971 resultados para Manchester By The Sea


Relevância:

100.00% 100.00%

Publicador:

Resumo:

http://www.archive.org/details/portraitsofameri00hawarich

Relevância:

100.00% 100.00%

Publicador:

Resumo:

http://www.archive.org/details/rethinkingmissio011901mbp

Relevância:

100.00% 100.00%

Publicador:

Resumo:

http://www.archive.org/details/coloradomission02spalrich

Relevância:

100.00% 100.00%

Publicador:

Resumo:

http://www.archive.org/details/oldspaininnewame00mcleiala

Relevância:

100.00% 100.00%

Publicador:

Resumo:

http://digilib.bu.edu/archive/strangerthanfict00halcrich/strangerthanfict00halcrich.djvu

Relevância:

100.00% 100.00%

Publicador:

Resumo:

Similarly to protein folding, the association of two proteins is driven by a free energy funnel, determined by favorable interactions in some neighborhood of the native state. We describe a docking method based on stochastic global minimization of funnel-shaped energy functions in the space of rigid body motions (SE(3)) while accounting for flexibility of the interface side chains. The method, called semi-definite programming-based underestimation (SDU), employs a general quadratic function to underestimate a set of local energy minima and uses the resulting underestimator to bias further sampling. While SDU effectively minimizes functions with funnel-shaped basins, its application to docking in the rotational and translational space SE(3) is not straightforward due to the geometry of that space. We introduce a strategy that uses separate independent variables for side-chain optimization, center-to-center distance of the two proteins, and five angular descriptors of the relative orientations of the molecules. The removal of the center-to-center distance turns out to vastly improve the efficiency of the search, because the five-dimensional space now exhibits a well-behaved energy surface suitable for underestimation. This algorithm explores the free energy surface spanned by encounter complexes that correspond to local free energy minima and shows similarity to the model of macromolecular association that proceeds through a series of collisions. Results for standard protein docking benchmarks establish that in this space the free energy landscape is a funnel in a reasonably broad neighborhood of the native state and that the SDU strategy can generate docking predictions with less than 5 � ligand interface Ca root-mean-square deviation while achieving an approximately 20-fold efficiency gain compared to Monte Carlo methods.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

ART-EMAP synthesizes adaptive resonance theory (AHT) and spatial and temporal evidence integration for dynamic predictive mapping (EMAP). The network extends the capabilities of fuzzy ARTMAP in four incremental stages. Stage I introduces distributed pattern representation at a view category field. Stage 2 adds a decision criterion to the mapping between view and object categories, delaying identification of ambiguous objects when faced with a low confidence prediction. Stage 3 augments the system with a field where evidence accumulates in medium-term memory (MTM). Stage 4 adds an unsupervised learning process to fine-tune performance after the limited initial period of supervised network training. Simulations of the four ART-EMAP stages demonstrate performance on a difficult 3-D object recognition problem.

Relevância:

100.00% 100.00%

Publicador:

Resumo:

An improved Boundary Contour System (BCS) neural network model of preattentive vision is applied to two images that produce strong "pop-out" of emergent groupings in humans. In humans these images generate groupings collinear with or perpendicular to image contrasts. Analogous groupings occur in computer simulations of the model. Long-range cooperative and short-range competitive processes of the BCS dynamically form the stable groupings of texture regions in response to the images.