Avaliação da qualidade de comprimidos de captopril 50 mg comercializados no Brasil

O captopril foi o primeiro agente desenvolvido para o tratamento da hipertensão, doença que acomete grande parte da população adulta mundial, a qual requer cuidados especiais quanto à farmacoterapia e ajuste de doses. Assim sendo, este trabalho tem como objetivo avaliar a qualidade de comprimidos de captopril 50 mg comercializados no Brasil através da realização da equivalência farmacêutica entre duas marcas de comprimidos não revestidos de captopril 50 mg (um genérico G e um similar S) em relação ao medicamento referência (R) Capoten® Bristol Myers Squibb 50 mg, utilizando os requisitos descritos na monografia individual do fármaco da Farmacopeia Brasileira e da Farmacopeia Americana. Medicamentos referência são produtos inovadores, cuja eficácia, segurança e qualidade foram comprovadas cientificamente; os chamados similares são os que contêm as mesmas substâncias ativas, mesma concentração, forma farmacêutica, via de administração, posologia e indicação terapêutica do medicamento de referência e são identificados por nome comercial ou por sua marca; os medicamentos genéricos são intercambiáveis com o produto referência e, geralmente, são produzido após a expiração ou renúncia da proteção patentária do mesmo, ele deve ser designado pela DCB (Denominação Comum Brasileira) ou, na ausência desta, pela DCI (Denominação Comum Internacional). Os dois medicamentos analisados, medicamento similar e medicamento genérico, apresentaram resultados satisfatórios quanto à determinação de peso médio, resistência mecânica e tempo de desintegração dos comprimidos, identificação, doseamento, limite de dissulfeto de captopril, uniformidade de doses unitárias, teste de dissolução e perfil de dissolução do fármaco, com relação ao seu medicamento referência correspondente, ou seja, estes são equivalentes farmacêuticos e apresentam qualidade... (Resumo completo, clicar acesso eletrônico abaixo)

Oferta educacional nas creches e parcerias público-privado nos municípios paulistas de 10.001 a 50.000 habitantes

Este trabalho, foi realizado como Trabalho de Conclusão de Curso e Iniciação Científica. Este identifica, caracteriza e analisa, no conjunto dos municípios paulistas de 10.001 a 50.000 habitantes, os diferentes arranjos institucionais firmados entre o Poder Público Municipal e instituições privadas para a oferta educacional em creches. O período considerado para o presente estudo foi entre 2000 e 2009. O início do período em 2000 se justifica pelo prazo final estabelecido pela LDB 9394/96 para integração das creches aos respectivos sistemas de ensino ser dezembro de 1999. O estudo realizado nos permitiu observar a manutenção dos convênios firmados entre o Poder Público Municipal e instituições privadas sem fins lucrativos. As justificativas utilizadas para esclarecer a opção municipal pelo convênio com instituições que oferecem vagas à crianças de 0 a 3 anos, se voltarão para atender a demanda existente no município que este não consegue suprir e auxílio financeiro à instituição que oferece o atendimento a tempos no município. Outro fato que podemos constatar foi o que um número considerável que municípios cadastram as matrículas das entidades privadas conveniadas com o poder público, como matrículas públicas. Utilizamos como procedimento teórico-metodológico o levantamento e análise bibliográfica, contatos telefônicos diretos com os gestores municipais para coletar informações sobre as parcerias, dados disponibilizados no Banco de Dados do Grupo de Estudos e Pesquisas em Política Educacional (GREPPE), sites oficiais dos municípios e sites governamentais. Constitui-se este trabalho como parte integrante da pesquisa “Oferta Educacional nas creches: Arranjos Institucionais entre o Público e o Privado” financiada pelo CNPq e coordenada pela Profª Drª Raquel Fontes Borghi

Comparando a eficácia da manta térmica com método de aquecimento passivo na prevenção de hipotermia

Hypothermia is a common phenomenon in the perioperative period, and it affects 60 to 90% of patients submitted to anesthetic-surgical procedures. In order to minimize its incidence, warming methods are used. Such methods can be passive, such as orthopedic cotton, sheets and blankets, or active, such as warm-air blankets and thermal mattresses. In this scenario, the present study aimed at comparing two warming methods used in the intraoperative period. Patients submitted to abdominal surgery in the specialties of gynecology and gastric surgery from August to September 2010 were included in the study. After randomization, they were divided into two groups: one using a thermal blanket (group I) and one using orthopedic cotton (group II). At last, 9 patients were included. The variables for each question were considered according to occurrence frequency. Comparison between groups was performed by Student’s t test. With the purpose to analyze whether there was an association, the chi-square test or Fisher’s Exact test was used. Whenever it was applicable for multiple comparisons, Tukey’s test was utilized; p values < 0.05 were considered to be statistically significant for analysis. The sample comprised 6 males and 3 females submitted to gynecological and gastric surgeries. Their mean age was 48 years for group I and 46.2 years for group II. A predominance of general anesthesia was observed. The time of permanence in the operating room ranged from 80 to 360 minutes. With regard to warming parenteral solutions, the procedure was performed on 5 patients, and infusion of warm solution into the abdominal cavity was performed on 50% of the sample. Concerning the warming method used, 5 patients used a thermal blanket. In view of the results presented, it was not possible to conclude which warming method should be used due to sample size

