concern (Tillich). Dessas impossibilades, independente se um antes e depois (Rahner), ou se um depois e um antes em profundidade (Tillich), o que se tem é a pergunta ontológica como possibilidade da abertura do ser, nos dois casos sem conteúdo, para que a resposta , que também não responde, seja dada como (im)possibilidade do deslocamento do ser. No resgate da metafísica tomista, em Rahner, há um deslocamento a partir de um sentido, de certo modo linear , daí antropologia-transcendental. Já na leitura protestante de Tillich, o deslocamento se dá por uma dialética , o ser ameaçado pelo não-ser, como uma unidade rompida, daí correlação. A tese é apresentada em quatro capítulos. No primeiro há uma leitura de Heidegger, pela perspectiva da hermenêutica da compreensão. Já no segundo a reflexão se dá em busca da possibilidade da compreensão pela racionalidade ontológica na correlação, Paul Tillich, pela mediação do simbólico. No terceiro, seguindo as mesmas preocupações, se faz a leitura da epistemologia na racionalidade ontológica na antropologia -transcendental, Karl Rahner, pela mediação da pré-apreensão. O quarto capítulo apresenta temas decorrentes, e tradicionais da teologia, em diálogo a partir dos métodos.(AU)
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Esta tese de Doutorado procura estudar os métodos teológicos em diálogo, antropologiatranscendental de Karl Rahner e correlação de Paul Tillich, a partir da sistematização da ontologia existencial elaborada pelo jovem Heidegger em Sein und Zeit. Tanto num, como noutro método, o que se discute é a profundidade do ser, na sua possibilidade de aproximação em superação ao que não pode ser dito. Nesse caso, tanto a metafísica tomista, resgatada por Rahner, quanto a secularização protestante e o abismo do ser, enfatizado por Tillich, assumem a impossibilidade de se dizer o conteúdo do sagrado, exatamente por se situarem ou no inconceito da raiz ontológica (Rahner), ou no excesso de sentido do Ultimate Concern (Tillich). Dessas impossibilades, independente se um antes e depois (Rahner), ou se um depois e um antes em profundidade (Tillich), o que se tem é a pergunta ontológica como possibilidade da abertura do ser, nos dois casos sem conteúdo, para que a resposta , que também não responde, seja dada como (im)possibilidade do deslocamento do ser. No resgate da metafísica tomista, em Rahner, há um deslocamento a partir de um sentido, de certo modo linear , daí antropologia-transcendental. Já na leitura protestante de Tillich, o deslocamento se dá por uma dialética , o ser ameaçado pelo não-ser, como uma unidade rompida, daí correlação. A tese é apresentada em quatro capítulos. No primeiro há uma leitura de Heidegger, pela perspectiva da hermenêutica da compreensão. Já no segundo a reflexão se dá em busca da possibilidade da compreensão pela racionalidade ontológica na correlação, Paul Tillich, pela mediação do simbólico. No terceiro, seguindo as mesmas preocupações, se faz a leitura da epistemologia na racionalidade ontológica na antropologia -transcendental, Karl Rahner, pela mediação da pré-apreensão. O quarto capítulo apresenta temas decorrentes, e tradicionais da teologia, em diálogo a partir dos métodos.(AU)
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A arte sempre esteve presente entre os humanos como um grande mistério. Sua característica polissêmica nos desafia a pensá-la como algo sempre aberto. Isto é, livre para que os indivíduos a experimentem de formas diversas. Nossa intenção, ao escolher a tela Menino morto do pintor Cândido Portinari, é mostrar que o encontro com uma obra de arte é forçosamente atual, vivo, surpreendente, extraordinário... Não apenas como um mero objeto de prazer, mas, sobretudo, como possibilidades de desvelar experiências originárias, abrindo gamas de sentidos que ajudam os seres humanos a significar a própria existência. Para seguir na investigação, privilegiam-se, nesta dissertação, os estudos sobre as artes do teólogo Paul Tillich e do filósofo Martin Heidegger. Para Tillich, numa obra de arte deve-se buscar o que se esconde no inaparente, pois é aí que reside a sua substância. Assim, na arte, como em qualquer manifestação cultural, por mais secular que aparente ser, se expressa sempre uma preocupação última. Para Heidegger, a arte é fonte de revelação da verdade. Todavia, essa revelação traz em si o ocultamento da mesma verdade, posto que a verdade e a não-verdade acontecem simultaneamente na obra de arte. Portanto, à luz dos estudos feitos por esses dois autores, tentamos captar o desnudar de Menino morto .(AU)
