980 resultados para BCR-ABL ONCOGENE


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Component natural remanent magnetizations derived from u-channel and 1-qcm discrete samples from ODP Site 919 (Irminger Basin) indicate the existence of four intervals of negative inclinations in the upper Brunhes Chronozone. According to the age model based on planktic oxygen isotope data, these "excursional" intervals occur in sediments deposited during the following time intervals: 32-34 ka, 39-41 ka, 180-188 ka and 205-225 ka. These time intervals correspond to polarity excursions detected elsewhere, known as Mono Lake, Laschamp, Iceland Basin and Pringle Falls. The isotope-based age model is supported by the normalized remanence (paleointensity) record that can be correlated to other calibrated paleointensity records for the 0-500 ka interval, such as that from ODP Site 983. For the intervals associated with the Mono Lake and Laschamp excursions, virtual geomagnetic poles (VGPs) reach equatorial latitudes and mid-southerly latitudes, respectively. For intervals associated with the Iceland Basin and Pringle Falls excursions, repeated excursions of VGPs to high southerly latitudes indicate rapid directional swings rather than a single short-lived polarity reversal. The directional instability associated with polarity excursions is not often recorded, probably due to smoothing of the sedimentary record by the process of detrital remanence (DRM) acquisition.

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We report an optimized method for extracting neodymium (Nd) from fossil fish teeth with a single-stage column (125 µl stem volume; LN Resin, Eichrom Industries, Darien Illinois) for isotopic analysis by multi-collector inductively coupled mass spectrometry (MC-ICMPS). Three reference materials (basalt: BCR-2, BHVO-2; phosphate: fossil bone composite) and splits of fossil fish teeth samples previously processed with existing two-stage column methods were processed using the single-stage column method. 143Nd/144Nd values of reference materials agree within error with published values, and the values for fish teeth correspond with sample splits processed with two-stage columns. Precision to ± ~0.23 epsilon-Nd was achieved for 30 ng Nd samples of reference materials, and Nd isotope measurements of fossil fish tooth sample replicates as small as 7 ng Nd were reproducible within long term instrumental uncertainty. We demonstrate the utility of the new method with the first high resolution Nd isotope record spanning the ~40.0 Ma middle Eocene Climatic Optimum, which shows an excursion of 0.65 epsilon-Nd during the peak warming at the study site (Ocean Drilling Program Leg 119, Site 738; 30 kyr sample spacing from 40.3 to 39.6 Ma). LN Resin is already used in standard methods for separating Nd, and Nd isotopes are routinely measured by MC-ICPMS with high efficiency inlet systems. Our innovation is a single, small volume LN Resin column for Nd separation. The streamlined approach results in a 10X increase in sample throughput.

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The basalts in Holes 519A, 522B, and 524 were studied for intensity of natural remanent magnetization, magnetic hysteresis, magnetic susceptibility, stability of isothermal remanence, and thermomagnetic behavior. Some of these properties are sensitive to both the composition and the microstructure of the magnetic minerals, others to composition only. Thus it is possible to separate the two effects and to trace the variation of effective magnetic grain size and degree of alteration within a lithologic unit or over a yet larger distance or time interval. The flow in Hole 519A is highly maghemitized at the top, the degree of maghemitization decreasing with depth in the flow. Effective grain size increases with increasing depth. Electron microprobe analysis of the titanomaghemite grains in these samples provides no support for the leaching out of iron during alteration. The pillows and flows in Hole 522B are distributed among a number of cooling units, and no systematic downhole variations are apparent. The inferred magneto-petrology is consistent with the cooling and alteration history that might be expected within the units. The upper and lower sills in Hole 524 are more uniform and have a larger concentration of well-developed magnetic mineral grains than the pillows and flows in Holes 519A and 522B. Maghemitization appears to have developed from the boundaries of the sills that are in contact with the sediments between the sills.

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D18O values of nine tropical-subtropical planktonic foraminiferal species with different preferential habitat depths collected from 62 core-top samples along an east-west transect across the tropical Atlantic/Caribbean were used to test the applicability of interspecific d18O gradients for reconstructions of tropical upper ocean stratification. In general, the d18O difference (Delta d18O) between intermediate- and shallow-dwelling species decreases, and Delta d18O between deep and intermediate dwellers increases with increasing thermocline depth towards the west. The statistical significance of regional differences in Delta d18O highlights Delta d18O between the intermediate dwellers (in particular Globorotalia scitula and Globorotalia tumida) and the shallow dweller Globigerinoides ruber pink, as well as Delta d18O between the deep dwellers Globorotalia crassaformis or Globorotalia truncatulinoides dextral and intermediate dwellers as most sensitive to changes in tropical Atlantic thermocline depth. Based on the observed regional variations in interspecific Delta d18O, we propose a multispecies stratification index "STRAtrop" = (d18Ointermediate - d18Oshallow) / (d18Odeep - d18Oshallow) for the tropical ocean. Statistically significant differences in STRAtrop values between the E-Atlantic and the Caribbean suggest that this index may be a useful tool to monitor variations in tropical upper ocean stratification in the geological record.

