Produtividade da cana-de-açúcar fertirrigada com N e K via gotejamento subsuperficial

O objetivo deste trabalho consistiu no estudo da fertirrigação por gotejamento subsuperficial na produtividade da cana-de-açúcar, no segundo e terceiro ciclos de cultivo, e os efeitos nos índices tecnológicos na cultura. O experimento foi desenvolvido na área experimental da Faculdade de Ciências Agronômicas, FCA/UNESP - Botucatu. O tubo gotejador foi instalado a 30 cm de profundidade e sob a fileira de plantio da cana-de-açúcar. A variedade cultivada foi a RB 72454. O tratamento com a aplicação da maior dose de NK via fertirrigação foi o que respondeu melhor, apresentando produtividade de colmos de 190,01 t ha-1 e 168,80 t ha-1 para o segundo e terceiro ciclos, respectivamente. A fertirrigação não alterou a qualidade tecnológica da cana-de-açúcar nos dois ciclos estudados e proporcionou incrementos na produção de colmos em relação à testemunha, de 43,5% e 67,2%, para o segundo e terceiro cortes, respectivamente.

Padrão de distribuição de K+, Ca++, Mg++ e P no solo de um pomar de citros em função da fertirrigação

Em solos tropicais, a distribuição dos nutrientes no solo em função da fertirrigação realizada por meio de irrigação localizada (gotejamento e/ou microaspersão), na cultura de citros, é pouco conhecida. Este trabalho teve por objetivo avaliar os padrões de distribuição de potássio, cálcio, magnésio e fósforo em solo tropical, em função da fertirrigação, aplicada por dois sistemas de irrigação localizada (microaspersão e gotejamento), sendo que o sistema por gotejamento era composto por uma e duas linhas laterais por linha de plantas, e o de microaspersão por apenas uma linha, e com três dotações hídricas (100%, 75% e 50%) da evapotranspiração da cultura (ETc), em um pomar de laranjeira. As fontes de fertilizantes utilizadas na fertirrigação foram o nitrato de amônio (fonte de N), o cloreto de potássio (fonte de K+) e o ácido fosfórico (fonte de P). Observouse que, sob o emissor, nos tratamentos com gotejamento, houve depleção nos teores de Ca++ e Mg++ desde a superfície do solo até 60 cm de profundidade em relação aos teores anteriores às fertirrigações, enquanto os teores de P aumentaram, principalmente na camada de 0 cm a 20 cm. Na microaspersão, esses efeitos não foram observados, ocorrendo distribuição mais homogênea desses nutrientes tanto na direção transversal à linha de plantas quanto em profundidade. As lâminas de irrigação aplicadas por irrigação localizada não interferem na distribuição de K+ aplicado por fertirrigação e do Ca++ e Mg++ no solo em profundidade, porém menores lâminas de irrigação promovem maior concentração de P na camada mais superficial do solo, e lâminas maiores carregam o P para camadas mais profundas.

A biologia molecular no prognóstico do carcinoma da tireóide

This overview examines some selected genetic mechanisms of cancer development. Strong evidence has been accumulated suggesting that alteration in either the struture or activity of proto-oncogene contributes to the development and for the maintenance of the malignant phenotype. Many factors are known to interfere with both normal and pathological controls of growth and differentiation of thyroid cells. Among them, some are oncogenes, like those encoding g-proteins (ras, gsp, TSH-R), encoding thyrosino kinases receptors (RET, trk, c-met, c-erb, BRAF) and encoding nuclear proteins (c-myc, e-fós). Others are anti-oncogenes (p53, p15, RB), by loss of the growth suppression ativity of the suppressive gene. Cancer cell invasion and metastasis are the major causes of morbidity and mortality in cancer patients. Many genes are involved in the mechanism of invasion and metastasis of thyroid tumors, like Nis, b-catenina, E-caderina, galectina-3, GLUT, telomerase, VEGT, nm-23. All these oncogenes, antioncogenes and tumor invasion and metastasis-related genes are analysed. Several clinical and prognostic factors have been proposed to identify patients at risk for the development of metastasis and death. The role of molecular genetics in this issue is discussed. However, other studies are needed to validate molecular alterations as an independent prognostic factor in thyroid cancer.