Mapeamento geológico, caracterização litoquímica e potencial econômico do corpo de cromitito de Cedrolina, Santa Terezinha de Goiás - GO

Studies of mafic-ultramafic bodies have been carried out through the years due to their great use on the interpretation of geochemical and geotectonic processes that took place in Earth's history. Amongst them, chromitites are notably recognized for being excellent indicators of their parental magma chemistry and of different geotectonic environments, as well for frequently containing associated noble metals mineralization. Thus the investigation of one of this ultramafic bodies that occurs inside the Pilar de Goiás Greenstone Belt was proposed, resulting in a detailed map of the chromitites and country rocks, as well as innumerous new data on the chemistry of chromite and associated matrix and accessory minerals. These studies were based upon geological field observations, optic and Scanning Electron Microscope (SEM), besides electron microprobe and cathodoluminescence analysis performed at the “Eugen F. Stumpfl Laboratory” of the Montanuniversität Institute of Resource Mineralogy, University of Leoben - Leoben, Austria. The chromitites are composed of 40-70% in volume of chromite (~50% on average), 14-55% of talc (~30% on average), 3-60% of chromium rich chlorite (~20% on average), traces to 4% of iron hydroxides and traces to 3% of rutile (1,5% on average). The chromite occurs as large spherical aggregates or as fine grained subhedral crystals disseminated in the matrix. This aggregates have diameters of 0.3-1.5 cm (1 cm on average) and are extremely well rounded, massive to intensively fractured, and commonly deformed to ellipsoids. When observed under the microscope, these aggregates show well rounded to slightly irregular borders, but on their interiors, these structures are represented by fine to medium grained euhedral to subhedral chromite crystals that have sharp contacts between themselves. The rock's matrix is basically made of chlorite and talc that define a metamorphic foliation (Sn), being the talc an alteration product ...

Modelos de tratamento para adenocarcinomas de próstata tratados por radioterapia conformacional 3D

Radiotherapy is a branch of medical physics related to the treatment of malignant neoplasm, being an important instrument in the fight against cancer, when combined with the effort of a multidisciplinary team, composed of, physicians, physicists, nurses and technicians. Every year more than 3.5 million new cases of cancer are recorded in the world, being the prostate cancer responsible for approximately 25% of this amount (INCA and IARC, 2008). In this type of cancer, radiotherapy is a method indicated for treatement. The technological advance in this area over years has allowed a greater accuracy in the tumor location, more conformation of the radiation beam around the tumor, reducing the dose in healthy tissues and a consequent dose increase on treatment (Bedford et al., 1999). A radiotherapy planning, in which the physicist develops an important role, is composed of several steps, including choosing the best configuration of treatment beams. This choice has a close relationship with success of therapy and is critical to achieve the best distribution of dose inside the tumor and expose the least as possible the healthy tissue to radiation. In this work, two options for setting up camps in the first phase in a treatment of prostate cancer were simulated in computer planning: 4 fields orthogonal or “Box” with gantry angles in 00, 1800, 2700 e 90° and 4 fields angled or “X” (1350, 450, 3150 e 2250). The percentage of the rectal volume exposed to 40, 50, 60, 72 and 76 Gy should be limited to 60, 50, 25, 15 and 5% respectively (Greco et al., 2003). The femoral toxicity have limited dose by 70% of the total dose prescribed in a prostate treatment (Bedford et al., 1999). The planning of 27 patients with prostate adenocarcinoma submitted to 3D conformal radiotherapy were accompanied. As a result, it was assessed that the best TCP (tumor control probability)... (Complete abstract click electronic access below)

Produção de carvão vegetal a partir da madeira de Eucalyptus saligna clone SI70 com tres anos e meio de idade

