George 2nd Earl of Warwick [Material gráfico] : From the original picture in the possession of the Earl Warwick

Resumen: Descripción: retrato de niño de tres cuartos de figura mirando de frente

Urban voids, spaces of great expectations

Study and progress of urban voids. opportunities for new urban design.

Little journeys to homes of great scientists ... written by Elbert Hubbard ...

bk. 2

Little journeys to homes of great scientists ... written by Elbert Hubbard ...

bk. 1

Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans

Keratinocyte growth factor (KGF) is a member of the fibroblast growth factor family. Portions of the gene encoding KGF were amplified during primate evolution and are present in multiple nonprocessed copies in the human genome. Nucleotide analysis of a representative sampling of these KGF-like sequences indicated that they were at least 95% identical to corresponding regions of the KGF gene. To localize these sequences to specific chromosomal sites in human and higher primates, we used fluorescence in situ hybridization. In human, using a cosmid probe encoding KGF exon 1, we assigned the location of the KGF gene to chromosome 15q15–21.1. In addition, copies of KGF-like sequences hybridizing only with a cosmid probe encoding exons 2 and 3 were localized to dispersed sites on chromosome 2q21, 9p11, 9q12–13, 18p11, 18q11, 21q11, and 21q21.1. The distribution of KGF-like sequences suggests a role for alphoid DNA in their amplification and dispersion. In chimpanzee, KGF-like sequences were observed at five chromosomal sites, which were each homologous to sites in human, while in gorilla, a subset of four of these homologous sites was identified; in orangutan two sites were identified, while gibbon exhibited only a single site. The chromosomal localization of KGF sequences in human and great ape genomes indicates that amplification and dispersion occurred in multiple discrete steps, with initial KGF gene duplication and dispersion taking place in gibbon and involving loci corresponding to human chromosomes 15 and 21. These findings support the concept of a closer evolutionary relationship of human and chimpanzee and a possible selective pressure for such dispersion during the evolution of higher primates.

Quarterly Journal of Science, Literature and the Arts.

1829 (July - Dec.)

IV. Reminiscences of life as an undergraduate at Harvard College from 1793 to 1797, 1837

This memoir, written by White in 1837, describes his undergraduate years at Harvard from 1793 to 1797. It contains lengthy passages about a wide variety of experiences White had as a student. He wrote about his classes and professors, student life, American politics, politics in the world at large, food, his classmates, and many other topics. The memoir includes passages from a diary that White seems to have kept as a student, as well as reflections clearly written later in life. White wrote this memoir in 15 separate notebooks, each embossed with "Platner & Porter, Congress" in the upper left-hand corner. Platner & Porter was the manufacturer of the notebooks.

Letter from Thomas Hollis to the Curators of Harvard College, 1762 July 21

Thomas Hollis V (1720-1774), widely known as Thomas Hollis of Lincoln’s Inn, was a very generous donor to Harvard College, particularly its library. This letter, which appears to have accompanied a package, demonstrates that he also donated prints to the College. Hollis wrote: "N.B. the Ludlow, Sydney, Marvell, & Cleopatra are struck on paper made from white & colored silk rags, the produce of premiums of the Society, the noble Society for promoting arts & commerce."

Valedictory address of Jonathan Trumbull, 1762

Four-page manuscript copy of the valedictory Commencement oration composed by Jonathan Trumbull for the 1762 Harvard College Commencement.