999 resultados para Donatello i.e. Donato di Niccolò di Betto Bardi, ca. 1386-1466.
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Sin sign.
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Copia digital: Biblioteca valenciana, 2010
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Elevation of cytosolic free Ca2+ concentration ([Ca2+]i) in excitable cells often acts as a negative feedback signal on firing of action potentials and the associated voltage-gated Ca2+ influx. Increased [Ca2+]i stimulates Ca2+-sensitive K+ channels (IK-Ca), and this, in turn, hyperpolarizes the cell and inhibits Ca2+ influx. However, in some cells expressing IK-Ca the elevation in [Ca2+]i by depletion of intracellular stores facilitates voltage-gated Ca2+ influx. This phenomenon was studied in hypothalamic GT1 neuronal cells during store depletion caused by activation of gonadotropin-releasing hormone (GnRH) receptors and inhibition of endoplasmic reticulum (Ca2+)ATPase with thapsigargin. GnRH induced a rapid spike increase in [Ca2+]i accompanied by transient hyperpolarization, followed by a sustained [Ca2+]i plateau during which the depolarized cells fired with higher frequency. The transient hyperpolarization was caused by the initial spike in [Ca2+]i and was mediated by apamin-sensitive IK-Ca channels, which also were operative during the subsequent depolarization phase. Agonist-induced depolarization and increased firing were independent of [Ca2+]i and were not mediated by inhibition of K+ current, but by facilitation of a voltage-insensitive, Ca2+-conducting inward current. Store depletion by thapsigargin also activated this inward depolarizing current and increased the firing frequency. Thus, the pattern of firing in GT1 neurons is regulated coordinately by apamin-sensitive SK current and store depletion-activated Ca2+ current. This dual control of pacemaker activity facilitates voltage-gated Ca2+ influx at elevated [Ca2+]i levels, but also protects cells from Ca2+ overload. This process may also provide a general mechanism for the integration of voltage-gated Ca2+ influx into receptor-controlled Ca2+ mobilization.
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This list appears to be the most comprehensive in this series. Although its contents are very similar to those of the list in Folder 2, there are some discrepancies. Entries are arranged by format (folio, quarto, octavo) and include the date the book was "delivered" (loaned), the name of the individual who borrowed it, and its author, title, and volume number. Many of the books had been out of the library for decades prior to the fire, with some loaned out since as early as 1742.
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This list appears to be a draft of the list in Folder 1. Although most of the entries match, there are some discrepancies.
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This list appears to be in the hand of Andrew Eliot, Librarian from 1763 to 1767. Books are listed according to format (folio, quarto, octavo) and entries indicate the surname of the student who checked the book out, its author and title, and whether or not the book had since been "returned and sent down." Some entries indicate unusual locations, including "says he returned it to the Pres[ident]" and "Dr. Marsh has it."
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Lists books borrowed by those with surnames Wyeth, Goodhue, Eliot, Langdon, Adams, Apthorp, Bowdoin, Chardon, and Mayhew. Entries include format, title, author, and volume number. Written in multiple hands.
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Lists books borrowed by many individuals, including Governor William Shirley, Colonel Brinley, General Brattle, Secretary Willard, Judge Danforth, Colonel Wendell, Thomas Oliver, Christ Bridge Marsh, and Francis Foxcroft. Entries include the author and title of the borrowed volumes.
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This layer is a georeferenced raster image of the historic paper map entitled: Descriptio agri civitatis Coloniensis : cum suis limitibus, terminis, viis, confiniis, interjacentibus, et adjacentibus pagis, villis, castris etc. It was published by I. Cóvens et C. Mortier in 1735. Scale [ca. 1:60,000]. Covers the Cologne region, Germany. Map in Latin. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Deutsches Hauptdreiecksnetz (DHDN) 3-degree Gauss-Kruger Zone 2 coordinate system. All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, towns and villages, drainage, built-up areas, fortification, ground cover, and more. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection as part of the Imaging the Urban Environment project. Maps selected for this project represent major urban areas and cities of the world, at various time periods. These maps typically portray both natural and manmade features at a large scale. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.
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Mode of access: Internet.
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Mode of access: Internet.
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Thesis (Ph.D.)--University of Washington, 2016-06