CCL8 and the Immune Control of Cytomegalovirus in Organ Transplant Recipients.

Monitoring of cytomegalovirus cell-mediated immunity is a promising tool for the refinement of preventative and therapeutic strategies posttransplantation. Typically, the interferon-γ response to T cell stimulation is measured. We evaluated a broad range of cytokine and chemokines to better characterize the ex vivo host-response to CMV peptide stimulation. In a cohort of CMV viremic organ transplant recipients, chemokine expression-specifically CCL8 (AUC 0.849 95% CI 0.721-0.978; p = 0.003) and CXCL10 (AUC 0.841, 95% CI 0.707-0.974; p = 0.004)-was associated with control of viral replication. In a second cohort of transplant recipients at high-risk for CMV, the presence of a polymorphism in the CCL8 promoter conferred an increased risk of viral replication after discontinuation of antiviral prophylaxis (logrank hazard ratio 3.6; 95% CI 2.077-51.88). Using cell-sorting experiments, we determined that the primary cell type producing CCL8 in response to CMV peptide stimulation was the monocyte fraction. Finally, in vitro experiments using standard immunosuppressive agents demonstrated a dose-dependent reduction in CCL8 production. Chemokines appear to be important elements of the cell-mediated response to CMV infection posttransplant, as here suggested for CCL8, and translation of this knowledge may allow for the tailoring and improvement of preventative strategies.

Aurora Bertrana : Bringing "otherness" home

“Decidida a viure al preu que sigui” underscores contemporary writer Maria-Antònia Oliver in her prologue to Aurora Bertrana’s fourth book, El Marroc sensual i fanàtic (1936). The urge to travel, to explore the world and to slake her thirst for new experiences shaped much of the personality and the work of this Girona-born writer. Taking her own travels as a starting point, Bertrana distinguished herself in the genre of travel writing on exotic countries, which at that time underwent a significant revival in Catalonia. Bertrana’s originality lies partly in the image of the woman traveller that she consciously cultivated for herself, and partly in the way she narrates her travels. This article seeks to recover this author and make visible her singular way of presenting otherness.

Annales de l'Institut national agronomique : administration, enseignement et recherche

1892 (N15,A20)-1896.

Annales de l'Institut national agronomique : administration, enseignement et recherche

1891 (A16,N14 (DOUBLE))-1892.

Annales de l'Institut national agronomique : administration, enseignement et recherche

1891 (A16,N14)-1892.

Annales de l'Institut national agronomique : administration, enseignement et recherche

1892 (A20,N15)-1896.

Vie de Lalibala, roi d'Ethiopie : texte éthiopien... / [éd.] et trad... par J. Perruchon

Collection : Publications de l'École des lettres d'Alger ; 10

Annales industrielles

1892/01/03 (A24,T1)-1892/05/29.

Annales industrielles

1892/07/03 (A24,T2)-1892/11/27.

Annales industrielles

1892 (A24).

Annuaire du Conseil héraldique de France

1892 (A5).

Arcachon-saison : Journal des étrangers

1892/12/15 (A5,N222)-1892/12/21.

Arcachon-saison : Journal des étrangers

1892/01/14 (A5,N182)-1892/01/20.

Arcachon-saison : Journal des étrangers

1892/11/24 (A5,N219)-1892/11/30.