Voyage autour du monde sur la frégate "la Vénus" pendant les années 1836-1839. Tome 9 / , publié... par Abel Du Petit-Thouars,...

Comprend : Botanique ; Zoologie... Oiseaux... ; Zoologie... Reptiles... ; Physique... ; Zoologie... Poissons ; Zoologie... Oiseaux... ; Zoologie. Mammifères

ABD Promos, September 2013, Vol. 13, no. 9

The ABD Promos Newsletter is produced monthly and details Division announcements, holiday schedules, broker promotions and a newly listed codes clipout section, which is formatted to be stapled into the Iowa Liquor Quarterly Spirits Price Book.

ABD Promos, September 2012, Vol. 12, no. 9

The ABD Promos Newsletter is produced monthly and details Division announcements, holiday schedules, broker promotions and a newly listed codes clipout section, which is formatted to be stapled into the Iowa Liquor Quarterly Spirits Price Book.

Polymorphisms in toll-like receptor 4 and toll-like receptor 9 influence viral load in a seroincident cohort of HIV-1-infected individuals.

OBJECTIVES: Toll-like receptors (TLRs) are innate immune sensors that are integral to resisting chronic and opportunistic infections. Mounting evidence implicates TLR polymorphisms in susceptibilities to various infectious diseases, including HIV-1. We investigated the impact of TLR single nucleotide polymorphisms (SNPs) on clinical outcome in a seroincident cohort of HIV-1-infected volunteers. DESIGN: We analyzed TLR SNPs in 201 antiretroviral treatment-naive HIV-1-infected volunteers from a longitudinal seroincident cohort with regular follow-up intervals (median follow-up 4.2 years, interquartile range 4.4). Participants were stratified into two groups according to either disease progression, defined as peripheral blood CD4(+) T-cell decline over time, or peak and setpoint viral load. METHODS: Haplotype tagging SNPs from TLR2, TLR3, TLR4, and TLR9 were detected by mass array genotyping, and CD4(+) T-cell counts and viral load measurements were determined prior to antiretroviral therapy initiation. The association of TLR haplotypes with viral load and rapid progression was assessed by multivariate regression models using age and sex as covariates. RESULTS: Two TLR4 SNPs in strong linkage disequilibrium [1063 A/G (D299G) and 1363 C/T (T399I)] were more frequent among individuals with high peak viral load compared with low/moderate peak viral load (odds ratio 6.65, 95% confidence interval 2.19-20.46, P < 0.001; adjusted P = 0.002 for 1063 A/G). In addition, a TLR9 SNP previously associated with slow progression was found less frequently among individuals with high viral setpoint compared with low/moderate setpoint (odds ratio 0.29, 95% confidence interval 0.13-0.65, P = 0.003, adjusted P = 0.04). CONCLUSION: This study suggests a potentially new role for TLR4 polymorphisms in HIV-1 peak viral load and confirms a role for TLR9 polymorphisms in disease progression.

Secure and Prepared Newsletter, December 2013, Vol. 9, no. 12

A bi-weekly newsletter for those involved in the fields of homeland security and/or emergency management

Farm Families Alive and Well, Vol. 9, issue 2, 2003

News from Iowa’s Center for Agricultural Safety and Health (I-CASH)

Farm Families Alive and Well, Vol. 9, issue 3, 2003

News from Iowa’s Center for Agricultural Safety and Health (I-CASH)

Farm Families Alive and Well, Vol. 9, issue 4, 2003

News from Iowa’s Center for Agricultural Safety and Health (I-CASH)

Quick Reads, December 9, 2013

IDPH Quick Reads is an electronic newsletter produced by the Director’s Office at the Iowa Department of Public Health. IDPH Quick Reads are published every three to four weeks.

La nouvelle Justine, ou Les malheurs de la vertu. T. 9 / , suivie de L'histoire de Juliette, sa soeur. Ouvrage orné d'un frontispice et de cent sujets gravés avec soin... Tome premier [-dixième]

Comprend : L'Histoire de Juliette...

Induction of brain aquaporin 9 (AQP9) in catecholaminergic neurons in diabetic rats.

Aquaporin 9 facilitates the diffusion of water but also glycerol and monocarboxylates, known as brain energy substrates. AQP9 was recently observed in catecholaminergic neurons that are implicated in energy homeostasis and also possibly in neuroendocrine effects of diabetes. Recently it has been observed that the level of AQP9 expression in hepatocytes is sensitive to the blood concentration of insulin. Furthermore, insulin injection in the brain is known to be related to the energy homeostasis. Based on these observations, we investigated if the concentration of insulin affects the level of brain AQP9 expression and if so, in which cell types. This study has been carried out, in a model of the diabetic rat generated by streptozotocin injection and on brainstem slices. In diabetic rats showing a decrease in systemic insulin concentration, AQP9 is only increased in brain areas containing catecholaminergic neurons. In contrast, no significant change is detected in the cerebral cortex and the cerebellum. Using immunocytochemistry, we are able to show that the increase in AQP9 expression is specifically present in catecholaminergic neurons. In brainstem slice cultures, 2 microM insulin induces a significant decrease in AQP9 protein levels 6 h after application, suggesting that brain AQP9 is also regulated by the insulin. These results show that the level of expression of brain AQP9 is affected by variations of the concentration of insulin in a diabetic model and in vitro.

Iowa Lottery Action, Vol. 20, No. 1, Jan. 27-Feb. 9, 2014

Iowa Lottery Retailer Newsletter

Iowa Lottery Action, Vo. 20, No. 3 Feb. 24 - March 9, 2014

Iowa Lottery Retailer Newsletter