Executive Order Number Forty Seven, December 1982

Designate the Office of Planning and Programming as the Governors administrative agent for the Job Training Partnership ACT and the State Job Training Corrdinating Council.

Executive Order Number Forty Eight, January 1983

Provide for the orderly use and development of land related to natural resources.

Executive Order Number Forty Nine, January 1983

Create the Iowa Economic Forecasting Council

Executive Order Number Fifty, January 1983

Proclaim that state agenices shall have certain responsibilities to insure orderly procurement of professional services.

Executive Order Number Two, July 1, 1983

Implement the cooperative network to be called the Assurance Network for Easing Wildwood. (ANEW)

Executive Order Number One, May 8, 1983

Appoint an advisory commission on corrections in Iowa.

Executive Order Number Three, July 1, 1983

Establish a select

Executive Order Number Fifty One, May 19, 1994

Establishes a Library Service Advisory Council.

Alpha1-adrenoceptors are required for normal male sexual function.

BACKGROUND AND PURPOSE: Alpha(1)-adrenoceptor antagonists are extensively used in the treatment of hypertension and lower urinary tract symptoms associated with benign prostatic hyperplasia. Among the side effects, ejaculatory dysfunction occurs more frequently with drugs that are relatively selective for alpha(1A)-adrenoceptors compared with other drugs of this class. This suggests that alpha(1A)-adrenoceptors may contribute to ejaculation. However, this has not been studied at the molecular level. EXPERIMENTAL APPROACH: The physiological contribution of each alpha(1)-adrenoceptor subtype was characterized using alpha(1)-adrenoceptor subtype-selective knockout (KO) mice (alpha(1A)-, alpha(1B)- and alpha(1D)-AR KO mice) since the subtype-specific drugs available are only moderately selective. We analysed the role of alpha(1)-adrenoceptors in the blood pressure and vascular response as well as ejaculation by determining these variables in alpha(1)-adrenoceptor subtype-selective KO mice and in mice with all their alpha(1)-adrenoceptor subtypes deleted (alpha(1)-AR triple-KO mice). KEY RESULTS: The pregnancy rate was reduced by 50% in alpha(1A)-adrenoceptor KO mice, and this reduction was dramatically enhanced in alpha(1)-adrenoceptor triple-KO mice. Contractile tension of the vas deferens in response to noradrenaline was markedly decreased in alpha(1A)-adrenoceptor KO mice, and this contraction was completely abolished in alpha(1)-adrenoceptor triple-KO mice. This attenuation of contractility was also observed in the electrically stimulated vas deferens. CONCLUSIONS AND IMPLICATIONS: These results demonstrate that alpha(1)-adrenoceptors, particularly alpha(1A)-adrenoceptors, are required for normal contractility of the vas deferens and consequent sperm ejaculation as well as having a function in fertility.

Executive Order Number Four, September 3, 1983

Order a 2.8% reduction in appropriations.

Executive Order Number Five, October 25, 1983

Establish gift reporting requirements for the Executive department.

Executive Order Number Six, November 23, 1983

Reafrrim and continue membership in the Upper Mississippi River Basin Assoication.

Executive Order Number Seven, December 16, 1983

Establish the Vietnam Veterans Memorial Commission.

Executive Order Number Eight, January 27, 1984

Eastablish the Iowa Refugee Service Center.

Executive Order Number Nine, February 8, 1984

Appoint all present and future members of the District Export Council to the Governor's Export Advisory Council.