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A arte sempre esteve presente entre os humanos como um grande mistério. Sua característica polissêmica nos desafia a pensá-la como algo sempre aberto. Isto é, livre para que os indivíduos a experimentem de formas diversas. Nossa intenção, ao escolher a tela Menino morto do pintor Cândido Portinari, é mostrar que o encontro com uma obra de arte é forçosamente atual, vivo, surpreendente, extraordinário... Não apenas como um mero objeto de prazer, mas, sobretudo, como possibilidades de desvelar experiências originárias, abrindo gamas de sentidos que ajudam os seres humanos a significar a própria existência. Para seguir na investigação, privilegiam-se, nesta dissertação, os estudos sobre as artes do teólogo Paul Tillich e do filósofo Martin Heidegger. Para Tillich, numa obra de arte deve-se buscar o que se esconde no inaparente, pois é aí que reside a sua substância. Assim, na arte, como em qualquer manifestação cultural, por mais secular que aparente ser, se expressa sempre uma preocupação última. Para Heidegger, a arte é fonte de revelação da verdade. Todavia, essa revelação traz em si o ocultamento da mesma verdade, posto que a verdade e a não-verdade acontecem simultaneamente na obra de arte. Portanto, à luz dos estudos feitos por esses dois autores, tentamos captar o desnudar de Menino morto .(AU)
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Esta pesquisa tem por objetivo analisar sob quais aspectos se dá a interação entre mídia e religião, bem como as tensões ou continuidades que a aproximação do ‘sagrado’ com o ‘profano’ na sociedade midiatizada evoca. Para tal, elegemos como objeto de estudo a participação dos artistas evangélicos no Programa Esquenta!, exibido nas tardes de domingo, pela Rede Globo. Tomamos como referencial teórico os conceitos de cultura gospel, de midiatização, especialmente o conceito de bios midiático, e a discussão sobre secularização proposta por Habermas. A metodologia empregada prevê duas etapas. A primeira consiste numa uma análise de conteúdo de cinco edições do programa que contaram com a participação de artistas evangélicos, exibidas nos anos de 2013 e 2014. Nesse momento, o objetivo foi perceber o lugar que a música gospel ocupa dentro da proposta do programa. A segunda etapa consiste na realização de dois grupos de discussão, um formado por evangélicos e o outro por não-evangélicos, para compreender como os conteúdos religiosos deslocados de seu contexto original são ressignificados pela audiência. Resulta desta pesquisa a observação de que a participação dos artistas gospel no Esquenta! oferece novos modos de olhar que ampliam o conceito de cultura gospel, bem como legitima a mídia como lugar de experiência religiosa. Além disso, ilustra a perspectiva habermasiana ao refletir a dupla afetação entre universo religioso e vida secular, que emerge do entrecruzamento entre mídia e religião.
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A pesquisa tem por objetivo trabalhar o evento da Revolta de Jeú, em conjunto com a Estela de Dã, tendo como ponto de partida para tal, a exegese da perícope de 2 Reis 10-28,36. A história Deuteronomista apresenta o ato da Revolta de Jeú como sendo um feito demasiadamente importante, na restauração do culto a Javé em Israel, a partir de um contexto onde o culto a outras divindades, em Israel Norte, estava em pleno curso. No entanto, a partir da análise conjunta da Estela de Dã, que tem como provável autor o rei Hazael de Damasco, somos desafiados a ler esta história pelas entrelinhas não contempladas pelo texto, que apontam para uma participação ativa de Hazael, nos desfechos referentes a Revolta de Jeú, como sendo o responsável direto que proporcionou a subida de Jeú ao trono em Israel, clarificando desta forma este importante período na história Bíblica. Para tal análise, observar-se-á três distintos tópicos, ligados diretamente ao tema proposto: (1) A Revolta de Jeú e a Redação Deuteronomista, a partir do estudo exegético da perícope de 2 Reis 10,28-36, onde estão descritas informações pontuais sobre período em que Jeú reinou em Israel; (2) Jeú e a Estela de Dã, a partir da apresentação e análise do conteúdo da Estela de Dã, tratando diretamente dos desdobramentos da guerra em Ramote de Gileade, de onde se dá o ponto de partida à Revolta de Jeú; e por fim (3) O Império da Síria, onde a partir da continuidade da análise do conteúdo da Estela de Dã, demonstraremos a significância deste reino, além de apontamentos diretamente ligados ao reinado de Hazael, personagem mui relevante no evento da Revolta de Jeú.
