Screening of Indian Plants for Biological Activity : Part IX

Two hundred and ninety three botanically identified plant materials have been tested as 50% ethanol extracts, for a wide variety of biological activities including antifertility, anticancer, chemotherapeutic and pharmaceutical activities. Biological activity has been confirmed in fractions of 40 of these extracts.

Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen.

Thrombospondin-5 (TSP5) is a large extracellular matrix glycoprotein found in musculoskeletal tissues. TSP5 mutations cause two skeletal dysplasias, pseudoachondroplasia and multiple epiphyseal dysplasia; both show a characteristic growth plate phenotype with retention of TSP5, type IX collagen (Col9), and matrillin-3 in the rough endoplasmic reticulum. Whereas most studies focus on defining the disease process, few functional studies have been performed. TSP5 knockout mice have no obvious skeletal abnormalities, suggesting that TSP5 is not essential in the growth plate and/or that other TSPs may compensate. In contrast, Col9 knockout mice have diminished matrillin-3 levels in the extracellular matrix and early-onset osteoarthritis. To define the roles of TSP1, TSP3, TSP5, and Col9 in the growth plate, all knockout and combinatorial strains were analyzed using histomorphometric techniques. While significant alterations in growth plate organization were found in certain single knockout mouse strains, skeletal growth was only mildly disturbed. In contrast, dramatic changes in growth plate organization in TSP3/5/Col9 knockout mice resulted in a 20% reduction in limb length, corresponding to similar short stature in humans. These studies show that type IX collagen may regulate growth plate width; TSP3, TSP5, and Col9 appear to contribute to growth plate organization; and TSP1 may help define the timing of growth plate closure when other extracellular proteins are absent.

Commentary of GATS Article IX : Business Practices

Commentary of Article IX of the General Agreement on Trade in Services (GATS) on business practices, including a textual analysis of the provision, as well as an examination of the pertinent WTO case law and of other related international and regional rules and practices.

Uma carta de lei inédita de D. Alfonso V. onde, entre outros assuntos, se trata das judiaras portuguesas

[von] Mosés Bensabat Amzalak

Indirizzo della deputazione israelitica di Roma a nostro signore Papa Pio IX., nell'udienza sovrana accordatale il giorno 10 gennaro 1848

Aus: La Speranza ; N. 10

Alcuni pensieri sopra gli atti di beneficenza del ... papa Pio IX. ... verso gli Ebrei di Roma ... ovvero L'ebraismo in Roma e nell'impero innanzi e dopo l'era volgare : div. in 3 diss. dell' ...

Luigi Vincenzi ; con app. allo scritto di Massimo d'Azeglio sull'emancipazione degl'israeliti

Corpus inscriptionum Hebraicarum enthaltend Grabschriften aus der Krim und andere Grab- und Inschriften in alter hebräischer Quadratschrift sowie auch Schriftproben aus Handschriften vom IX. - XV. Jahrhundert

ges. u. erl. von D. Chwolson. Mit 4 photolithogr. u. 2 phototyp. Taf. nebst e. Schrifttaf. von [Julius] Euting

Abramo Colorni : ingegnere i Alfonso II. d'Este ; memoria letta nell' adunanza 30 marzo 1890

nuove ricerche del G. Jarè