Charcoal is obtained from carbonization, much used in the steel industry for ore reduction, using as raw material the Eucalyptus. The present study aims to verify whether the main Eucalyptus saligna genetically modified produce quality charcoal with only 3.5 years old. The study was done with material collected from three trees, divided into five discs removed at 0, 25 , 50 , 75 and 100 % of the commercial height of the tree. The procedures adopted were based on standards published by ABNT. The results were satisfactory for the parameters: basic wood density with an average of 0.39 ± 0.0082 g / cm ³; volatile materials from coal with an average of 19.35 ± 3.27 %, fixed carbon content of the coal with an average of 75.62 ± 3.40 % and gross calorific value of coal with an average of 4694.43 cal / g, and unsatisfactory results for ash content averaging 5.03 ± 0.23 when compared to the values found in the literature. It was concluded that the studied wood is able to produce charcoal, but the factors of production should be better observed, such as heating time which exerted direct influence on the determination of ash content

Indicadores Antropométricos do Estado Nutricional de Idosas Praticantes e Não Praticantes de Exercício Fisíco na Zona Norte de São José do Rio Preto-SP

Although the regular practice of physical exercise for the maintenance of the nutritional state and quality of life is important, it is not a common habit among the elderly, especially those of the lower income social bracket. The objective was to characterize and compare according to social-economic conditions and anthropometric indexes of the nutritional state of the elderly who regularly practice and those who do not practice exercises, offered at no cost, in the Northern zone of São José do Rio Preto-SP. In this study, 110 elderly women participated, of which 60 (group P) exercised regularly and 50 did not (group NP). Group P participated in a special gym program, free of charge, for at least 2 years, 2 to 3 times a week, one hour a day. Group NP was recruited from the same location as Group P. The comparison between the groups of elderly women was proportionately distributed according to marital status, level of education, means of locomotion, results of body mass index (IMC), waist to hip ratio (RCQ) and calf circumference, using the chi-square test. Comparisons were also made of average age, per capita family income, individual income, IMC, arm and triceps skin fold measured by t-Test. Differences were not found in all the comparisons made. The variables that stood out were the IMC (overweight) and RCQ (risk of chronic diseases) results, which were above what was expected, and the high frequency of walking and riding buses for both groups of elderly women (about 60%). We came to the conclusion that the low-intensity exercise program evaluated made no difference in the nutritional profile of the elderly who also used walking as a means of getting around.

Análise ultrassonográfica qualitativa e quantitativa da deglutição orofaríngea

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo do remodelamento da lâmina própria da laringe relacionado ao processo de senilidade

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Compósitos de nanocelulose / PHBV: manta microfibrilica por eletrofiação

Pós-graduação em Engenharia Mecânica - FEG

Avaliação da prevalência das doenças peri-implantares e do sucesso e sobrevivência de implantes osseointegrados com 8 a 10 anos de função

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Fatores prognósticos para o abandono precoce do tratamento da dependência do álcool, crack e outras drogas em uma comunidade terapêutica

Pós-graduação em Saúde Coletiva - FMB

O cruzeiro: acontecimento e rotina como forma de vida da mulher nos anos 1950

Magazines such as O Cruzeiro are part of the Brazilian collection. In its pages, the female presence is constant. From the concepts of Greimas’ way of life and happening and routine from Zilberberg, we analyse a photoreport which highlights the actress Ilka Soares, comparing her to texts of the session “To the woman”. The analysis of such texts lets us verify the behaviour of a distinguished professional which is different from the traditional model of the housewife of the fifties. Reconstitute the ways of life of these women is to make up for the memory of the country

Burnout em dentistas do serviço público: ter ou não ter, eis a questão!

Objective: the objective of this study was to estimate the prevalence of Burnout Syndrome in dentists in the public service in the city of Araraquara – SP and its association with the variables of interest. Material and method: The sample was made up of the dentists active in the public health network (n = 60). Socio-demographic data was collected. The Oldenburg Burnout Inventory (OLBI) was used. Result: Of the participants, 60.0% were female and the average age was 41.9 ± 7.6 years. A large number of the professionals displayed a normal perception of the work conditions, premises, materials and equipment. 63.3% of the individuals feel tired even before arriving for work, 58.3% need more time to relax and to feel better, 70.0% are unable to deal well with the pressures of work, 50.0% feel they have no energy during or after work and 86.7% do not consider the work to be a positive challenge. It was observed that 48.3% of dentists displayed Burnout Syndrome, 11.7% Detachment and 13.3% Exhaustion. There was a significant association between the presence of Burnout and gender (p = 0.020) and the work premises (p = 0.011), with men being the most affected and those that considered the work premises very poor. Conclusion: It was concluded that the prevalence of Burnout Syndrome among dentists is high, with men and those who consider the work premises bad being the most affected.

Cinética do consumo de oxigênio e tempo limite na vvo2max: comparação entre homens e mulheres

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)