Illuminating the detection chain of bacterial bioreporters.

Engineering bacteria for measuring chemicals of environmental or toxicological concern (bioreporter bacteria) has grown slowly into a mature research area. Despite many potential advantages, current bioreporters do not perform well enough to comply with environmental detection standards. Basically, the reasons for this are the lack of engineering principles in the detection chain in the bioreporters. Here, we dissect critical steps in the detection chain and illustrate how bioreporter design could be improved by mutagenizing specificity and selectivity of the sensing and regulatory proteins, by newer expression strategies and application of different signalling networks. Furthermore, we describe how redesigning bioreporter assays with respect to pollutant transport into the cells and application of other detection devices can decrease detection limits and increase the speed of detection.

IDED Quick News, October 31, 2003,

Newsletter for Iowa Department of Economic Development.

IDED Quick News, September 30, 2003

Newletter for the Department of Economic Development.

IDED Quick News, September 2, 2003

Newsletter for Economic Devleopment

IDED Quick News July 25, 2003

Newsletter for Economic Development

IDED Quick News, July 1, 2003

Newsletter for Economic Devlopment

IDED Quick News, May 29, 2003

Newsletter for Economic Development

IDED Quick News, May 2, 2003

Newsletter for Economic Development

IDED Quick News, March 27, 2003

Newsletter for Economic Development

IDED Quick News, February 28, 2003

Newsletter for Economic Development

IDED Quick News, January 23, 2003

Newsletter for Economic Development

IDED Quick News, May 23, 2002

Newsletter for Economic Development

IDED Quick News, July 5, 2002

Annual Report

IDED Quick News, July 29, 2002

Newsletter for Economic Development

IDED Quick News, July 29, 2002

Newsletter for Economic Development