The Roots of Neurofibromas in Neurofibromatosis 1 — A Question of Multipotency, Differentiation and Hiding

Neurofibromatosis type 1 (NF1) is an autosomal dominant cancer predisposition syndrome that affects about 1 in 3500 individuals worldwide. NF1 is caused by mutations in the NF1 gene that encodes the tumor suppressor protein neurofibromin, an inactivator of the Ras oncogene. The hallmarks of NF1 include pigmentary lesions of the skin, Lisch nodules of the iris and cutaneous neurofibromas. Cutaneous neurofibromas are benign tumors composed of all the cell types of normal peripheral nerve. The traditional view of neurofibroma development has been that cutaneous neurofibromas arise from the disruption of the small nerve tributaries of the skin and subsequent proliferation of the resident cells. The second hit mutation in the NF1 gene has been considered as a prerequisite for neurofibroma development. The second hit is detectable in a subpopulation of primary Schwann cells cultured from neurofibromas. This thesis challenges the traditional concept of neurofibroma development. The results show that cutaneous neurofibromas are intimately associated with hair follicular structures and contain multipotent precursor cells (NFPs), suggesting that neurofibromas may arise from the multipotent cells which reside in hair follicles. Furthermore, this study presents that neurofibroma-derived Schwann cells that harbor bi-allelic inactivation in the NF1 gene express HLA class II genes and may act as nonprofessional antigen presenting cells. The CD4- and FoxP3-positive cells detected in cutaneous neurofibromas suggest that these cells may represent regulatory T cells (Tregs) which interact with HLA II –positive cells and aid the tumor cells in hiding from the immune system and are thus mediators of immune tolerance. This thesis also investigated neurofibroma development in the oral cavity and the use of different biomarkers to characterize cellular differentiation in neurofibromas. The results revealed that oral neurofibromas are not rare, but they usually appear as solitary lesions contrary to multiple cutaneous neurofibromas and present high heterogeneity within and between tumors. The use of class III beta-tubulin as a marker for neuronal differentiation led to an unexpected finding showing that multiple cell types express class III beta-tubulin during mitosis. The increased understanding of the multipotency of tumor cells, cellular differentiation and ability to hide from immune system will aid in the development of future treatments. Specifically, targeting Tregs in NF1 patients could provide a novel therapeutic approach to interfere with the development of neurofibromas.

Pk-yritysten ja korkeakoulujen (teknologia) T&K&I yhteistyön kehittäminen teollisuuden toimialoilla

The aim of this work is to develop entrepreneurship in university technology side. The means of SMEs is made in collaboration with the research development and innovation projects. At the same time supporting and enabling the growth of SMEs, the internationalization of higher education and increase student’s employability in SMEs. The aim is to create new startup companies with the help of co-operation both SMEs and universities, especially assist companies find the successor generation of change by improving interaction between the parties. The new growth oriented entrepreneurial business creation with help of SMEs will be seen more business supporting and opening more opportunities. Portfolio Entrepreneurship is a form of the company’s growth, even the size of company does not change so much. Portfolio Entrepreneurship is an alternative for entrepreneurs which do have possibilities to expand, but they do like keep it as family business. Variety can be seen in expansion if the SMEs have common interest to do so. Co-made projects, between SMEs and universities, are seen to be significantly affecting the wellbeing of society as a whole, and eve international level. Co-operation is considered to be also affected the quality of learning and teachers’ professional development. higher education supports the change of the supports to innovation when it is done with SMEs. Research material has been collected by interviewing the experts, who have already distinguished themselves in their field. Problem focused interviews as method gave the ways how the university students and SMEs can proceed and promote on industrial sector.

I Brunnshuset. Fredagen den 1 (13) Juli 1855, H. K. M:t Enke-Keijsarinnan Alexandra Fedorownas höga födelsedag

Ilmoitus. Ruotsin- ja venäjänkielinen

Suomen Ratsastusliiton ratsastuskilpailut Pohjois-sataman raviradalla sunnuntaina helmikuun 24 päivänä k:o 1 i.p

14 x 22 cm

Suomen kanoottimestaruuskilpailut ja H.K.K:n 10-vuotisjuhlakilpailut 10-12. VIII. 1935

12 x 23 cm

K.-h.-piiri

21 x 15 cm

K.-h.-piiri

21 x 15 cm

Suomen mestaruus- ja H.K.K:n 15-vuotiskilpailut kanoottiurheilussa 3—4 p:nä elokuuta 1940 Soutu- ja Melontastadionilla

15 x 22 cm

Suomen Rauhanliiton (K.Y.) Turun osaston 10:n vuotisjuhla

8 x 19 cm