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This work is the first detailed description of the Late Pleistocene-Holocene and Recent Ostracoda of the Laptev Sea. A total of 45 species in 22 genera and 13 families have been identified. All these species are described monographically. Three different ecological assemblages of ostracodes corresponding to different combinations of environmental parameters have been established; they are restricted to three regions of the sea: western-central, eastern, and southern. The recent ostracode assemblages of the Laptev Sea have been compared with those from other Arctic areas and are most similar to those of the Beaufort and Kara seas. Data on recent Ostracoda are used for paleoenvironmental reconstructions on the eastern shelf and western continental slope of the Laptev Sea. For this purpose, ostracodes from five sections obtained from these parts of the sea have been examined. The oldest sediments, which are of Late Pleistocene age (15.8 cal. ka BP), have been recovered in a core from the western continental slope. These yielded five ostracode assemblages, which correspond to different paleoenvironments and replaced each other in the course of the rapid postglacial sea-level rise, thus showing variations in the Atlantic water inflow from the west and freshwater discharge from the subaerially exposed shelf. On the outer shelf of the eastern part of the sea, the rapid sea-level rise in the Early Holocene (lowermost dating 11.3 cal. ka BP) led to a rapid transition from assemblages of brackish-water nearshore environments to those of modernlike normal marine environments; modern environments were established about 8.2 cal. ka ago. Since core sections from the inner shelf correspond to the time when the level of the sea had already reached its modern values, changes in taxonomic composition of ostracode assemblages primarily mirror variations in river runoff.

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Over 100 samples of recent surface sediments from the bottomn of the Atlantic Ocean offshore NW Africa between 34° and 6° N have been analysed palynologically. The objective of this study was to reveal the relation between source areas, transport systems, and resulting distribution patterns of pollen and spores in marine sediments off NW Africa, in order to lay a sound foundation for the interpretation of pollen records of marine cores from this area. The clear zonation of the NW-African vegetation (due to the distinct climatic gradient) is helpful in determining main source areas, and the presence of some major wind belts facilitates the registration of the average course of wind trajectories. The present circulation pattern is driven by the intertropical front (ITCZ) which shifts over the continent between c. 22° N (summer position) and c. 4° N (winter position) in the course of the year. Determination of the period of main pollen release and the average atmospheric circulation pattern effective at that time of the years is of prime importance. The distribution patterns in recent marine sediments of pollen of a series of genera and families appear to record climatological/ecological variables, such as the trajectory of the NE trade, January trades, African Easterly Jet (Saharan Air Layer), the northernmost and southernmost position of the intertropical convergence zone, and the extent and latitudinal situation of the NW-African vegetation belt. Pollen analysis of a series of dated deep-sea cores taken between c. 35° and the equator off NW African enable the construction of paleo-distribution maps for time slices of the past, forming a register of paleoclimatological/paleoecological information.

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Manganese nodules research has focused on the area between the Clarion Fracture Zone to the North and the Clipperton Fracture Zone to the South where significant concentrations were found ni Ni-Cu. During the CCOP/SOPAC-IOC/IDOE International workshop on the "Geology Mineral Resources and Geophysics of the South Pacific" held in Fiji in September 1975, a working group on manganese nodules was formed by scientists from: CNEXO, Brest, the Institute of Oceanography, New Zealand, Imperial College, London and the Technical University of Aachen. A draft project was presented in July 1976 by J. Andrews, University of Hawaii and G. Pautot, Cnexo on a joint survey under the name of: "Hawaii-Tahiti Transect program". Further details were worked on in September 1976 during the International Geological Congress in Sydney with the participation of D. Cronan, Imperial College, Glasby, New Zealand Geological Survey and G. Friedrich, Aachen TU. The scientific final program was established in July 1977, planning on the participation of three research vessels: the Suroit (CNEXO), the Kana Keoki (U. of Hawaii) and the Sonne (Aachen TU). Several survey areas were selected across the Pacific Ocean (Areas A, B, C, D, E, F, G and H) with about the same crustal age (about 40 million years) and a similar water depths. Being near large fault zones, the ares would be adequate to study the influences of biological productivity, sedimentation rate and possibly volcanic activity on the formation and growth of manganese nodules. The influnece of volcanic activity study would particularly apply to area G being situated near the Marquesas Fracture Zone. The cruise from R/V Sonne started in August 1978 over areas C, D, F, G K. The R/V suroit conducted a similar expedition in 1979 over areas A, B, C, D, E, H and I. Others cruises were planned during the 1979-1980 for the R/V Kana Keoki. The present text relates the R/V Sonne Cruises SO-06/1 and SO-06/2 held within the frame work of this international cooperative project.