Fiscal Update, April 10, 2006

The Fiscal Division newsletter, published weekly during session and periodically during the interim.

Transmission of HIV-1 drug resistance in Switzerland: a 10-year molecular epidemiology survey.

OBJECTIVES: Representative prevalence data of transmitted drug-resistant HIV-1 are essential to establish accurate guidelines addressing resistance testing and first-line treatments. METHODS: Systematic resistance testing was carried out in individuals in Switzerland with documented HIV-1 seroconversion during 1996-2005 and available samples with RNA > 1000 copies/ml obtained within 1 year of estimated seroconversion. Resistance interpretation used the Stanford list of mutations for surveillance of transmitted drug resistance and the French National Agency for AIDS Research algorithm. RESULTS: Viral sequences from 822 individuals were available. Risk groups were men having sex with men (42%), heterosexual contacts (32%) and intravenous drug users (20%); 30% were infected with non-B subtype viruses. Overall, prevalence of transmitted resistance was 7.7% [95% confidence interval (CI), 5.9-9.5] for any drug, 5.5% (95% CI, 3.9-7.1) for nucleoside reverse transcriptase inhibitors, 1.9% (95% CI, 1.0-2.8) for non-nucleoside reverse transcriptase inhibitors and 2.7% (95% CI, 1.6-3.8) for protease inhibitors. Dual- or triple-class resistance was observed in 2% (95% CI, 0.8-2.5). No significant trend in prevalence of transmitted resistance was observed over years. There were no differences according to ethnicity, risk groups or gender, but prevalence of transmitted resistance was highest among individuals infected with subtype B virus. CONCLUSIONS: The transmission rate of drug-resistant HIV-1 has been stable since 1996, with very rare transmission of dual- or triple-class resistance. These data suggest that transmission of drug resistance in the setting of easy access to antiretroviral treatment can remain stable and be kept at a low level.

Secure and Prepared Newsletter, June 26, 2007, Vol. 3, no. 10

A bi-weekly newsletter for those involved in the fields of homeland security and/or emergency management

Secure and Prepared Newsletter, July 10, 2007, Vol. 3, no. 11

A bi-weekly newsletter for those involved in the fields of homeland security and/or emergency management

Secure and Prepared Newsletter, July 9, 2008, Vol. 4, no. 10

A bi-weekly newsletter for those involved in the fields of homeland security and/or emergency management

Secure and Prepared Newsletter, May 21, 2009, Vol. 5, no. 10

A bi-weekly newsletter for those involved in the fields of homeland security and/or emergency management

Secure and Prepared Newsletter, September 10, 2009, Vol. 5, no. 18

A bi-weekly newsletter for those involved in the fields of homeland security and/or emergency management

Footnotes, October, November, December 2009, Vol.34, no.10-12

Monthly newsletter of State Library

Iowa Community Empowerment Newsletter, December 2009, Vol 10, no. 5

Monthly newsletter for the Iowa Department of Public Health

Iowa Developments, December 2009, Vol 10, no.6

Iowa Business Development News from the Iowa Department of Economic Development

Business Recovery Status Report #10: Presidential Disaster #1763, September 12, 2008

Safeguard Iowa Partnership launched a survey to the business community to capture the impact from the 2008 disasters. Five hundred eighty surveys were completed and compiled for the report submitted to the Rebuild Iowa Office Economic and Workforce Development Task Force on August 20, 2008.

Business Recovery Status Report #14: Presidential Disaster #1763, October 10, 2008

Safeguard Iowa Partnership launched a survey to the business community to capture the impact from the 2008 disasters. Five hundred eighty surveys were completed and compiled for the report submitted to the Rebuild Iowa Office Economic and Workforce Development Task Force on August 20, 2008.