993 resultados para Bassett, Leslie, 1923-
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En la actualidad está de moda intentar definir al "individuo medio", al "trabajador medio", etc., mediante la prospección estadística de determinadas catas de la sociedad que deben darnos, teòricamente, una visión más o menos objetiva de la realidad que nos interesa conocer. [. . .]
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Collection : Les actrices du XVIIIe siècle
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Antiresorptive agents such as bisphosphonates induce a rapid increase of BMD during the 1st year of treatment and a partial maintenance of bone architecture. Trabecular Bone Score (TBS), a new grey-level texture measurement that can be extracted from the DXA image, correlates with 3D parameters of bone micro-architecture. Aim: To evaluate the longitudinal effect of antiresorptive agents on spine BMD and on site-matched spine microarchitecture as assessed by TBS. Methods: From the BMD database for Province of Manitoba, Canada, we selected women age >50 with paired baseline and follow up spine DXA examinations who had not received any prior HRT or other antiresorptive drug.Women were divided in two subgroups: (1) those not receiving any HRT or antiresorptive drug during follow up (=non-users) and (2) those receiving non-HRT antiresorptive drug during follow up (=users) with high adherence (medication possession ratio >75%) from a provincial pharmacy database system. Lumbar spine TBS was derived by the Bone Disease Unit, University of Lausanne, for each spine DXA examination using anonymized files (blinded from clinical parameters and outcomes). Effects of antiresorptive treatment for users and non-users on TBS and BMD at baseline and during mean 3.7 years follow-up were compared. Results were expressed % change per year. Results: 1150 non-users and 534 users met the inclusion criteria. At baseline, users and non-users had a mean age and BMI of [62.2±7.9 vs 66.1±8.0 years] and [26.3±4.7 vs 24.7±4.0 kg/m²] respectively. Antiresorptive drugs received by users were bisphosphonates (86%), raloxifene (10%) and calcitonin (4%). Significant differences in BMD change and TBS change were seen between users and nonusers during follow-up (p<0.0001). Significant decreases in mean BMD and TBS (−0.36± 0.05% per year; −0.31±0.06% per year) were seen for non-users compared with baseline (p<0.001). A significant increase in mean BMD was seen for users compared with baseline (+1.86±0.0% per year, p<0.0018). TBS of users also increased compared with baseline (+0.20±0.08% per year, p<0.001), but more slowly than BMD. Conclusion: We observed a significant increase in spine BMD and a positive maintenance of bone micro-architecture from TBS with antiresorptive treatment, whereas the treatment naïve group lost both density and micro-architecture. TBS seems to be responsive to treatment and could be suitable for monitoring micro-architecture. This article is part of a Special Issue entitled ECTS 2011. Disclosure of interest: M.-A. Krieg: None declared, A. Goertzen: None declared, W. Leslie: None declared, D. Hans Consulting fees from Medimaps.
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L’article analitza les causes que van propiciar la traducció al català d’un clàssic del preciosisme francès del xvii, com a resultat de l’establiment de la Mancomunitat de Catalunya, a principi del xx, i amb l’eclosió del noucentisme, moviment artístic que va promoure traduccions de la literatura universal amb l’objectiu d’assajar la configuració d’un llenguatge literari modern propi. Estudia la primera versió catalana de La Princesse de Clèves (1678) de Madame de La Fayette, deguda a Rafel Marquina i publicada el 1923, i la que s’hi va afegir el 1990, que és la retraducció que n’ofereix Josep A. Grimalt, lingüísticament més actual, transparent i més lliure d’artificis noucentistes. Tots dos traductors, això no obstant, són fidels al sentit, al to i a l’estil d’un text que representa l’entrada de la dona, en qualitat d’autora i de protagonista, a la novel·la moderna.