40 years of the regional gender agenda

The first Regional Conference on the Integration of Women into the Economic and Social Development of Latin America and the Caribbean was held almost 40 years ago (Havana, 1977). It provided a regional forum for exchange after the World Conference of the International Women’s Year in Mexico City in 1975, where participants supported the idea of social demands for women’s rights and gender equality (which were starting to spread from country to country) being converted into government commitments. On that occasion they adopted the Regional Plan of Action for the Integration of Women into Latin American Economic and Social Development, the region’s first road map for progress towards the recognition of women’s contribution to society and the obstacles that they face in improving their situation. At that same conference, the Governments gave the Economic Commission for Latin America and the Caribbean (ECLAC) a mandate to convene periodically, at intervals of no more than three years, a Regional Conference on Women. In fulfilment of this mandate, over the next four decades ECLAC organized 12 Regional Conferences on Women, first through its Women and Development Unit, then its Division for Gender Affairs. This interaction between governments, with the active participation of the women’s and feminist movement and the support of the entire United Nations system, has become the main forum for the negotiation of a broad, profound and comprehensive regional agenda on gender equality, in which women’s autonomy and rights are front and centre. Policies for development and overcoming poverty have always been a key focus at these meetings. This publication is a compilation of all the agreements adopted by the Governments at the regional conferences and will serve not only as a tool for reference, but above all as a tool for action and for building a future based on the collective memory of the women of Latin America and the Caribbean.

Fat as an endocrine organ: Relationship to the metabolic syndrome

Obesity and the metabolic syndrome have both reached pandemic proportions. Together they have the potential to impact on the incidence and severity of cardiovascular pathologies, with grave implications for worldwide health care systems. The metabolic syndrome is characterized by visceral obesity, insulin resistance, hypertension, chronic inflammation, and thrombotic disorders contributing to endothelial dysfunction and, subsequently, to accelerated atherosclerosis. Obesity is a key component in development of the metabolic syndrome and it is becoming increasingly clear that a central factor in this is the production by adipose cells of bioactive substances that directly influence insulin sensitivity and vascular injury. In this paper, we review advances in the understanding of biologically active molecules collectively referred to as adipokines and how dysregulated production of these factors in obese states mediates the pathogenesis of obesity associated metabolic syndrome.

Brain maps, great and small: lessons from comparative studies of primate visual cortical organization

In this paper, we review evidence from comparative studies of primate cortical organization, highlighting recent findings and hypotheses that may help us to understand the rules governing evolutionary changes of the cortical map and the process of formation of areas during development. We argue that clear unequivocal views of cortical areas and their homologies are more likely to emerge for 'core' fields, including the primary sensory areas, which are specified early in development by precise molecular identification steps. In primates, the middle temporal area is probably one of these primordial cortical fields. Areas that form at progressively later stages of development correspond to progressively more recent evolutionary events, their development being less firmly anchored in molecular specification. The certainty with which areal boundaries can be delimited, and likely homologies can be assigned, becomes increasingly blurred in parallel with this evolutionary/developmental sequence. For example, while current concepts for the definition of cortical areas have been vindicated in allowing a clarification of the organization of the New World monkey 'third tier' visual cortex (the third and dorsomedial areas, V3 and DM), our analyses suggest that more flexible mapping criteria may be needed to unravel the organization of higher-order visual association and polysensory areas.