Motor Vehicle Crash Fatalities for Week Ending, October 24, 2010,

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities for Week Ending, September 24, 2010, revised

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities for Week Ending, November 5, 2010,

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities for Week Ending, November 12, 2010,

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities for Week Ending, November 19, 2010,

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities for Week Ending, November 24, 2010,

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities for Week Ending, December 3, 2010,

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities for Week Ending, December 10, 2010,

Motor Vehicle Crash Fatalities

A cnidarian homologue of an insect gustatory receptor functions in developmental body patterning.

Insect gustatory and odorant receptors (GRs and ORs) form a superfamily of novel transmembrane proteins, which are expressed in chemosensory neurons that detect environmental stimuli. Here we identify homologues of GRs (Gustatory receptor-like (Grl) genes) in genomes across Protostomia, Deuterostomia and non-Bilateria. Surprisingly, two Grls in the cnidarian Nematostella vectensis, NvecGrl1 and NvecGrl2, are expressed early in development, in the blastula and gastrula, but not at later stages when a putative chemosensory organ forms. NvecGrl1 transcripts are detected around the aboral pole, considered the equivalent to the head-forming region of Bilateria. Morpholino-mediated knockdown of NvecGrl1 causes developmental patterning defects of this region, leading to animals lacking the apical sensory organ. A deuterostome Grl from the sea urchin Strongylocentrotus purpuratus displays similar patterns of developmental expression. These results reveal an early evolutionary origin of the insect chemosensory receptor family and raise the possibility that their ancestral role was in embryonic development.

Motor Vehicle Crash Fatalities for Week Ending, December 24, 2010,

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities for Week Ending, December 30, 2010,

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities Year End Report, January 7, 2011

Motor Vehicle Crash Fatalities

Focal dystonia and the Sensory-Motor Integrative Loop for Enacting (SMILE).

Performing accurate movements requires preparation, execution, and monitoring mechanisms. The first two are coded by the motor system, the latter by the sensory system. To provide an adaptive neural basis to overt behaviors, motor and sensory information has to be properly integrated in a reciprocal feedback loop. Abnormalities in this sensory-motor loop are involved in movement disorders such as focal dystonia, a hyperkinetic alteration affecting only a specific body part and characterized by sensory and motor deficits in the absence of basic motor impairments. Despite the fundamental impact of sensory-motor integration mechanisms on daily life, the general principles of healthy and pathological anatomic-functional organization of sensory-motor integration remain to be clarified. Based on the available data from experimental psychology, neurophysiology, and neuroimaging, we propose a bio-computational model of sensory-motor integration: the Sensory-Motor Integrative Loop for Enacting (SMILE). Aiming at direct therapeutic implementations and with the final target of implementing novel intervention protocols for motor rehabilitation, our main goal is to provide the information necessary for further validating the SMILE model. By translating neuroscientific hypotheses into empirical investigations and clinically relevant questions, the prediction based on the SMILE model can be further extended to other pathological conditions characterized by impaired sensory-motor integration.

Motor Vehicle Crash Fatalities, January 21, 2011

Motor Vehicle Crash Fatalities

Motor Vehicle Crash Fatalities, January 21, 2011, Part II

Motor Vehicle Crash Fatalities