Polycaprolactone fibres as a potential delivery system for collagen to support bone regeneration

Poly(e-caprolactone) (PCL) is biocompatible, non-immunogenic and non-toxic, and slowly degrades, allowing sufficient time for tissue regeneration. PCL has the potential for application in bone and cartilage repair as it may provide the essential structure required for bone regeneration, however, an ideal scaffold system is still undeveloped. PCL fibres were prepared using the gravity spinning technique, in which collagen was either incorporated into or coated onto the 'as-spun' fibres, in order to develop novel biodegradable polymer fibres which will effectively deliver collagen and support the attachment and proliferation of human osteoblast (HOB) cells for bone regeneration. The physical and mechanical characteristics and cell fibre interactions were analysed. The PCL fibres were found to be highly flexible and inclusion of collagen did not alter the mechanical properties of PCL fibres. Overall, HOB cells were shown to effectively adhere and proliferate on all fibre platforms tested, although proliferation rates were enhanced by surface coating PCL fibres with collagen compared to PCL fibres incorporating collagen and PCL-only fibres. These findings highlight the potential of using gravity spun PCL fibres as a delivery platform for extracellular matrix proteins, such as collagen, in order to enhance cell adherence and proliferation for tissue repair.

Progress in multichannel all-optical regeneration based on fiber technology

Multiwavelength all-optical regeneration has the potential to substantially increase both the capacity and scalability of future optical networks. In this paper, we review recent promising developments in this area. First, we recall the basic principles of multichannel regeneration of high bit rate signals in optical communication systems before discussing the current technological approaches. We then describe in detail two fiber-based multichannel 2R regeneration techniques for return-to-zero-on-off keying based on 1) dispersion managed systems and 2) direction and polarization multiplexing. We present results illustrating the levels of performance so far achieved and discuss various practical issues and prospects for further performance enhancement.

'Worlds of justification’ in the politics and practices of urban regeneration

A considerable body of research has developed on processes of neoliberal urban regeneration and gentrifi cation. On the one hand, there are many political economy accounts emphasising the role of economic capital in processes of urban change and gentrifi cation. On the other hand, there is a wealth of governmentality studies on the art of government that fail to explain how ungovernable subjects develop. Similarly, within gentrifi cation studies there are many accounts on the role of changing consumer lifestyles and defi ning gentrifi cation, but less concern with the governance processes between actors in urban regeneration and gentrifi cation. Yet such issues are of considerable importance given the role of the state in urban regeneration and dependence on private capital. This paper utilises the French Pragmatist approach of Boltanski and Thévenot to examine a case study state-led gentrifi cation project. Boltanski and Thévenot argue that social coordination occurs by way of actors working through broader value-laden ‘worlds of justifi cation’ that underpin processes of argumentation and coordination. The examined case study is a deprived area within an English city where a major state-led gentrification programme has been introduced. The rationale for the programme is based on the assumption that reducing deprivation relies upon substantially increasing the number of higher income earners. The paper concludes that market values have overridden broader civic values in the negotiation process, with this intensifying as the state internalised market crisis tendencies within the project. More broadly, there is a need for French Pragmatism to be more sensitive to the spatial processes of social coordination, which can be achieved through critical engagement with recent concepts of ‘assemblages’.

A practical phase sensitive amplification scheme for two channel phase regeneration

A "black-box" phase sensitive amplifier is presented achieving simultaneous suppression of deterministic phase distortion on two independent 42.66 Gbit/s DPSK modulated signal wavelengths.

DPSK signal regeneration with a dual-pump nondegenerate phase-sensitive amplifier

We demonstrate, for the first time to our knowledge, regeneration of a 42.66-Gb/s differential phase-shift keyed signal using a dual-pump nondegenerate four-wave-mixing-based fiber-optic parametric amplifier. The regenerative performance of the subsystem is characterized in terms of bit-error rate against narrowband and wideband introduced noise. While a strong receiver sensitivity improvement, up to 20 dB, is noticed against narrowband noise, against quasi-random (wideband) noise we observe a regeneration of 2.7 dB.

Simultaneous dual channel phase regeneration in SOAs

For the first time we demonstrate simultaneous suppression of phase distortion on two independent 10.7 Gbit/s DPSK modulated signal wavelengths using semiconductor optical amplifiers, realizing a compact phase sensitive amplifier with low power consumption.

Multi-wavelength regeneration of phase encoded signals based on phase sensitive amplifiers

Future high capacity optical links will have to make use of frequent signal regeneration to enable long distance transmission. In this respect, the role of all-optical signal processing becomes increasingly important because of its potential to mitigate signal impairments at low cost and power consumption. More substantial benefits are expected if regeneration is achieved simultaneously on a multiple signal band. Until recently, this had been achieved only for on-off keying modulation formats. However, as in future transmission links the information will be encoded also in the phase for enhancing the spectral efficiency, novel subsystem concepts will be needed for multichannel processing of such advanced signal formats. In this paper we show that phase sensitive amplifiers can be an ideal technology platform for developing such regenerators and we discuss our recent demonstration of the first multi-channel regenerator for phase encoded signals.

Design of Raman-based NOLM for optical 2R regeneration of RZ-DPSK transmission

We present a concept for all-optical differential phase-shift keying (DPSK) signal regeneration, based on a new design of Raman amplified nonlinear loop mirror (RA-NOLM). We demonstrate simultaneous amplitude-shape regeneration and phase noise reduction in high-speed DPSK systems by use of the RA-NOLM combined with spectral filtering.

All-optical passive 2R regeneration of dispersion-managed RZ data at 40 and 80 Gbit/s using in-line NOLMs

We demonstrate that the use of in-line nonlinear optical loop mirrors (NOLMs) in dispersion-managed (DM) transmission systems dominated by amplitude noise can achieve passive 2R regeneration of a 40 and 80 Gbit/s RZ data stream. This is an indication that the use of this approach could obviate the need for full-regeneration in high data rate, strong DM systems, when intra-channel four-wave mixing poses serious problems.

Design of Raman-based nonlinear loop mirror for all-optical 2R regeneration of differential phase-shift-keying transmission

We present a concept for all-optical regeneration of signals modulated in phase-sensitive modulation formats, which is based on a new design of Raman amplified nonlinear optical loop mirror (RA-NOLM). We demonstrate simultaneous amplitude-shape regeneration and phase-noise reduction in high-speed differential phase-shift-keying transmission systems by use of the RA-NOLM combined with spectral filtering.

All-optical signal regeneration by temporal slicing of nonlinearly flattened optical waveform

A novel all-optical time domain regeneration technique using nonlinear pulse broadening and flattening in normal dispersion fiber and subsequent temporal slicing by an amplitude modulator (or a device performing a similar function) is proposed. Substantial suppression of the timing jitter of jitter-degraded optical signals is demonstrated using the proposed approach.