Hki 5/8 1943

Kirje 5.8.1943

Iowa's 5 Percent Safety Report, 2006

A report of Iowa's top 5 percent of locations with the most severe safety needs, as required by the most recent federal highway reauthorization bill.

IoWoman September/October 2006, Vol.36, no.5

Newsletter for the Iowa Commission on the Status of Women

Puhemies Rafael Paasio 19/5 1966

Kirje

Kirjailija Ilmari Kianto 28/5 1966

Kirje 28.5.1966

Till Herr Chefredaktören 13.5.1973

Kirje

Förlagsdirektör Erik Westerberg 2/5 1967

Kirje 2.5.1967

Secreted proteases from dermatophytes

Dermatophytes are highly specialized pathogenic fungi that exclusively infect the stratum corneum, nails or hair, and it is evident that secreted proteolytic activity is important for their virulence. Endo- and exoproteases-secreted by dermatophytes are similar to those of species of the genus Aspergillus. However, in contrast to Aspergillus spp., dermatophyte-secreted endoproteases are multiple and are members of two large protein families, the subtilisins (serine proteases) and the fungalysins (metalloproteases). In addition, dermatophytes excrete sulphite as a reducing agent. In the presence of sulphite, disulphide bounds of the keratin substrate are directly cleaved to cysteine and S-sulphocysteine, and reduced proteins become accessible for further digestion by various endo- and exoproteases secreted by the fungi. Sulphitolysis is likely to be an essential step in the digestion of compact keratinized tissues which precedes the action of all proteases.

Ellen Niemelä-Pylkkänen 5/4 1975

Kirje 5.4.1975