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Both reversible and irreversible inhibition of mitochondrial respiration have been reported following the generation of nitric oxide (NO) by cells. Using J774 cells, we have studied the effect of long-term exposure to NO on different enzymes of the respiratory chain. Our results show that, although NO inhibits complex IV in a way that is always reversible, prolonged exposure to NO results in a gradual and persistent inhibition of complex I that is concomitant with a reduction in the intracellular concentration of reduced glutathione. This inhibition appears to result from S-nitrosylation of critical thiols in the enzyme complex because it can be immediately reversed by exposing the cells to high intensity light or by replenishment of intracellular reduced glutathione. Furthermore, decreasing the concentration of reduced glutathione accelerates the process of persistent inhibition. Our results suggest that, although NO may regulate cell respiration physiologically by its action on complex IV, long-term exposure to NO leads to persistent inhibition of complex I and potentially to cell pathology.
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Acknowledgements We would like to thank Charles and Helen Gray for permitting access to the land and for support in the excavation of the hoard. Thanks also to Bruce Mann and the Aberdeenshire Council Archaeology Service for advice and supporting the radiocarbon dating. Fraser Hunter and Tanja Romankiewicz assisted during a very cold excavation. Fraser and Alice Blackwell kindly read and commented on drafts of this paper. The fieldwork was funded through a donation to the University of Aberdeen’s Development Trust and undertaken as part of the Northern Picts project, in association with the Tarbat Discovery Centre.
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Peer reviewed
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Bibliografia.
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Inclui bibliografia.
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Acute stress increases the risk for neurodegeneration, but the molecular signals regulating the shift from transient stress responses to progressive disease are not yet known. The “read-through” variant of acetylcholinesterase (AChE-R) accumulates in the mammalian brain under acute stress. Therefore, markers of neurodeterioration were examined in transgenic mice overexpressing either AChE-R or the “synaptic” AChE variant, AChE-S. Several observations demonstrate that excess AChE-R attenuates, whereas AChE-S intensifies, neurodeterioration. In the somatosensory cortex, AChE-S transgenics, but not AChE-R or control FVB/N mice, displayed a high density of curled neuronal processes indicative of hyperexcitation. In the hippocampus, AChE-S and control mice, but not AChE-R transgenics, presented progressive accumulation of clustered, heat shock protein 70–immunopositive neuronal fragments and displayed a high incidence of reactive astrocytes. Our findings suggest that AChE-R serves as a modulator that may play a role in preventing the shift from transient, acute stress to progressive neurological disease.
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The telomerase enzyme is a potential therapeutic target in many human cancers. A series of potent inhibitors has been designed by computer modeling, which exploit the unique structural features of quadruplex DNA. These 3,6,9-trisubstituted acridine inhibitors are predicted to interact selectively with the human DNA quadruplex structure, as a means of specifically inhibiting the action of human telomerase in extending the length of single-stranded telomeric DNA. The anilino substituent at the 9-position of the acridine chromophore is predicted to lie in a third groove of the quadruplex. Calculated relative binding energies predict enhanced selectivity compared with earlier 3,6-disubstituted compounds, as a result of this substituent. The ranking order of energies is in accord with equilibrium binding constants for quadruplex measured by surface plasmon resonance techniques, which also show reduced duplex binding compared with the disubstituted compounds. The 3,6,9-trisubstututed acridines have potent in vitro inhibitory activity against human telomerase, with EC50 values of up to 60 nM.